Immuno-inflammatory markers of syntropic cardiovascular diseases

Objective: To study the immuno-inflammatory markers of coronary heart disease, arterial hypertension and their combined course. The research work included 116 patients with cardiovascular disease of middle and old age. The average age of patients is 62.4±1.27. All patients were examined at the Bukhara branch of the Republican scientific and practical Center for emergency medical care. During the analysis, it was found that the level of systolic arterial blood pressure directly depends on the concentration of fibrinogen – r = 0.30 and oppositely depends on the concentration of procalcitonin (PCT) – r = -0.3 and IL-6 – r = -0.26. At the same time, a noticeable positive association of heart rate with creatinine in the blood – r = 0.35 was also revealed. The established connections show the contribution of inflammation syndrome (immune) in the progression of hypertension, or rather, indicators of the progression of hypertension in coronary heart disease are creatinine, fibrinogen, PCT and IL-6. Due to the high and noticeable correlation with the studied immuno-biochemical parameters of blood and functional parameters of the heart, IL-6 is a more informative indicator of the progression of coronary heart disease with the risk of complications and multiple organ failure. Thus, the established connections in our studies allow us to include the conclusion that, along with the above, risk factors for the development of rupture and/ or aneurysm of the aorta in CHD are an increase in the blood level of complement C3, IL-17 and PCT. Consequently, with an increase in the level of VEGF in the blood in CHD AS, the risk of an increase in the thickness of the LV in the diastole increases, and an increase in IL-6, IL-17A and urea in the blood shows a decrease in the thickness of the LV in the diastole, which makes it possible to differentiate the restrictive variant from the hypertrophic form in atypical angina. Due to the high and noticeable correlation with the studied immuno-biochemical parameters of blood and functional parameters of the heart, IL-6 is a more informative indicator of the progression of coronary artery disease with the risk of complications and multiple organ failure.

1. Akhmaltdinova L., Sirota V., Zhumaliyeva V., Babenko D., Kadyrova I., Tauesheva Z., Taizhanova D., Ibraeva A., Maratkyzy M., Turmukhambetova A. Inflammatory serum biomarkers in colorectal cancer in kazakhstan population. Int. J. Inflamm., 2020, Vol. 2020, 9476326. doi: 10.1155/2020/9476326.

2. Bashirov N.H. Markers of risk factors for the development of cardiovascular diseases. Eurasian Heart Journal, 2020, no. 3, pp. 78-84. (In Russ.)

3. Cypowyj S., Picard C., Maródi L., Casanova J.-L., Puel A. Immunity to infection in IL-17-deficient mice and humans. Eur. J. Immunol., 2012, Vol. 42, pp. 2246-2254.

4. DeBerge M.P., Ely K.H., Enelow R.I. Soluble, but not transmembrane, TNF-α is required during influenza Infection to Limit the Magnitude of immune Responses and the Extent of Immunopathology. J. Immunol., 2014, Vol. 92, no. 12, pp. 5839-5851.

5. Kuzuya M., Ramos M.A., Kanda S., Koike T., Asai T., Maeda K., Shitara K., Shibuya M., Iguchi A. VEGF protects against oxidized LDL toxicity to endothelial cells by an intracellular glutathione-dependent mechanism through the KDR receptor. Arterioscler. Thromb. Vasc. Biol., 2001, Vol. 21, pp. 765-770.

6. Szretter K.J., Gangappa S., Lu X., Smith C., Shieh W.-J., Zaki S.R., Sambhara S., Terrence M Tumpey, Jacqueline M Katz Role of Host Cytokine Responses in the Pathogenesis of avian H5N1 Influenza Viruses in Mice. J. Virol., 2007, Vol. 81, no. 6, pp. 2736-2744.

7. Tsutsumi Y., Losordo D.W. Double face of VEGF. Circulation, 2005, Vol. 112, pp. 1248-1250.

8. Zheng W., Seftor E.A., Meininger C.J., Hendrix M.J., Tomanek R.J. Mechanisms of coronary angiogenesis in response to stretch: role of VEGF and TGFβ. Am. J. Phisiol. Heart Circ. Phisiol., 2001, Vol. 280, pp. 909-917.