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Медицинская иммунология

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γδТ-ЛИМФОЦИТЫ: ОБЩАЯ ХАРАКТЕРИСТИКА, СУБПОПУЛЯЦИОННЫЙ СОСТАВ, БИОЛОГИЧЕСКАЯ РОЛЬ И ФУНКЦИОНАЛЬНЫЕ ОСОБЕННОСТИ

https://doi.org/10.15789/1563-0625-2009-2-3-115-130

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Аннотация

Резюме. γδТ-лимфоциты представляют собой малоизученную гетерогенную популяцию Т-лимфоцитов, доминирующую в слизистых оболочках и сочетающую в себе свойства как клеток врожденного, так и приобретенного иммунитета. Отсутствие процессинга и МНС-рестрикции обуславливает способность γδТ-клеток идентифицировать широкий спектр антигенов, природа которых, как и механизм распознавания, до конца не установлены. Многообразие биологических функций, основными из которых являются цитолиз, иммунорегуляция, презентация антигена и репарация поврежденных тканей, определяют уникальную роль данной популяции при инфекционных, опухолевых и аутоиммунных заболеваниях. В настоящий момент, основные уcилия исследователей направлены на изучение терапевтического потенциала γδТ-лимфоцитов, поиск и продукцию γδТ-клеточных агонистов, а также планирование и оптимизацию терапевтических протоколов, мишенью которых являются γδТ-лимфоциты.

Об авторах

Д. Б. Нижегородова
Белорусская медицинская академия последипломного образования, г. Минск
Россия

иммунологическая группа, Центральная научно-исследовательская лаборатория

220073, ул. Притыцкого, 18, корп. 3, кв. 35. Тел.: (+375-17) 265-33-56. Факс: (+375-17) 265-46-43


М. М. Зафранская
Белорусская медицинская академия последипломного образования, г. Минск
Россия

иммунологическая группа, Центральная научно-исследовательская лаборатория



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Для цитирования:


Нижегородова Д.Б., Зафранская М.М. γδТ-ЛИМФОЦИТЫ: ОБЩАЯ ХАРАКТЕРИСТИКА, СУБПОПУЛЯЦИОННЫЙ СОСТАВ, БИОЛОГИЧЕСКАЯ РОЛЬ И ФУНКЦИОНАЛЬНЫЕ ОСОБЕННОСТИ. Медицинская иммунология. 2009;11(2-3):115-130. https://doi.org/10.15789/1563-0625-2009-2-3-115-130

For citation:


Nizhegorodova D.B., Zafranskaya M.M. γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES. Medical Immunology (Russia). 2009;11(2-3):115-130. (In Russ.) https://doi.org/10.15789/1563-0625-2009-2-3-115-130

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