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A ROLE FOR CELLULAR IMMUNITY IN EARLY POSTPARTUM PERIOD

https://doi.org/10.15789/1563-0625-ARF-2275

Abstract

The functioning of the secretory organs is closely related to the activity of the immune system. As is well known, this participation is manifested in the fact that at certain stages of activity, the lymphoid cells migrating to the organ can be involved in the regulation of secretion. In addition, the products of the immune system and even its cellular elements can become components of a number of secrets. Colostrum and milk contain a large number of cells of a wide spectrum (up to 1/3 of the volume), of which the number of lymphocytes is up to 16% of leukocytes. Lymphocytes, in an immunologically active form, entering the newborn’s body with colostrum, activate the cellular immunity system. The transport of lymphokinin mediators plays a certain role in this process. Microphages, T- and B-lymphocytes, penetrating through the intercellular spaces into the lymphoid layer of the intestine, transmit immunoreceptors to the prolymphocytes of the newborn, "armed" with their activity to recognize genetically foreign ones. The lymphocytes contained in colostrum are the cells of the immune system that provide cellular and humoral immunity. They are mainly represented by T-cells, B-cells and killer cells. Milk T-cells produce a full spectrum of immune regulatory proteins such as interferon, tumor necrosis factor alpha. These cells are the cells of the immune memory. Newborns who received the first portion of colostrum no later than an hour after birth are characterized by an increased number of leukocytes, more pronounced phagocytosis, which indicates the stimulation of hemo- and lymphocytosis. When carrying out transmission and scanning electron microscopy in the epithelial layer of the intestine, cellular elements were found that got there from the intestinal lumen. Microsections show how cells of a lymphoid nature, pushing apart the structures of the epithelial layer, bypass natural barriers and, at the same time, retain their physiological usefulness. The possibility of penetration of immunocompetent cells of the mother’s colostrum into the bloodstream of the young is proved using the natural label of the female’s cells – sex chromatin. Naturally, sex chromatin-labeled cells were sought in male newborns. The detection of colostrum cells in the intestinal wall and bloodstream of the young is approximately 25% in the blood, 1% in the lymph, and about 70% in the intestine. There is no doubt that the leukocytes of colostrum are of exceptional importance in creating immunity in newborn animals. 

About the Authors

N. A. Panova
St. Petersburg State University of Veterinary Medicine
Russian Federation

PhD (Biology), Associate Professor, Department of Biochemistry and Physiology,

196084, St. Petersburg, Chernigovskaya str., 5



V. G. Skopichev
V. Almazov National Medical Research Centre
Russian Federation

PhD, MD (Biology), Professor, Department of Physiology, Faculty of Medicine, 

St. Petersburg



References

1. Dementyeva Yu.N. Immunological aspects of breastfeeding. Russian Bulletin of Perinatology and Pediatrics, 2015. Vol. 60, no. 4, pp. 19-24. (In Russ.)

2. Hurley W.L. Mammary gland growth in the lactating sow. Livestock Product. Sc., 2001, Vol. 70, no. 1/2, pp. 149-157.

3. Hurley W.L., Kim S.W. Characterization of mammary gland development in pregnant gilts. J. Anim. Sci., 2006, Vol. 84, no. 3, pp. 579-587.

4. Kolyakov Ya.E. Veterinary immunology. Moscow: Agropromizdat, 1986. 227 p. (In Russ.)

5. Markowska-Daniel I., Pomorska-Mól M. Shifts in immunoglobulins levels in the porcine mammary secretions during whole lactation. Bull. Vet. Inst. in Pulawy, 2010, Vol. 54, no. 3, pp. 345-349.

6. Markowska-Daniel I., Pomorska-Mól M., Pejsak Z. Dynamic changes of immunoglobulin concentrations in pig colostrum and serum around parturition. Pol. J. Vet. Sci., 2010, Vol. 13, no. 1, pp. 21-27.

7. Mielke H. Geschichtliches und Grundlagen der immunobiologisehen Bezichungen zwischen Muttertier und Frucht beim Rind. Mh. Vet. Med., 1979, Bd. 34, no. 6, pp. 217-223.

8. Panova N.A., Skopichev V.G., Polistovskaya P.A. Immune cell composition and cell-related structure in mouse mammary gland during lactation and physiological quiescence. Regulatory Issues in Veterinary Medicine, 2017, no. 3, pp. 193-196. (In Russ.)

9. Plyashchenko S.I., Sidorov V.T., Trofimov A.F. Breeding and farming healthy calves. Minsk: Uradzhay, 1990. 250 p. (In Russ.)

10. Pogodaeva P., Skopichev V., Alistratov F., Dushenina O., Vasilyeva S., Vasilyev R., Pilayeva N. Cells of immune memory in mice in the colostrums. Journal of the Reproduction in Domestic Animals, 2019, Vol. 54, no. 3, p. 103.

11. Skopichev V.G., Maksimyuk N.N. A milk: a study guide. St. Peterburg: Prospekt Nauki, 2011 368 p. (In Russ.)

12. Skopichev V.G., Prozorovskiy V.B. Mammary gland immunobiology and lactation performance. Beau Bassin: Lap LAMBERT Academic Publishing, 2018. 328 p. (In Russ.)


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For citations:


Panova N.A., Skopichev V.G. A ROLE FOR CELLULAR IMMUNITY IN EARLY POSTPARTUM PERIOD. Medical Immunology (Russia). 2021;23(4):853-858. https://doi.org/10.15789/1563-0625-ARF-2275

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ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)