IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS
https://doi.org/10.15789/1563-0625-2007-4-5-541-545
Abstract
Abstract. Sixty-nine children (5 to 14 years old) with infectious mononucleosis caused by EBV were observed in acute phase and during recovery period. The indexes under study did evaluate cell-mediated and humoral immunity, levels of spontaneous and mitogen-induced production of IL-2, IL-10, IFNγ by peripheral blood mononuclears. We have founded appropriate changes to be dependent on clinical phase of the disease. The most significant changes were revealed during acute phase of disease. A positive dynamics of cell-mediated and humoral immune response was observed during convalescence period. However, complete normalization of most immunologic indexes and cytokine status did not occur, corresponding to the clinical signs. This situation necessitates immune rehabilitation to be carried out for the children having at this phase of infectious mononucleosis.
About the Authors
L. M. Kurtasova
Красноярская государственная медицинская академия, г. Красноярск
Russian Federation
Russian Federation
A. E. Golovanova
Красноярская государственная медицинская академия, г. Красноярск
Russian Federation
Russian Federation
References
1. Иванова В.В., Железникова Г.Ф., Аксенов О.А., Букина А.А. Инфекционный мононуклеоз: клиника, патогенез, новое в диагностике и терапии // Инфекц. болезни. – 2004. – № 4. – С. 5-12.
2. Носик Н.Н. Цитокины при вирусных инфекциях // Вирусология. – 2000. – № 1. – С. 4-9.
3. Помогаева А.П., Уразова О.И., Потарская Е.В., Файт Е.А., Перевозчикова Т.В. К патогенезу инфекционного мононуклеоза // Инфекционные болезни. – 2005. – Т. 3, № 4. – С. 35-38.
4. Симбирцев А.С. Интерлейкин-2 и рецепторный комплекс интерлейкина-2 в регуляции иммунитета // Иммунология. – 1998. – № 8. – С. 3-8.
5. Ярилин А.А. Система цитокинов и принципы ее функционирования в норме и при патологии // Иммунология. – 1997. – № 3. – С. 7-12.
6. Boyum A. Isolation of lymphocytes from blood and bone marrow // Scand. J. Clin. Lab. Invest. – 1968. – Vol. 97, N 21. – P. 77-80.
7. Fickenscher H., Hur S., Kopers H., Knappe A., Wittmann S., Sticht H. The interleukin-10 family of cytokines // Trends Immunol. – 2002. – Vol. 23, N 2. – P. 89-95.
8. Haskova V., Kaslik J., Riha J, Rovensky J. Simple method of circulating immune complex detection in human sera by polyethylene glycol precipitation // J. Immunol. – 1978. – N 154. – P. 399-406.
9. Manchini G., Carbonaro A.O., Haremans J.F. Immunochemical quantitation of antigens by single radial diffusion // Immunochemistry. – 1965. – Vol. 2, N 1. – P. 235-255.
10. Ohga S., Nomura A., Takada H. Dominant expression of interleukin-10 and trasforming growth factor-beta genes in activated T-cells of chronic active Epstein–Barr virus infection // J. Med. Virol. – 2004. – Vol. 74, N 3. – Р. 449-458.
Review
For citations:
Kurtasova L.M., Golovanova A.E. IMMUNOLOGICAL INDEXES AND CYTOKINE PROFILE IN THE CHILDREN DURING INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS. Medical Immunology (Russia). 2007;9(4-5):541-545. (In Russ.) https://doi.org/10.15789/1563-0625-2007-4-5-541-545
Views:
1071
Email this article 