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Features of cytokine spectrum in chronic urticarial

https://doi.org/10.15789/1563-0625-FOC-2332

Abstract

Urticaria is a serious medical and social problem due to its high prevalence, lack of unified approaches to diagnosis and treatment, with high financial costs for therapy and rehabilitation. Long-term recurrent course of the disease, resistance to traditional methods of therapy lead to a significant decrease in the quality of life of patients with chronic urticaria. Itching accompanying this disease leads to deterioration in the patient’s general well-being, frequent sleep disturbances and, as a result, significant decrease in working capacity. Up to the present moment, etiopathogenesis of urticaria is a complex challenge due to the multivector nature of cytokine response, interference of protides of the complement system, patterns of kininbradykinin interference, peculiar expression of the immune response. The problem of current population is lipotrophy – chronic, heterogeneous, cytokine mediating, progressive inflammatory disease attributed by abnormal accumulation of excessive adipose tissue. Adipose tissue, being a sporadic organ of endocrine system secretes multiple hormone-like substances, mediators, cytokines and chemokines which have been given a common name, i.e., adipokines or adipocytokines. True signs of destructive parenchymal changes of liver in the form of increasing bilirubin and AST, decreasing level of vitamin D in patients with chronic recurrent urticarial in presence of obesity have been revealed during the study performed. The action of cytokines, as mediators of intercellular interaction is closely related to the physiological and pathophysiological responses of the body with modulation of both local and systemic defense mechanisms. It is assumed that the cytokine status of patients with chronic urticaria is dominated by cytokines that increase allergic inflammation of the skin. Analysis of 12 T regulatory biomarker concentrations revealed increased concentrations of IL-10, IL-19, IL-20, IL-27, IL-35, IFNλ2 and IFNλ1 in blood serum of patients with chronic urticaria. It was found that in the group of patients with chronic urticaria and increased body mass index (BMI), the level of all investigated T regulatory cytokines is lower than in the patients with normal BMI, except for IL-10. Decreased levels of biologically active IFN I (α/β) and, especially, IFN II (γ) types of blood leukocytes in patients with chronic urticaria were revealed. The levels of 12 Treg cytokines were determined in blood serum of patients with chronic urticaria, showing trend for imbalance of Treg cytokines: IL-10, IL-19, IL-20, IL-27, IL-35, IFNλ2 and IFNλ1.

About the Authors

Т. P. Оspelnikova
I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation

Ospelnikova Tatiana Р. - PhD (Medicine), Head, Laboratory of Interferons, I. Mechnikov Research Institute of Vaccines and Sera, Moscow, RF.

105064, Moscow, Malyy Kazennyy lane, 5а. Phone: 7 (903) 521-32-60


Competing Interests:

no



A. A. Denisov
Siberian State Medical University
Russian Federation

Denisov Andrey A. - PhD, MD (Medicine), Professor, Department of Allergology and Immunology, Siberian SMU.

Tomsk


Competing Interests:

no



N. A. Cherevko
Siberian State Medical University; Center of Family Medicine
Russian Federation

Cherevko Natalia A. - PhD, MD (Medicine), Professor, Department of Allergology and Immunology.

Tomsk


Competing Interests:

no



V. V. Кuzmina
I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation

Kuzmina Valeria V. - Junior Research Associate, Laboratory of Interferons.

Moscow


Competing Interests:

no



V. S. Dmitruk
Siberian State Medical University
Russian Federation

Dmitruk Vadim S. - PhD, MD (Medicine), Professor, Department of Dermatovenereology and Cosmetology.

Tomsk


Competing Interests:

no



D. S. Nagaitseva
Center of Family Medicine
Russian Federation

Nagaitseva Daria S. - Laboratory Assistant.

Tomsk


Competing Interests:

no



I. S. Каrgov
Bio-Rad Laboratories
Russian Federation

Kargov Ivan S. - PhD (Chemistry), Proteomics Product Production Specialist in Proteomics, Life Science Group.

Moscow


Competing Interests:

no



References

1. Golubchikova R.N., Danilycheva I.V., Rebrova O.Yu. Retrospective analysis of anamnestic and clinical and laboratory data in patients with chronic idiopathic urticaria. Rossiyskiy allergologicheskiy zhurnal = Russian Allergology Journal, 2011, no. 4, pp. 23-33. (In Russ.)

2. Dutova S.V., Saranchina Yu.V., Kilina O.Yu., Khanarin N.V., Kulakova T.S., Evelson Yu.A. Interleukin 19: role in atherogenesis and inflammatory processes, prospects for use (literature review). Vestnik novyh medicisnkih tekhnologij = Journal of New Medical Technologies, 2019, Vol. 26, no. 3, pp. 68-74. (In Russ.)

3. Ershov F.I., Ospelnikova T.P. A modern arsenal of antiherpetic drugs. Infektsii i antimikrobnaya terapiya = Infections and Antimicrobial Therapy, 2001, Vol. 3, no. 4, pp. 100-104. (In Russ.)

4. Ospelnikova T.P., Kolodyazhnaya L.V., Tabakov V.Yu., Ershov F.I. Method for determining the production of interferons as parameters of innate immunity. Patent for invention of the Russian Federation No. 2657808 dated 07/10/2017, published: 06/15/2018.

5. Bracken S.J., Abraham S., MacLeod A.S. Autoimmune theories of chronic spontaneous urticaria. Front. Immunol., 2019, Vol. 10, 627. doi: 10.3389/fimmu.2019.00627.

6. Esser N., Legrand-Poels S., Piette J., Scheen A.J., Paquot N. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res. Clin. Pract., 2014, Vol. 105, no. 2, pp. 141-150.

7. Feng H., Feng J., Zhang Z., Xu Q., Hu M., Wu Y., Lu Y. Role of IL-9 and IL-10 in the pathogenesis of chronic spontaneous urticaria through the JAK/STAT signalling pathway. Cell Biochem. Funct., 2020, Vol. 38, no. 4, pp. 480-489.

8. Folci M., Heffler E., Canonica G.W., Furlan R., Brunetta E. Cutting edge: biomarkers for chronic spontaneous urticaria. J. Immunol. Res., Vol. 2018, 5615109. doi: 10.1155/2018/5615109.

9. Haynes B., Soderberg K.A., Fauchi A.S. The immune system in health and disease. Harrison’s principles of internal medicine. In: Jameson J., Fauci A.S., Kasper D.L., Hauser S.L., Longo D.L., Loscalzo J. eds. Harrison’s Principles of Internal Medicine. 19th ed. McGraw Hill Education, 2015.

10. Hillyer P., Mane V.P., Schramm L.M., Puig M., Verthelyi D., Chen A., Zhao Z., Navarro M.B., Kirschman K.D., Bykadi S., Jubin R.G., Rabin R.L. Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent. Immunol. Cell Biol., 2012, Vol. 90, no. 8, pp. 774-783.

11. Liu Y., Xu D., Yin C., Wang S., Wang M., Xiao Y. IL-10/STAT3 is reduced in childhood obesity with hypertriglyceridemia and is related to triglyceride level in diet-induced obese rats. BMC Endocr. Disord., 2018, Vol. 18, no. 1, 39. doi: 10.1186/s12902-018-0265-z.

12. Mathian A., Mouries-Martin S., Dorgham K., Devilliers H., Yssel H., Garrido Castillo L., Cohen-Aubart F., Haroche J., Hié M., Pineton de Chambrun M., Miyara M., Pha M., Rozenberg F., Gorochov G., Amoura Z. Ultrasensitive serum interferon-α quantification during SLE remission identifies patients at risk for relapse. Ann. Rheum. Dis., 2019, Vol. 78, no. 12, pp. 1669-1676.

13. Wang T., He C. Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine Growth Factor Rev., 2018, Vol. 44, pp. 38-50.


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For citations:


Оspelnikova Т.P., Denisov A.A., Cherevko N.A., Кuzmina V.V., Dmitruk V.S., Nagaitseva D.S., Каrgov I.S. Features of cytokine spectrum in chronic urticarial. Medical Immunology (Russia). 2021;23(6):1347-1356. (In Russ.) https://doi.org/10.15789/1563-0625-FOC-2332

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ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)