ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
https://doi.org/10.15789/1563-0625-2014-1-53-60
Abstract
We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,
upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, as
well as the production of relevant cytokines by the cells of patients with multiple sclerosis (MS), as compared
with healthy donors. It was found that the levels of CD4+FoxP3+CTLA-4+ (Treg) lymphocytes in MS patients
were initially lower than those of healthy donors. Percentages of CD4+RORγt+IL-17A+ (Th17) lymphocytes
did not significantly differ from those in healthy donors, still showing a tendency for increase. Baseline levels
of IL-17 and IL-6 in cell culture supernates of MS patients were higher than in healthy donors, along with
reduced contents of the anti-inflammatory IL-10 cytokine. Percentage of Tregs was increased under the
influence of estriol, whereas Th17 proportion was diminished. These hormonal effects upon lymphocytes
were reproducible both for healthy donors, and MS patients. Moreover, estriol stimulated IL-10 production
and inhibited secretion of IL-6 and IL-17. Therefore, a sufficient release of MS symptoms observed during
pregnancy may be explained by influence of estriol, thus extending opportunities for rational use of this steroid
hormone in MS treatment
About the Authors
I. V. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm
Russian Federation
Russian Federation
PhD (Biology), Research Associate, Laboratory of Immune Regulation
S. V. Shirshev
Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Head, Laboratory of Immune Regulation
I. Yu. Danchenko
Perm State Medical Academy, Perm
Russian Federation
Russian Federation
Postgraduate Student, Perm State Medical Academy
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Review
For citations:
Nekrasova I.V., Shirshev S.V., Danchenko I.Yu. ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS. Medical Immunology (Russia). 2014;16(1):53-60. (In Russ.) https://doi.org/10.15789/1563-0625-2014-1-53-60
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