Recent achievements in CAR-T cell immunotherapy for glioblastoma treatment
https://doi.org/10.15789/1563-0625-RAI-2111
Abstract
Glioblastoma remains the most common and aggressive primary brain tumor today. Because of the neuroanatomical location of glioblastoma, conventional chemotherapy and radiation therapy have limited efficacy in patients with these tumors. Over the past decade, antitumor immunotherapy has become widespread among modern therapeutic approaches. The importance of immunotherapeutic methods lies in their ability to increase the effectiveness of cancer treatment and prevent relapses by enhancing the systemic and local immune response against tumor cells.
One of the most promising directions in modern immunotherapy is CAR-T therapy, or adoptive cell therapy using genetically modified T-lymphocytes. The functional advantage of CAR-T therapy is its ability to genetically modify lymphocytes, leading to their activation in vitro.
This review examines the key principles of CAR-T therapy and analyzes the published results of clinical trials for the treatment of glioblastoma using several modifications of CAR-T cells.
About the Authors
S. V. Timofeeva
National Medical Research Centre for Oncology
Russian Federation
Competing Interests:
Russian Federation
Research Associate, Cell Technology Laboratory.
344037, Rostov-on-Don, 14th Line, 63. Phone: 7(863) 300-02-00 (acc. 473)
Competing Interests:
not
A. O. Sitkovskaya
National Medical Research Centre for Oncology
Russian Federation
Competing Interests:
Russian Federation
Head, Cell Technology Laboratory.
Rostov-on-Don
Competing Interests:
not
I. A. Novikova
National Medical Research Centre for Oncology
Russian Federation
Competing Interests:
Russian Federation
PhD (Medicine), Deputy General Director for Research.
Rostov-on-Don
Competing Interests:
not
M. A. Ezhova
National Medical Research Centre for Oncology
Russian Federation
Competing Interests:
Russian Federation
Clinical Oncologist.
Rostov-on-Don
Competing Interests:
not
E. P. Lysenko
National Medical Research Centre for Oncology
Russian Federation
Competing Interests:
Russian Federation
PhD (Medicine), Clinical Oncologist.
Rostov-on-Don
Competing Interests:
not
O. I. Kit
National Medical Research Centre for Oncology
Russian Federation
Competing Interests:
Russian Federation
PhD, MD (Medicine), Professor, Corresponding Member, Russian Academy of Sciences, General Director.
Rostov-on-Don
Competing Interests:
not
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Timofeeva S.V., Sitkovskaya A.O., Novikova I.A., Ezhova M.A., Lysenko E.P., Kit O.I. Recent achievements in CAR-T cell immunotherapy for glioblastoma treatment. Medical Immunology (Russia). 2021;23(3):483-496. (In Russ.) https://doi.org/10.15789/1563-0625-RAI-2111
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