Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus
https://doi.org/10.15789/1563-0625-EOB-2091
Abstract
Background: Hepatitis B is the main infection of the injured liver for humans. Inflammation of the liver is caused by hepatitis viruses may lead to cirrhosis and hepatocellular carcinoma. The B-cell stimulatory factor 2 (BSF-2) is one of the cytokines that affect the regulation and differentiation of the human immune response. Objective: this report aims to estimate the BSF-2, GPT, and GOT levels in patients’ serum with different stages of hepatitis B compared with healthy control. Methods: This study assessed 52 patients presumably with acute and chronic cases who have HBsAg positive. BSF-2 was detected using ELISA assay. Biochemical parameters were determined using kits of an automated analyzer. SPSS version-16 software was used for statistical analysis. Results: Acute hepatitis B patients had shown elevation in BSF-2 level more than of chronic hepatitis B. GPT and GOT levels elevated in the acute hepatitis group more than of the chronic hepatitis group. We reported a significant value between BSF-2, GOT, and GPT levels. We didn’t score an association between patient’s age and cases groups of hepatitis. Conclusion: our data confirmed increasing of BSF-2 levels with the increase of GOT level more than GPT level with acute hepatitis B. BSF-2, GPT and GOT levels are varied in different courses of acute and chronic HBV. We surmised that the elevation of BSF-2 levels designates liver injury of patients with acute HBV.
Supporting agencies: Lastly, we send thanks to the blood bank center and Ibn-Alatheer teaching hospital for providing serum samples. We also send thankful to the University of Mosul.
About the Authors
Ali A. Dawood
College of Medicine, University of Mosul
Iraq
Iraq
Ph.D. Microbiology, Lecturer, Department of Anatomy
Al-Jameaa, st.1, Mosul
Mahmood A. A. Altobje
College of Medicine, University of Mosul
Iraq
Iraq
Ph.D. Immunology, Associate Professor, Department of Biology
Al-Jameaa, st.1, Mosul
Zeyad T. Alrassam
College of Medicine, University of Mosul
Iraq
Iraq
Ph.D. Microbiology, Lecturer, Department of Biophysics
Al-Jameaa, st.1, Mosul
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For citations:
Dawood A.A., Altobje M.A., Alrassam Z.T. Elevation of BSF-2 Level in Serum of Patients with Hepatitis B Virus. Medical Immunology (Russia). 2021;23(1):87-94. https://doi.org/10.15789/1563-0625-EOB-2091
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