INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA
https://doi.org/10.15789/1563-0625-2014-1-27-34
Abstract
Incidence of different types of dislipoproteinemias (DLPs) and a balance between apoptosis and
proliferation of lymphocytes were studied in males exhibiting initial manifestations of cerebral blood flow
insufficiency (ICBI). In general, high intensity of lymphocyte activation was revealed in patients with ICBI,
with amplified proliferative potential demonstrable in this group. We have also shown a trend to increased
numbers of T and B lymphocytes expressing antiapoptogenic bcl-2 protein. The changes in apoptosis and cell
proliferation intensity were more pronounced in IIA and IIB types of DLP. In these groups, unidirectional
changes of FasR expression were observed. However, the parameters reflecting readiness to apoptosis were
changed multidirectionally. Cholesterol and oxysterols transported to the cells under excessive dyslipidemia
may influence activities of transcription factor genes (bcl-2, Fas-regulatory gene (TDAG51), thus, probably,
causing an imbalance between cellular proliferation and apoptosis.
About the Authors
A. V. Zurochka
Research Institute of Immunology and Physiology, Russian Academy of Sciences, Ural Branch, Ekaterinburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor,
Research Institute of Immunology and Physiology,
Russian Academy of Sciences, Ural Branch
E. V. Davydova
South Ural State Medical University, Chelyabinsk
Russian Federation
Russian Federation
PhD (Medicine), Senior Lecturer,
Department of Pathophysiology, South Ural State
Medical University, Chelyabinsk
D. A. Altman
South Ural State Medical University, Chelyabinsk
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
PhD, MD (Medicine), Professor,
Department of Neurology, South Ural State Medical
University, Chelyabinsk
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Review
For citations:
Zurochka A.V., Davydova E.V., Altman D.A. INTENSITY OF APOPTOTIC AND PROLIFERATIVE EVENTS IN LYMPHOCYTES UNDER DYSLIPIDEMIC CONDITIONS AT EARLY STAGES OF CHRONIC BRAIN ISCHEMIA. Medical Immunology (Russia). 2014;16(1):27-34. (In Russ.) https://doi.org/10.15789/1563-0625-2014-1-27-34
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