FEATURES OF LOCAL AND SYSTEMIC IMMUNITY, AND MORPHO-FUNCTIONAL STATE OF ENDOMETRIUM IN WOMEN WITH ANOVULATORY SYNDROME
https://doi.org/10.15789/1563-0625-2008-4-5-353-360
Abstract
Abstract. Persisting acyclic hypoestrogenemia and progesterone insufficiency in the women with anovulatory syndrome and altered reproductive functions are associated with disturbed endometrial morphology, increased expression of receptors for estrogenes, progesterone, redistribution of NK cells with predominance of CD16+NK cells in endometrium. Meanwhile, decreased number of CD16+ NK cells and cytotoxic CD8+ T cells in blood was accompanied by increased serum IFNγ levels, and enhanced spontaneous production of TNFα. (Med. Immunol., vol. 10, N 4-5, pp 353-360).
About the Authors
E. A. Michnina
Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-Петербург
Russian Federation
Russian Federation
E. K. Komarov
Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-Петербург
Russian Federation
Russian Federation
N. I. Davydova
Всероссийский Центр экстренной и радиационной медицины МЧС России им. А.С. Никифорова, Санкт-Петербург
Russian Federation
Russian Federation
V. N. Ellinidy
Всероссийский Центр экстренной и радиационной медицины МЧС России им. А.С. Никифорова, Санкт-Петербург
Russian Federation
Russian Federation
N. M. Kalinina
Всероссийский Центр экстренной и радиационной медицины МЧС России им. А.С. Никифорова, Санкт-Петербург
Russian Federation
Russian Federation
O. A. Dobrotvorceva
Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-Петербург
Russian Federation
Russian Federation
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Review
For citations:
Michnina E.A., Komarov E.K., Davydova N.I., Ellinidy V.N., Kalinina N.M., Dobrotvorceva O.A. FEATURES OF LOCAL AND SYSTEMIC IMMUNITY, AND MORPHO-FUNCTIONAL STATE OF ENDOMETRIUM IN WOMEN WITH ANOVULATORY SYNDROME. Medical Immunology (Russia). 2008;10(4-5):353-360. (In Russ.) https://doi.org/10.15789/1563-0625-2008-4-5-353-360
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