RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY
https://doi.org/10.15789/1563-0625-2019-4-661-668
Abstract
Intensivity of lymphocyte proliferative activity is an important and almost the only indicator of the level of functional activity of these cells, and the immune system in general. The aim of this study was to develop an adequate physiological test to determine the degree of functional activity of lymphoid cells. The choice of IL-1 as an activator of proliferation is justified by the presence of receptors to IL-1 on lymphoid cell membranes, the key role of this cytokine in the initiation of a wide range of biological effects of the immune system to antigen, including participation in intercellular cooperation and distant action on various cells. It was found that the ligand-receptor interaction of IL-1 by type I receptor activates neutral sphingomyelinase, and the sphingomyelin pathway of signal transduction in lymphocytes. The degree of activation of this enzyme depends on the type of stress and correlates with changes of the vector of humoral immune response and proliferative activity of lymphocytes. The level of IL-1 increases, but the activity of neutral sphingomyelinase and lymphoid cell proliferation is significantly reduced after applications of immunosuppressive stress in mice and rats. The change of the degree of lymphocyte proliferation has become a marker of the severity of the pathological process in clinic. A high degree of correlation between the low intensity of peripheral blood lymphocyte proliferation in response to IL-1 action and the unfavorable disease outcome in patients with severe combined trauma and children with purulent meningitis was established. Thus, the degree of lymphocyte proliferation in response to the action of the regulatory signal of IL-1 can be used both for the analysis of the effectiveness of immunomodulators, and as diagnostic and prognostic indicator in clinical practice.
About the Authors
S. N. Shanin
Institute of Experimental Medicine
Russian Federation
Russian Federation
РhD (Medicine), Senior Research Associate, Department of General Pathology and Pathophysiology
197376, Russian Federation, St. Petersburg, Acad. Pavlov str., 9a
Phone: 7 (812) 234-15-83
Fax: 7 (812) 234-94-93
E. A. Korneva
Institute of Experimental Medicine
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Full Member, Russian Academy of Sciences, Chief Research Associate, Department of General Pathology and Pathophysiology
197376, Russian Federation, St. Petersburg, Acad. Pavlov str., 9a
References
1. Boterashvili N.M., Rybakina E.G., Shanin S.N., Kozinets I.A., Sorokina M.N., Ivanova V.V. Interleukin 1 production and action in infants with serous and purulent meningitis. Meditsinskaya immunologiya = Medical Immunology (Russia), 2000, Vol. 2, no. 3, pp. 321-328. (In Russ.)
2. Korneva E.A., Shanin S.N., Rybakina E.G. Interleukin-1 in realisation of stress-induced changes in functions of the immune system. Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova = Sechenov Russian Journal of Physiology, 2000, Vol. 86, no. 3, pp. 292-302. (In Russ.)
3. Korneva E.A. Neuroimmunophysiology yesterday and present days. Klinicheskaya patofiziologiya = Clinical Pathophysiology, 2016, Vol. 22, no. 1, pp. 7-19. (In Russ.)
4. Levin S.G., Godukhin O.V. Modulating effect of cytokines on mechanisms of synaptic plasticity in the brain. Biokhimiya = Biochemistry, 2017, Vol. 82, no. 3, pp. 397-409. (In Russ.)
5. Simbirtsev A.S. Interleukin 1. Physiology. Pathology. Clinic. St. Petersburg: Foliant, 2011. 480 p.
6. Simbirtsev A.S. Cytokines in the pathogenesis and treatment of human diseases. St. Petersburg: Foliant, 2018. 512 p.
7. Traumatic disease and its complications / ed. Seleznev S.A., Bagnenko S.F., Shapot Yu.B., Kurygin A.A. St. Petersburg: Polytechnica, 2004. 414 p.
8. Besedovsky H.O., Del Rey A., Sorkin E., Dinarello C.A. Immunoregulatory feedback between Interleukin 1 and glucocorticoid hormones. Science, 1986, Vol. 223, no. 4764, pp. 652-654.
9. Black P.H. Stress and the inflammatory response: a review of neurogenic inflammation. Brain Behav. Immun., 2002, Vol. 16, no. 6, pp. 622-653.
10. Capuron L., Miller A.H. Immune system to brain signaling: neuro-psychopharmacological implications. Pharmacol. Therapeut, 2011, Vol. 130, no. 2, pp. 226-238.
11. Del Rey A., Verdenhalven M., Lörwald A.C., Meyer C., Hernangómez M., Randolf A., Brain-borne IL-1 adjusts glucoregulation and provides fuel support to astrocytes and neurons in an autocrine/paracrine manner. Mol. Psychiatry, 2016, Vol. 21, pp. 1309-1320.
12. Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol., 2009, Vol. 27, pp. 519-550.
13. Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood, 2011, Vol. 117, no. 14, pp. 3720-3732.
14. Dinarello C.A. Overview of the interleukin-1 family of ligands and receptors. Semin. Immunol., 2013, Vol. 25, no. 6, pp. 389-393.
15. Dunn A.J. Cytokine activation of the HPA axis. Ann. N.Y. Acad. Sci., 2000, Vol. 917, no. 1, pp. 608-617.
16. Gentile A., Fresegna D., Musella A., Sepman H., Bullitta S., de Vito F., Fantozzi R., Usiello A., Maccarrone M., Mercuri N.B., Lutz B., Mandolesi G., Centonze D. Interaction between interleukin-1beta and type-1 cannabinoid receptor isinvolved in anxiety-like behavior in experimental autoimmune encephalomyelitis. J. Neuroinflammation, 2016, Vol. 13, no. 1, pp. 231-244.
17. Greenfeder S.A., Nunes P., Kwee L., Labow M., Chizzonite R.A., Ju G. Molecular cloning and characterisation of a second subunit of the Interleukin 1 receptor complex. J. Biol. Chem., 1995, Vol. 270, pp. 13757-13785.
18. Guo H., Callaway J.B., Ting J.P. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med., 2015. Vol. 21, no. 7, pp 677-687.
19. Hewett S.J., Jackman N.A., Claycomb R.J. Interleukin-1beta in central nervous system injury and repair. Eur. J. Neurodegener. Dis., 2012, Vol. 1, no. 2, pp. 195-211.
20. Oleszycka E., Moran H.B., Tynan G.A., Hearnden C.H., Coutts G., Campbell M., Allan S.M., Scott C.J., Lavelle E.C. IL-1alpha and inflammasome-independent IL-1βeta promote neutrophil infiltration following alum vaccination. FEBS J., 2016, 283, pp. 9-24.
21. Palomo J., Dietrich D., Martin P., Palmer G., Gabay C. The interleukin (IL)-1 cytokine family – balance between agonists and antagonists in inflammatory diseases. Cytokine, 2015, Vol. 76, no. 1, pp. 25-37.
22. Rosenwasser L.J., Dinarello C.A. Ability of human leukocytic pyrogen to enhance phytohemagglutinin induced murine thymocyte proliferation. Cell Immunol., 1981, Vol. 63, no. 1, pp. 134-142.
23. Rybakina E.G., Shanin S.N., Korneva E.A. Cellular, molecular and signaling mechanisms in neuro-immune interactions under stress. Adv. Neuroimmune Biol., 2012, Vol. 3, no. 3-4, pp. 235-241.
24. So A., Dumusc A., Nasi S. The role of IL-1 in gout: from bench to bedside. Rheumatology (Oxford), 2018, Vol. 57, Suppl. 1, pp. i12-i19.
25. Tan Q., Hu J., Yu X., Guan W., Lu H., Yu Y., Yu Y., Zang G., Tang Z. The role of IL-1 family members and Kupffer cells in liver regeneration. BioMed Res. Int., 2016, Vol. 2016, 6495793, 6 p. doi: 10.1155/2016/6495793.
26. Wang X., Fu S., Wang Y., Yu P., Hu J., Gu W., Xu X.M., Lu P. Interleukin-1beta mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway. Mol. Cell. Neurosci., 2007, Vol. 36, no. 3, pp. 343-354.
Review
For citations:
Shanin S.N., Korneva E.A. RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY. Medical Immunology (Russia). 2019;21(4):661-668. (In Russ.) https://doi.org/10.15789/1563-0625-2019-4-661-668
Views:
784
Email this article 