ROLE OF PERIVASCULAR ADIPOSE TISSUE IN THE DEVELOPMENT OF ATHEROSCLEROTIC AND NONATHEROSCLEROTIC DISEASES
https://doi.org/10.15789/1563-0625-2019-4-633-642
Abstract
Perivascular adipose tissue surrounds most large blood vessels and plays an important role in vascular homeostasis. Recent studies have shown that perivascular adipose tissue effects vasodilation and vasoconstriction, which indicates that the perivascular adipose tissue regulates tone and diameter of the vessels. Adipocytokines and chemokines, secreted from the perivascular adipose tissue, apparently have direct access to the adjacent arterial wall by diffusion, or through vasa vasorum. The present data indicate that perivascular adipose tissue plays an important role in atherosclerosis, hypertension. Recently, some studies were performed that examined the role of perivascular adipose tissue in non-atherosclerotic vascular diseases, such as neointimal formation, aortic aneurysm, arterial stiffness and vasculitis. The present review will discuss a role of perivascular adipose tissue in pathogenesis of atherosclerosis, hypertension and non-atherosclerotic vascular diseases.
About the Authors
E. G. Uchasova
Federal State Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
PhD (Medicine), Senior Research Associate, Laboratory of Homeostasis Research
650002, Russian Federation, Kemerovo, Sosnovy bvld, 6
Phone: 7 (3842) 64-05-53
O V Gruzdeva
Federal State Research Institute for Complex Issues of Cardiovascular Diseases;
Kemerovo State Medical University
PhD, MD (Medicine), Head, Laboratory of Homeostasis Research; Associate Professor, Department of Pathological Physiology
650002, Russian Federation, Kemerovo, Sosnovy bvld, 6
Yu A Dyleva
Federal State Research Institute for Complex Issues of Cardiovascular Diseases
PhD (Medicine), |Senior Research Associate, Laboratory of Homeostasis Research
650002, Russian Federation, Kemerovo, Sosnovy bvld, 6
E V Belik
Federal State Research Institute for Complex Issues of Cardiovascular Diseases
Junior Research Associate, Laboratory of Homeostasis Research
650002, Russian Federation, Kemerovo, Sosnovy bvld, 6
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For citations:
Uchasova E.G., Gruzdeva O.V., Dyleva Yu.A., Belik E.V. ROLE OF PERIVASCULAR ADIPOSE TISSUE IN THE DEVELOPMENT OF ATHEROSCLEROTIC AND NONATHEROSCLEROTIC DISEASES. Medical Immunology (Russia). 2019;21(4):633-642. (In Russ.) https://doi.org/10.15789/1563-0625-2019-4-633-642
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