REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS
https://doi.org/10.15789/1563-0625-2018-4-589-596
Abstract
The paper presents evidence that the individuals with different blood groups and glucose levels exhibit individual IgE reagin responses to insulin. Thus, the persons with 0 (I) blood group showed the highest values of anti-insulin-specific IgE (124.83±67.9 kE/L) when their glucose level was under 4 mmol/l. Such values are characteristic to the patients with A (II) and B (III) blood groups with normal glucose levels. Among subjects with B (III) blood group showing decreased glucose values (< 4 mmol/L), the lowest insulin induction (0.85±0.05 mkE/ml) was observed, and the IgE production to insulin increased 80-fold, reaching 113.0±56.0 kE/L. At the first ("borderline") stage of carbohydrate metabolism disorders (glucose levels 6.0 to 7.6 mmol/L), the insulin production is increased 3-fold in 0 (I) and A (II) blood groups, whereas insulin levels in persons with B(III) blood group are near-normal (12.3±3.7), and IgE antibodies to insulin show lowest levels (27.2±9.08 kE/L), thus being 5 times lower when compared to the persons with B (III) blood group. However, carriers of all three group antigens and patients with expressed type 2 diabetes respond to increased glucose and insulin levels in blood by decreased production of specific IgE antibodies to insulin.
About the Authors
N. R. Telesmanich
Rostov State Medical University
Russian Federation
Russian Federation
PhD, MD (Biology), Professor, Department of General and Clinical Biochemistry No. 1,
Rostov-on-Don
M. A. Konovalchik
Rostov State Medical University
Russian Federation
Russian Federation
Graduate Student, Department of General and Clinical Biochemistry No. 1,
344010, Rostov-on-Don, Petrenko str., 6, apt 184
Z. I. Mikashinovich
Rostov State Medical University
Russian Federation
Russian Federation
PhD, MD (Biology), Professor, Head, Department of General and Clinical Biochemistry No. 1,
Rostov-on-Don
E. G. Krivolapova
Rostov State Medical University
Russian Federation
Russian Federation
Clinical Resident, Department of Neurology,
Rostov-on-Don
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For citations:
Telesmanich N.R., Konovalchik M.A., Mikashinovich Z.I., Krivolapova E.G. REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS. Medical Immunology (Russia). 2018;20(4):589-596. (In Russ.) https://doi.org/10.15789/1563-0625-2018-4-589-596
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