CHARACTERISTIC INFLUENCE OF PULSE ELECTROTHERAPY (ELECTRICAL SLEEP) AT A NEUROPEPTIDE-CYTOKINE LINKS IN ARTERIAL HYPERTENSION ACCOMPANIED BY A ASTHENONEUROTIC DISTURBANCES IN YOUNG MEN EMPLOYED IN STRESSFUL PROFESSIONS

Disorders in functioning of major regulatory systems in patients with somatic diseases required development of new and effective integrated approaches to their treatment and prevention. Effective electrotherapy (electrical sleep) is among these methods. Despite existence of studies proving high efficiency of electrical sleep results in therapeutic practice, some open questions remain concerning impact of this treatment upon neuropeptide-cytokine links of immune system, which is one of the most important effector of pathogenesis in cardiovascular diseases in young persons with hypertension from the group occupied with stressful jobs. In this connection, the aim of our study was to investigate the influence on electrical sleep upon neuropeptide-cytokine profile in arterial hypertension conditions accomplished by asthenic-neurotic disorders in young men from the group of stressful activities. The following treatment groups were formed: 1st (n = 12), antihypertensive therapy; 2nd (n = 10), complex therapeutic measures added to antihypertensive therapy plus minor tranquilizers; in the 3rd group (n = 12), electric sleep was performed. Neuropeptide-cytokine profile was investigated as serum contents of β-endorphin, proinflammatory (TNFα, IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines. In the course of the clinical and laboratory examination, the authors have found that electric sleep applied in a complex primary schedule, with antihypertensive drug treatment in patients with hypertension and asthenic-neurotic disorders proved to exert optimizing effect upon functioning of neuropeptide-cytokine pool of immune system, which manifested by stimulation of beta-endorphin production, a decrease via regulation of proinflammatory effectors (TNFα, IL-1β, IL-6), and increased anti-inflammatory cytokines (IL-4, IL-10).

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