STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE
https://doi.org/10.15789/1563-0625-2017-5-629-634
Abstract
We have investigated in vivo effects of quercetin dihydrate (QD) upon course of respiratory allergy produced in experimental murine model. To provoke allergy, serum ovalbumin (OVA) was injected at different terms. Following administration of QD at the stage of OVA sensitization, the balance of T-helper cytokines was changed (IL-2 was decreased along with increased IFNγ) accompanied by decreased allergen-specific IgG1, IgE and increased IgG2a in blood serum. At the stage of boosting the respiratory allergy, intravenous administration of QD caused reduction of inflammatory lung infiltration, and composition of bronchoalveolar lavage fluid was altered, i.e., IgG1 and IgE showed a decrease, along with higher IgG2a levels.
About the Authors
A. O. Kenkishvili
Russian National N.I. Pirogov Research Medical University.
Russian Federation
Russian Federation
Kenkishvili A.O., Postgraduate Student, Department of Pharmacology, Russian National N.I. Pirogov Research Medical University.
Moscow.
D. Z. Albegova
Russian National N.I. Pirogov Research Medical University.
Russian Federation
Russian Federation
Albegova D.Z., PhD (Medicine), Associate Professor, Department of Pharmacology, Russian National N.I. Pirogov Research Medical University.
Moscow.
O. S. Laptev
Federal D. Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology, and Immunology; Russian National N.I. Pirogov Research Medical University.
Russian Federation
Russian Federation
Laptev O.S., Postgraduate Student, Laboratory of Experimental and Clinical Pharmacology, Federal D. Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology, and Immunology; Assistant Professor, Department of Pharmacy, Russian National N.I. Pirogov Research Medical University.
117997, Russian Federation, Moscow, Ostrovityanova str., 1.
S. I. Pavlova
Federal D. Rogachev Research and Clinical Center for Pediatric Hematology, Oncology and Immunology; Chuvash State I.N. Ulianov University.
Russian Federation
Russian Federation
Pavlova S.I., PhD, MD (Medicine), Professor, Head, Department of Pharmacology, Clinical Phermacology and Biochemistry, Chuvash State I.N. Ulianov University, Cheboksary; PhD (Medicine), Associate Professor, Senior Research Associate, Laboratory of Experimental and Clinical Pharmacology, Federal D. Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology, and Immunology.
Moscow.
G. K. Albegova
North Ossetia State Medical Academy, Ministry of Health Care.
Russian Federation
Russian Federation
Albegova G.K., PhD, MD, Professor (Medicine), Department of Pharmacology, North Ossetia State Medical Academy, Ministry of Health Care.
Vladikavkaz.
I. G. Kozlov
Russian National N.I. Pirogov Research Medical University; Federal D. Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology, and Immunology.
Russian Federation
Russian Federation
Kozlov I.G., PhD, MD (Medicine), Professor, Head, Department of Pharmacology, Russian National N.I. Pirogov Research Medical University; Chief, Laboratory of Experimental and Clinical Pharmacology, Federal D. Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology, and Immunology.
Moscow.
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Review
For citations:
Kenkishvili A.O., Albegova D.Z., Laptev O.S., Pavlova S.I., Albegova G.K., Kozlov I.G. STUDY OF QUERCETIN DIHYDRATE EFFECTS IN A MODEL OF OVA-INDUCED RESPIRATORY ALLERGY IN MICE. Medical Immunology (Russia). 2017;19(5):629-634. (In Russ.) https://doi.org/10.15789/1563-0625-2017-5-629-634
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