FUNCTIONAL ACTIVITIES OF NEUTROPHILS IN CHRONIC RECURRENT HERPETIC INFECTION
https://doi.org/10.15789/1563-0625-2013-2-169-176
Abstract
Various parameters of neutrophil reactivity, i.e., superoxide anion-forming ability (NВT-test), formation of the extracellular networks (NET) and phagocytic function, were studied in sixty-six patients with
severe form of chronic recurrent herpetic infection. In resting leukocyte cultures from the patients, regardless of the disease stage, NВT scores were higher, and NET values were lower, than in control group. In stimulated cultures, NВT response was decreased, whereas NET parameters were higher than reference values. The changes in NET, but not NВT scores, were more pronounced in patients during the disease exacerbtion and in combined form of herpesvirus infection.
severe form of chronic recurrent herpetic infection. In resting leukocyte cultures from the patients, regardless of the disease stage, NВT scores were higher, and NET values were lower, than in control group. In stimulated cultures, NВT response was decreased, whereas NET parameters were higher than reference values. The changes in NET, but not NВT scores, were more pronounced in patients during the disease exacerbtion and in combined form of herpesvirus infection.
About the Authors
N. V. Gusakova
Gomel State Medical University, Gomel
Russian Federation
PhD candidate, Department of Clinical Laboratory Diagnostics, Allergy and Immunology
Russian Federation
PhD candidate, Department of Clinical Laboratory Diagnostics, Allergy and Immunology
I. A. Novikova
Gomel State Medical University, Gomel
Russian Federation
PhD (Medicine), MD, Professor, Chief, Department of Clinical Laboratory Diagnostics, Allergy and Immunology
Russian Federation
PhD (Medicine), MD, Professor, Chief, Department of Clinical Laboratory Diagnostics, Allergy and Immunology
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Review
For citations:
Gusakova N.V., Novikova I.A. FUNCTIONAL ACTIVITIES OF NEUTROPHILS IN CHRONIC RECURRENT HERPETIC INFECTION. Medical Immunology (Russia). 2013;15(2):169-176. (In Russ.) https://doi.org/10.15789/1563-0625-2013-2-169-176
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