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CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS

https://doi.org/10.15789/1563-0625-2017-3-313-318

Abstract

Thirty-five patients with non-allergic bronchial asthma (NABA), 22 patients with NABA and diabetes mellitus type 2 (DT2), 23 subjects with DT2, and 31 healthy controls were enrolled into the study. ELISA assays for IL-4, IL-10, IL-6, IFNγ were performed by means of a standardized protocol using immunoassay kits purchased from VectorBest, and Cytokine. In asthma patients complicated by DT2, the pattern of bronchial asthma was ascribed to NABA. This finding may be consistent with a theory of specific insulin-receptor interactions in asthma. The NABA patients with type 2 diabetes mellitus exhibited a significant increase in IL-6, IFNγ, and decrease of IL-4, as compared with healthy controls and NABA. Moreover, we have revealed an increase of IL-4, IL-6, IFNγ, when compared with DT2. Hence, the patients with coexistence of non-allergic bronchial asthma and DT2 were characterized by a specific cytokine profile of pro- and anti-inflammatory cytokines, which may correlate with increased glycation and deterioration of lung function.

 

About the Authors

L. N. Sorokina
First St. Petersburg I. Pavlov State Medical University, St. Petersburg
Russian Federation
PhD, MD (Medicine), Professor, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology


V. A. Ivanov
First St. Petersburg I. Pavlov State Medical University, St. Petersburg
Russian Federation
Research Fellow, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology


V. V. Lim
First St. Petersburg I. Pavlov State Medical University, St. Petersburg
Russian Federation
PhD (Medicine), Senior Laboratory Assistant, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology


V. N. Mineev
First St. Petersburg I. Pavlov State Medical University, St. Petersburg
Russian Federation
PhD, MD (Medicine), Professor, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology


V. I. Trofimov
First St. Petersburg I. Pavlov State Medical University, St. Petersburg
Russian Federation
PhD, MD (Medicine), Professor, Head, M.V. Chernorutsky Department of Hospital Therapy with a Course of Allergology and Immunology


References

1. Дедов И.И., Шестакова М.В. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Клинические рекомендации (7-й выпуск) // Проблемы эндокринологии, 2015. Т. 18, № 1. С. 1-112. [Dedov I.I., Shestakova M.V. Algorithms of a specialized medical care for patients with diabetes mellitus. Clinical recommendations (7th release). Problemy endokrinologii = Problems of Endocrinology, 2015, Vol. 18, no. 1, pp. 1-112. (In Russ.)]

2. Колычев А.П., Минеев В.Н., Булатова Н.Ю., Федосеев Г.Б. Особенности инсулин-рецепторных взаимодействий при бронхиальной астме // Пульмонология, 1994. № 2. С. 48-51. [Kolychev A.P., Mineev V.N., Bulatova N.Yu., Fedoseev G.B. The features of insulin – receptor interactions in bronchial asthma. Pulmonologiya = Pulmonology, 1994, no. 2, pp. 48-51. (In Russ.)]

3. Минеев В.Н. Концепция бронхиальной астмы как мембрано-рецепторной патологии // Иммунопатология, аллергология, инфектология, 2005. № 3. С. 68-85. [Mineev V.N. The concept of bronchial asthma as a membrane-receptor pathology Immunopatologiya, allergologiya, infektologiya = Immunopathology, Allergology, Infectology, 2005, no. 3, pp. 68-85. (In Russ.)]

4. Минеев В.Н. Континуумы в клинической медицине // Медицинский академический журнал, 2016. Т. 16, № 3. С. 19-28. [Mineev V.N. The continuums in clinical medicine. Meditsinskiy akademicheskiy zhurnal = Medical Academic Journal, 2016, Vol. 16, no. 3, pp. 19-28. (In Russ.)]

5. Azenabor A., Ogbera A.O., Okafor Ch.J., Adejuwon N. Interplay of T helper 1 and 2 cytokines in type 2 diabetes mellitus with and without microvascular complications. Int. J. Biol. Med. Res., 2011, Vol. 2, no. 4, pp. 917-921.

6. Andrews A.L., Holloway J.W., Holgate S.T., Davies D.E. IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. J. Immunol., 2006, Vol. 176, pp. 7456-7461.

7. Barnes P.J. The cytokine network in asthma and chronic obstructive pulmonary disease. J. Clin. Invest., 2008, Vol. 118, no. 11, pp. 3546-3556.

8. Dennis R.J., Maldonado D., Rojas M.X., Aschner P., Rondon M., Charry L., Casas A. Inadequate glucose control in type 2 diabetes is associated with impaired lung function and systemic inflammation: a cross-sectional study. BMC Pulm. Med., 2010, Vol. 10, no. 1, pp. 38.

9. Kamimura D., Ishihara K., Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. of Physic., Biochem. and Pharmac., 2003, Vol. 149, pp. 1-38.

10. Kelly-Welch A.E. Interleukin-4 and interleukin-13 signaling connections maps. Science, 2003, Vol. 300, no. 5625, pp. 1527-1528.

11. Kicic A., Sutanto E.N., Stevens P.T., Knight D.A., Stick S.M. Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am. J. of Resp. and Critic. Care Med., 2006, Vol. 174, no. 10, pp. 1110-1118.

12. Marini M., Vittori E., Hollemborg J., Mattoli S. Expression of the potent inflammatory cytokines, granulocytemacrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J. of Allergy and Alinic. Immunol., 1992, Vol. 89, no. 5, pp. 1001-1009.

13. Neveu W.A., Allard J.L., Raymond. D.M., Bourassa L.M., Burns S.M., Bunn J.Y., Irvin Ch.G., Kaminsky D.A., Rincon M. Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Resp. Res., 2010, Vol. 11, no. 1, p. 28.

14. O’Connor J.C., Sherry C.L., Guest C.B., Freund G.G. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with over expression of suppressor of cytokine signaling-3. J. of Immunol., 2007, Vol. 177, no. 11, pp. 6886-6893.

15. Pickup J.C., Mattock M.B., Chusney G.D., Burt D. NIDDM as a disease of the innate immune system: association of acutephase reactants and interleukin-6 with metabolic syndrome X. Diabetologia, 1997, Vol. 40, no. 11, pp. 1286-1292.

16. Pradhan A.D., Manson J.E., Rifai N., Buring J.E., Ridker P.M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA, 2001, Vol. 286, no. 3, pp. 327-334.

17. Singh S., Prakash Y.S., Linneberg A., Agrawal A. Insulin and the lung: connecting asthma and metabolic syndrome. J. of Allergy, 2013, Vol. 2013, pp. 1-8.

18. Stalenhoef J.E., Alisjahbana B., Nelwan E.J., Ven-Jongekrijg J., Ottenhoff T.H.M., Meer J.W.M., Nelwan R.H., Netea M.G., Crevel R. The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus. Eur. J. of Clin. Microbiol. and Infect. Dis., 2007, Vol. 27, no. 2, pp. 97-103.

19. Stankiewicz W., Dabrowski M.P., Chcialowski A., Plusa T. Cellular and cytokine immunoregulation in patients with chronic obstructive pulmonary disease and bronchial asthma. Mediators of Inflam., 2002, Vol. 11, no. 5, pp. 307-312.

20. Trayhurn P., Beattie J.H. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc. Nutr. Soc., 2001, Vol. 60, no. 3, pp. 329-339.


Review

For citations:


Sorokina L.N., Ivanov V.A., Lim V.V., Mineev V.N., Trofimov V.I. CYTOKINE PROFILE FEATURES IN THE PATIENTS WITH NONALLERGIC BRONCHIAL ASTHMA WITH CO-EXISTING TYPE 2 DIABETES MELLITUS. Medical Immunology (Russia). 2017;19(3):313-318. (In Russ.) https://doi.org/10.15789/1563-0625-2017-3-313-318

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