TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS
https://doi.org/10.15789/1563-0625-2017-3-267-274
Abstract
Toll-like receptor (TLR) are responsible for recognizing various molecular patterns associated with pathogens. Their expression have been detected in skin cells such as keratinocytes and melanocytes. Numerous experimental studies demonstrate the key role of TLRs in the pathogenesis of immune diseases, including psoriasis. The objective of this study is to analyze the associations of polymorphisms in TLR7 gene and the risk of psoriasis development. DNA samples were collected from 138 patients with psoriasis and 317 healthy controls. Genotyping of rs179003, rs179008, rs179020, rs850632, rs12013728 polymorphic loci in TLR7 gene was performed using the SNPlex™method (AB, USA). SNP in the TLR7 gene rs179008 (Gln11Leu) was associated with psoriasis in entire psoriasis, late onset and sporadic subgroups (Рс = 0.0065, OR = 1.95; Рс = 0.0004, OR = 2.50; Рс = 0.0078, OR = 2.2, respectively). In conclusion, this study is the first to identify genetic variants of the TLR7 gene significantly associated with psoriasis.
About the Authors
E. S. Galimova
Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu, Tartu
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, Russian Federation
Estonia
PhD (Medicine), Senior Research Associate, Laboratory of Human Molecular Genetics, Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, Russian Federation
Estonia
PhD (Medicine), Senior Research Associate, Laboratory of Human Molecular Genetics, Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, Russian Federation
K. Kingo
Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu
Estonia
Professor, Head, Department of Dermatology and Venerology, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu
Estonia
Professor, Head, Department of Dermatology and Venerology, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu
S. Koks
Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu
Estonia
PhD, MD (Medicine), Professor, Head, Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, Faculty of Medicine, University of Tartu, Tartu
Estonia
PhD, MD (Medicine), Professor, Head, Department of Pathophysiology, Institute of Biomedicine and Translation Medicine, Faculty of Medicine, University of Tartu, Tartu
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Review
For citations:
Galimova E.S., Kingo K., Koks S. TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS. Medical Immunology (Russia). 2017;19(3):267-274. (In Russ.) https://doi.org/10.15789/1563-0625-2017-3-267-274
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