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Медицинская иммунология

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КЛЕТОЧНЫЙ ГЕНОМ В ПАТОГЕНЕЗЕ ОСНОВНЫХ ЗАБОЛЕВАНИЙ ЧЕЛОВЕКА (АТЕРОСКЛЕРОЗ, АУТОИММУННЫЕ ЗАБОЛЕВАНИЯ, РАК)

https://doi.org/10.15789/1563-0625-2010-4-5-285-296

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Аннотация

Несмотря на значительные различия в этиологии, патогенезе, клинико-лабораторных данных, наконец, различия в клиническом течении таких заболеваний, как атеросклероз, аутоиммунные и аллергические заболевания накоплены данные, свидетельствующие о том, что в основе этих заболеваний имеется много общего. В первую очередь это касается механизмов эпигенетической регуляции экспрессии генов, характер изменений которой практически тождественен и проявляется тотальным гипометилированием и возвратным гиперметилированием отдельных генов. Схожими при этих патологиях являются также процессы, связанные с регуляцией длины теломер. Все это ставит вопрос о скорейшей разработке методов лечения данных патологий с помощью препаратов, влияющих на молекулярно-биохимические механизмы, лежащих в основе эпигенетической регуляции экспрессии генов.

Об авторе

В. А. Козлов
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Россия


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Для цитирования:


Козлов В.А. КЛЕТОЧНЫЙ ГЕНОМ В ПАТОГЕНЕЗЕ ОСНОВНЫХ ЗАБОЛЕВАНИЙ ЧЕЛОВЕКА (АТЕРОСКЛЕРОЗ, АУТОИММУННЫЕ ЗАБОЛЕВАНИЯ, РАК). Медицинская иммунология. 2010;12(4-5):285-296. https://doi.org/10.15789/1563-0625-2010-4-5-285-296

For citation:


Kozlov V.A. CELLULAR GENOME IN PATHOGENESIS OF BASIC DISEASES IN HUMANS (ATHEROSCLEROSIS, AUTOIMMUNE DISEASES, CANCER). Medical Immunology (Russia). 2010;12(4-5):285-296. (In Russ.) https://doi.org/10.15789/1563-0625-2010-4-5-285-296

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