ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD
https://doi.org/10.15789/1563-0625-2017-2-145-156
Abstract
Conventional strategies for cancer treatment are close to their efficiency limits. Meanwhile, rapid development of experimental immunology and immunotherapy led to first successful experiences in antitumor vaccination. Over last decade, remarkable results were obtained by means of anticancer vaccination being implemented into clinical settings thus causing popularity and growth of interest to tumor-specific DNA vaccines. In this review, we discuss basic principles of a DNA vaccine construction, their structural characteristics and diversity, mechanisms of their biological action, pharmaceutical forms and delivery routes into the body.
About the Authors
M. V. Stegantseva
Belarussian Research Center for Pediatric Oncology, Hematology and Immunology
Belarus
MBs, Junior Research Associate, Laboratory of Molecular Genetic Research
Belarus
MBs, Junior Research Associate, Laboratory of Molecular Genetic Research
A. N. Meleshko
Belarussian Research Center for Pediatric Oncology, Hematology and Immunology
Belarus
PhD (Biology), Head, Laboratory of Molecular Genetic Research
Belarus
PhD (Biology), Head, Laboratory of Molecular Genetic Research
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For citations:
Stegantseva M.V., Meleshko A.N. ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD. Medical Immunology (Russia). 2017;19(2):145-156. (In Russ.) https://doi.org/10.15789/1563-0625-2017-2-145-156
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