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Медицинская иммунология

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КРАТКИЙ ОБЗОР КЛИНИЧЕСКИХ ИСПЫТАНИЙ СРЕДСТВ ИММУНОТЕРАПИИ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ

https://doi.org/10.15789/1563-0625-2017-2-127-144

Аннотация

В течение последнего десятилетия был достигнут большой прогресс в понимании биологии рака и его взаимодействия с иммунной системой. В клинической практике для лечения онкологических заболеваний широко применяются иммунотерапевтические препараты на основе рекомбинантных цитокинов и моноклональных антител, разработано большое количество экспериментальных способов лечения онкологических заболеваний, многие из которых в данный момент проходят различные стадии клинических испытаний. Одобрение рекомбинантного онколитического герпесвируса T-VEC для лечения меланомы стало очередным важным шагом на пути к созданию эффективных и безопасных противораковых препаратов. В данном обзоре мы рассмотрим некоторые наиболее перспективные стратегии иммунотерапии онкологических заболеваний: ингибиторы контрольных точек иммунного ответа, клеточную терапию и онколитические вирусы.

 

Об авторах

Т. С. Непомнящих
ФБУН «Государственный научный центр вирусологии и биотехнологии “Вектор”» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека
Россия
к.б.н., старший научный сотрудник


Д. В. Антонец
ФБУН «Государственный научный центр вирусологии и биотехнологии “Вектор”» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека
Россия
к.б.н., старший научный сотрудник


Р. А. Максютов
ФБУН «Государственный научный центр вирусологии и биотехнологии “Вектор”» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека
Россия
к.б.н., врио генерального директора


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Непомнящих Т.С., Антонец Д.В., Максютов Р.А. КРАТКИЙ ОБЗОР КЛИНИЧЕСКИХ ИСПЫТАНИЙ СРЕДСТВ ИММУНОТЕРАПИИ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ. Медицинская иммунология. 2017;19(2):127-144. https://doi.org/10.15789/1563-0625-2017-2-127-144

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Nepomnyashchikh T.S., Antonets D.V., Maksyutov R.A. SHORT OVERVIEW OF CLINICAL TRIALS WITH CURRENT IMMUNOTHERAPEUTIC TOOLS FOR CANCER TREATMENT. Medical Immunology (Russia). 2017;19(2):127-144. (In Russ.) https://doi.org/10.15789/1563-0625-2017-2-127-144

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