ИММУНОЛОГИЧЕСКИЕ МЕХАНИЗМЫ КОНТРОЛЯ АПОПТОЗА ПРИ РАЗВИТИИ ПЛАЦЕНТЫ
https://doi.org/10.15789/1563-0625-2008-2-3-125-138
Аннотация
Резюме. В настоящем обзоре рассмотрены известные на сегодня сведения о роли иммунологических механизмов контроля процессов апоптоза на разных этапах развития плаценты. Интенсивность процессов апоптоза в человеческой плаценте прогрессивно увеличивается на протяжении всей беременности вплоть до родоразрешения. Индукция и предотвращение апоптоза в клетках плаценты – процессы, неразрывно связанные с развитием плаценты и формированием сосудистого дерева, контролируемые клетками трофобласта, а также клетками иммунной системы матери и плода. Т-лимфоциты, NK-клетки, NKT-клетки и макрофаги осуществляют надзор за процессами ангиогенеза и апоптоза в ткани плаценты, обеспечивая ее нормальное развитие и функционирование. Работа поддержана грантами Президента РФ № НШ-5268.2006.7 и МК-1355.2007.7.
Об авторе
Д. И. Соколов
ГУ НИИ акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-Петербург
Россия
Россия
Лаборатория иммунологии
199282, Санкт-Петербург, ул. Крыленко, 45, корп. 1, кв. 5
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Рецензия
Для цитирования:
Соколов Д.И. ИММУНОЛОГИЧЕСКИЕ МЕХАНИЗМЫ КОНТРОЛЯ АПОПТОЗА ПРИ РАЗВИТИИ ПЛАЦЕНТЫ. Медицинская иммунология. 2008;10(2-3):125-138. https://doi.org/10.15789/1563-0625-2008-2-3-125-138
For citation:
Sokolov D.I. IMMUNOLOGICAL MECHANISMS OF APOPTOSIS IN PLACENTAL DEVELOPMENT. Medical Immunology (Russia). 2008;10(2-3):125-138. (In Russ.) https://doi.org/10.15789/1563-0625-2008-2-3-125-138
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