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Медицинская иммунология

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ИММУНОЛОГИЧЕСКИЕ МЕХАНИЗМЫ КОНТРОЛЯ АПОПТОЗА ПРИ РАЗВИТИИ ПЛАЦЕНТЫ

https://doi.org/10.15789/1563-0625-2008-2-3-125-138

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Аннотация

Резюме. В настоящем обзоре рассмотрены известные на сегодня сведения о роли иммунологических механизмов контроля процессов апоптоза на разных этапах развития плаценты. Интенсивность процессов апоптоза в человеческой плаценте прогрессивно увеличивается на протяжении всей беременности вплоть до родоразрешения. Индукция и предотвращение апоптоза в клетках плаценты – процессы, неразрывно связанные с развитием плаценты и формированием сосудистого дерева, контролируемые клетками трофобласта, а также клетками иммунной системы матери и плода. Т-лимфоциты, NK-клетки, NKT-клетки и макрофаги осуществляют надзор за процессами ангиогенеза и апоптоза в ткани плаценты, обеспечивая ее нормальное развитие и функционирование. Работа поддержана грантами Президента РФ № НШ-5268.2006.7 и МК-1355.2007.7.

Об авторе

Д. И. Соколов
ГУ НИИ акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-Петербург
Россия

Лаборатория иммунологии

199282, Санкт-Петербург, ул. Крыленко, 45, корп. 1, кв. 5

 



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Для цитирования:


Соколов Д.И. ИММУНОЛОГИЧЕСКИЕ МЕХАНИЗМЫ КОНТРОЛЯ АПОПТОЗА ПРИ РАЗВИТИИ ПЛАЦЕНТЫ. Медицинская иммунология. 2008;10(2-3):125-138. https://doi.org/10.15789/1563-0625-2008-2-3-125-138

For citation:


Sokolov D.I. IMMUNOLOGICAL MECHANISMS OF APOPTOSIS IN PLACENTAL DEVELOPMENT. Medical Immunology (Russia). 2008;10(2-3):125-138. (In Russ.) https://doi.org/10.15789/1563-0625-2008-2-3-125-138

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