References

mimmun

Медицинская иммунология

Medical Immunology (Russia)

1563-06252313-741X

SPb RAACI

10.15789/1563-0625-2008-2-3-125-138

mimmun-110

Research Article

ОБЗОРЫ

REVIEWS

ИММУНОЛОГИЧЕСКИЕ МЕХАНИЗМЫ КОНТРОЛЯ АПОПТОЗА ПРИ РАЗВИТИИ ПЛАЦЕНТЫ

IMMUNOLOGICAL MECHANISMS OF APOPTOSIS IN PLACENTAL DEVELOPMENT

Соколов

Д. И.

Sokolov

D. I.

Лаборатория иммунологии

corbie@hotmail.ru

ГУ НИИ акушерства и гинекологии им. Д.О. Отта РАМН, Санкт-ПетербургRussian Federation

2008

15072014

102-3125138

2014

Соколов Д.И.

Sokolov D.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.mimmun.ru/mimmun/article/view/110

Резюме. В настоящем обзоре рассмотрены известные на сегодня сведения о роли иммунологических механизмов контроля процессов апоптоза на разных этапах развития плаценты. Интенсивность процессов апоптоза в человеческой плаценте прогрессивно увеличивается на протяжении всей беременности вплоть до родоразрешения. Индукция и предотвращение апоптоза в клетках плаценты – процессы, неразрывно связанные с развитием плаценты и формированием сосудистого дерева, контролируемые клетками трофобласта, а также клетками иммунной системы матери и плода. Т-лимфоциты, NK-клетки, NKT-клетки и макрофаги осуществляют надзор за процессами ангиогенеза и апоптоза в ткани плаценты, обеспечивая ее нормальное развитие и функционирование. Работа поддержана грантами Президента РФ № НШ-5268.2006.7 и МК-1355.2007.7.

Abstract. In present review, the data are considered that concern a role of immunological mechanisms controlling the events of apoptosis at different stages of development of placenta. Intensity of apoptotic process in human placenta is progressively increasing in the course of pregnancy, until delivery act. The processes of apoptosis induction and its prevention in placental cells are inseparably linked to development of placenta and formation of vascular system, as controlled by trophoblast cells, as well as by maternal fetal immune cells. T-lymphocytes, natural killer cells, NKT-cells and macrophages that perform surveillance over the processes of angiogenesis and apoptosis in placental tissue, thus providing its normal development and functioning.

апоптозангиогенезплаценталимфоцитымакрофаги

apoptosisangiogenesisplacentalymphocytesmacrophagesNKT-cells

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The authors declare that there are no conflicts of interest present.