LYMPHOCYTE-TO PLATELET ADHERENCE IN PATIENTS WITH ERYSIPELAS
https://doi.org/10.15789/1563-0625-2013-2-163-168
Abstract
We observed twenty patients (12 women and 8 men) with erythematous-bullous erysipelas of
moderate grade, and twenty patients (10 men and 10 women) with erythematous form of the disease, 45 to 55 years old. All the patients were diagnosed with primary inflammatory disease located at the lower extremities. The patients were admitted to the hospital within 1 or 3 days from the onset of clinical signs of the disease. In all patients, laboratory studies were performed at 3 and 12 days after clinical onset of the disease. Control group consisted of 55 age- and sex-matched healthy persons. All the patients received standard therapy, including antibiotics, desensitization and detoxifying drugs. Indices of l;ymphocyte-to-platelet adhesion (LPA) were determined in patients with different forms of erysipelas,. It has been found that LPA parameters were sharply
decreased since the beginning of the disease, in spite of near-normal absolute lymphocyte counts, as compared with healthy controls at these terms. A simultaneous reduction in adherence was registered. At day 12, the LPA parameters were increased in the patients, with absence of significant changes in absolute lymphocyte contents against control values, the adhesion rates proved to be increased as well. Hence, a reduced ability of blood lymphocytes to adhere to the surface of platelets was revealed in erysipelas. Dynamics of LPA parameters may serve as an indicator of treatment efficiency.
moderate grade, and twenty patients (10 men and 10 women) with erythematous form of the disease, 45 to 55 years old. All the patients were diagnosed with primary inflammatory disease located at the lower extremities. The patients were admitted to the hospital within 1 or 3 days from the onset of clinical signs of the disease. In all patients, laboratory studies were performed at 3 and 12 days after clinical onset of the disease. Control group consisted of 55 age- and sex-matched healthy persons. All the patients received standard therapy, including antibiotics, desensitization and detoxifying drugs. Indices of l;ymphocyte-to-platelet adhesion (LPA) were determined in patients with different forms of erysipelas,. It has been found that LPA parameters were sharply
decreased since the beginning of the disease, in spite of near-normal absolute lymphocyte counts, as compared with healthy controls at these terms. A simultaneous reduction in adherence was registered. At day 12, the LPA parameters were increased in the patients, with absence of significant changes in absolute lymphocyte contents against control values, the adhesion rates proved to be increased as well. Hence, a reduced ability of blood lymphocytes to adhere to the surface of platelets was revealed in erysipelas. Dynamics of LPA parameters may serve as an indicator of treatment efficiency.
About the Authors
A. N. Emelyanova
Chita State Medical Academy, Chita
Russian Federation
PhD (Medicine), Assistant Professor, Department of Infectious Diseases
Russian Federation
PhD (Medicine), Assistant Professor, Department of Infectious Diseases
Yu. A. Vitkovskiy
Chita State Medical Academy, Chita
Russian Federation
Professor, PhD (Medicine), MD, Chief, Department of Normal Physiology
Russian Federation
Professor, PhD (Medicine), MD, Chief, Department of Normal Physiology
References
1. Валишин Д.А., Абдулов Р.Х., Мухаметов Р.Я., Абдулова Г.Р. Некоторые патогенетические аспекты рожи // Инфекционные болезни. – 2007. – Т. 5, № 2. – С. 29-31. Valishin D.A., Abdulov R.H., Mukhametov R.Ya., Abdulova G.R. Nekotorye patogeneticheskie aspekty rozhi [Some pathogenetic aspects of erysipelas]. Infektsionnye bolezni – Infectious Diseases, 2007, vol. 5, no. 2, pp. 29-31.
2. Витковский Ю.А., Кузник Б.И., Солпов А.В. Модуляция лимфоцитарно-тромбоцитарного взаимодействия интерлейкином-2 // Цитомедины, цитокины и антигены главного комплекса гистосовместимости (HLA): Сборник научных трудов. Выпуск 2. – Чита, 1999. – С. 32-34. Vitkovskiy Yu.A., Kuznik B.I., Solpov A.V. Modulyatsiya limfotsitarno-trombotsitarnogo vzaimodeystviya interleykinom-2 [Lymphocyte-plateletes interactions modulation by inteleukin-2]. Sbornik nauchnykh trudov “Tsitomediny, tsitokiny i antigeny glavnogo kompleksa gistosovmestimosti (HLA)” [Cytomedins, cytokines and major histocompatibility complex antigens (HLA), Research volume]. Chita, 1999, vol. 2, pp. 32-34.
3. Витковский Ю.А., Кузник Б.И., Солпов А.В. Феномен лимфоцитарно-тромбоцитарного розеткообразования // Иммунология. – 1999. – № 4. – С. 35-37. Vitkovskiy Yu.A., Kuznik B.I., Solpov A.V. Fenomen limfotsitarno-trombotsitarnogo rozetkoobrazovaniya [Phenomenon of lymphocyte-thrombocyte rosette formation]. Immunologiya – Immunology, 1999, no. 4, pp. 35-37.
4. Витковский Ю.А, Кузник Б.И., Солпов А.В. Феномен лимфоцитарно-томбоцитарной адгезии // XVIII съезд Физиологического общества им. И.П. Павлова. Тезисы докладов. – Казань. – 25-28 сентября 2001. – С. 319. Vitkovskiy Yu.A, Kuznik B.I., Solpov A.V. Fenomen limfotsitarno-tombotsitarnoy adgezii [Lymphocyte-platelet adhesion phenomena]. XVIII s”ezd Fiziologicheskogo obshchestva im. I.P. Pavlova, Tezisy dokladov [XVII Congress Phisiology society after Pavlov I.P., Thesis Sept. 25-28]. Kazan, 2001, p. 319.
5. Витковский Ю.А., Солпов А.В., Кузник Б.И. Влияние цитокинов на лимфоцитарно-тромбоцитарную адгезию // Медицинская иммунология. – 2002. – Т. 4, № 2. – С. 135-136. Vitkovskiy Yu.A., Solpov A.V., Kuznik B.I. Vliyanie tsitokinov na limfotsitarno-trombotsitarnuyu adgeziyu [Cytokines influence on lymphocyte-plateletes adhesion]. Meditsinskaya immunologiya – Medical Immunology, 2002, vol. 4, no. 2, pp. 135-136.
6. Витковский Ю.А., Солпов А.В., Кузник Б.И. Механизмы лимфоцитарно-тромбоцитарной адгезии // Научные труды I съезда физиологов СНГ. – Сочи, Дагомыс 19-23 сентября 2005. – Т. 1. – С. 299. Vitkovskiy Yu.A., Solpov A.V., Kuznik B.I. Mekhanizmy limfotsitarno-trombotsitarnoy adgezii [Mechanisms of lymphocyte-plateletes adhesion]. Nauchnye trudy I s”ezd fiziologov SNG [Scientific papers I Congress of Physiologists CIS, Dagomys, Sept. 19-23]. Sochi, 2005, vol. 1, p. 299.
7. Витковский Ю.А., Солпов А.В., Кузник Б.И. Тромбоциты усиливают адгезию лимфоцитов к экстрацеллюлярному матриксу // XX съезд Физиологического общества им. И.П. Павлова. Тезисы докладов. – М., 4-8 июня 2007. – С. 178. Vitkovskiy Yu.A., Solpov A.V., Kuznik B.I. Trombotsity usilivayut adgeziyu limfotsitov k ekstratsellyulyarnomu matriksu [Plateletes enforced lymphocytes adhesion to extracellular matrix]. XX s”ezd Fiziologicheskogo obshchestva im. I.P. Pavlova, Tezisy dokladov [XX Congress Phisiology society after Pavlov I.P., Thesis, June 4-8]. Moscow, 2007, p. 178.
8. Гейниц А.В, Дербенёв В.А. Комплексное исследование рожи с использованием физических и физико-химических методов. – М.: Научный мир, 2005. Geynits A.V, Derbeniov V.A. Kompleksnoe issledovanie rozhi s ispol`zovaniem fizicheskikh i fiziko-khimicheskikh metodov [Complex study of erysipelas using physical and physicochemical methods]. Moscow, Nauchnyy mir, 2005.
9. Емельянова А.Н. Влияние биорегулирующей терапии на состояние иммунитета и гемостаза при рожистом воспалении: Автореф. дис. … канд. мед. наук. – М., 2000. Emel`yanova A.N. Vliyanie bioreguliruyushchey terapii na sostoyanie immuniteta i gemostaza pri rozhistom vospalenii. Avtoref. diss. kand. med. nauk [Effect of biocontrol treatment on state immunity and hemostasis with erysipelas. Autoref. Cand. med. sci. diss.]. Moscow, 2000.
10. Кузник Б.И., Цыбиков Н.Н., Витковский Ю.А. Единая гуморальная система защиты организма // Забайкальский медицинский вестник. – 2004. – № 4. – С. 13-19. Kuznik B.I. Tsibikov N.N. Vitkovskiy Yu.A. Edinaya gumoral`naya sistema zashchity organizma [General humoral protective system of organism]. Zabaykal`skiy meditsinskiy vestnik – Transbaikalian Medical Bulletin, 2004, no. 4, pp. 13-19.
11. Кузник Б.И., Цыбиков Н.Н., Витковский Ю.А. Единая клеточно-гуморальная система защиты организма // Тромбоз, гемостаз и реология. – 2005. – Т. 22, № 2. – С. 3-14. Kuznik B.I., Tsibikov N.N., Vitkovskiy Yu.A. Edinaya kletochno-gumoral`naya sistema zashchity organizma [General cellular-humoral protective system of organism]. Tromboz, gemostaz i reologiya – Thrombosis, Hemostasis and Rheology, 2005, vol. 22, no. 2, pp. 3-14.
12. Кузник Б.И., Витковский Ю.А., Солпов А.В. Адгезивные молекулы и лейкоцитарно-тромбоцитарные взаимодействия // Вестник гематологии. – 2006. – Т. 2, № 2. – С. 42-55. Kuznik B.I., Vitkovskiy Yu.A., Solpov A.V. Adgezivnye molekuly i leykotsitarno-trombotsitarnye vzaimodeystviya [Adhesive moleculas and leukocyte-plateletes interactions]. Vestnik gematologii – Bulletin of Hematology, 2006, vol. 2, no. 2, pp. 42-55.
13. Солпов А.В. Влияние про- и противовоспалительных цитокинов на лимфоцитарно-тромбоцитарную адгезию // Забайкальский медицинский вестник. – 2002. – № 1. – С. 14-17. Solpov A.V. Vliyanie pro- i protivovospalitel`nykh tsitokinov na limfotsitarno-trombotsitarnuyu adgeziyu [Pro- and antiinflammatory cytokines influence on lymphocyte-platelet adhesion]. Zabaykal`skiy meditsinskiy vestnik – Transbaikalian Medical Bulletin, 2002, no. 1, pp. 14-17.
14. Солпов А.В. Влияние цитокинов на лимфоцитарно-тромбоцитарную адгезию // Тромбоз, гемостаз, реология. – 2002. – № 1. – С. 34-36. Solpov A.V. Vliyanie tsitokinov na limfotsitarno-trombotsitarnuyu adgeziyu [Cytokines influence on lymphocyte-platelet adhesion]. Tromboz, gemostaz, reologiya – Thrombosis, Hemostasis and Rheology, 2002, no. 1, pp. 34-36.
15. Savion N., Shenkman B., Brill G., Solpov A., Vitkovsky Y., Kuznik B.I., Koltakov A., Kotev-Emeth S., Bank I. Platelets Promote CD4+ Lymphocyte Adhesion to Extracellular Matrix and Fibronectin Under Flow: Role of Integrins, CD40 Ligand and P-Selectin Glycoprotein Ligand-1. Journal of Thrombosis and Haemostasis, 2005, vol. 3, suppl. 1, P0929.
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For citations:
Emelyanova A.N., Vitkovskiy Yu.A. LYMPHOCYTE-TO PLATELET ADHERENCE IN PATIENTS WITH ERYSIPELAS. Medical Immunology (Russia). 2013;15(2):163-168. (In Russ.) https://doi.org/10.15789/1563-0625-2013-2-163-168
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