EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA
https://doi.org/10.15789/1563-0625-2016-5-451-458
Abstract
Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR. In patients with bronchial asthma, (ABA and NABA) we determined a significant increase of mRNA expression levels for a SOCS5 negative transcription regulator in peripheral blood mononuclears, in comparison with control group. Thus, an increase of SOCS5-expression, and of the SOCS3 mRNA expression in patients with BA may be associated with protective anti-inflammatory response.
About the Authors
V. V. Lim
The First St. Petersburg I. Pavlov State Medical University
Russian Federation
Russian Federation
PhD (Medicine), Senior Laborant, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
St. Petersburg
V. A. Ivanov
The First St. Petersburg I. Pavlov State Medical University
Russian Federation
Russian Federation
Postdoc Fellow, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
St. Petersburg
L. N. Sorokina
The First St. Petersburg I. Pavlov State Medical University
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
St. Petersburg
V. N. Mineev
The First St. Petersburg I. Pavlov State Medical University
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
198516, St. Petersburg-Petrodvorets, Sankt-Peterburgskiy ave, 56, apt 15
M. A. Nyoma
The First St. Petersburg I. Pavlov State Medical University
Russian Federation
Russian Federation
PhD (Medicine), Assistant Professor, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
St. Petersburg
V. I. Trofimov
The First St. Petersburg I. Pavlov State Medical University
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Chief, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
St. Petersburg
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Review
For citations:
Lim V.V., Ivanov V.A., Sorokina L.N., Mineev V.N., Nyoma M.A., Trofimov V.I. EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA. Medical Immunology (Russia). 2016;18(5):451-458. (In Russ.) https://doi.org/10.15789/1563-0625-2016-5-451-458
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