CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS
https://doi.org/10.15789/1563-0625-2016-5-437-442
Abstract
The study presents results concerning effects of H3/H4 histamine receptors antagonist (Ciproxifan) upon in vitro chemokine secretion by dendritic cells (DC) and peripheral blood mononuclear cells (PBMC). We have been shown that in vitro inhibition of type H3/H4 histamine receptor affects in different ways production of major chemokines by PBMC and DC, including eotaxin, RANTES, MCP-1, MIP-1α, MIP-1β, GRO-α, and IL-8. E.g., RANTES and GRO-α secretion in DC cultures was reduced, respectively, by 20% and 40%. Meanwhile, MIP-1β secretion was virtually unchanged, whereas MCP-1 secretion exhibited a four-fold increase. In PBMC cultures, the H3/H4 receptor antagonist induced a significant increase in eotaxin, RANTES, MIP-1α, MIP-1β, GRO-α, and IL-8 secretion (p < 0.05).
About the Authors
V. S. Evstratova
Federal Research Center of Nutrition and Biotechnology
Russian Federation
Russian Federation
Junior Research Associate, Laboratory of Immunology,
Moscow
N. A. Riger
Federal Research Center of Nutrition and Biotechnology
Russian Federation
Russian Federation
PhD, MD (Medicine), Senior Research Associate, Laboratory of Immunology,
Moscow
D. B. Nikityuk
Federal Research Center of Nutrition and Biotechnology
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Acting Director,
Moscow
R. A. Khanferyan
Federal Research Center of Nutrition and Biotechnology
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Head, Laboratory of Immunology,
109240, Moscow, Ustyinsky pas., 2/14
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Review
For citations:
Evstratova V.S., Riger N.A., Nikityuk D.B., Khanferyan R.A. CHEMOKINE SECRETION PATTERNS IN MONONUCLEAR AND DENDRITIC CELLS: ROLE OF HISTAMINE TYPE H3/H4 RECEPTORS. Medical Immunology (Russia). 2016;18(5):437-442. (In Russ.) https://doi.org/10.15789/1563-0625-2016-5-437-442
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