INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS
https://doi.org/10.15789/1563-0625-2016-4-365-372
Abstract
The authors propose a new methodological approach to rapid intensity assessment of specific sensitization in acute brucellosis. This technique shows high sensitivity (98%), and specificity (97%). We revealed a direct relation between the intensity of specific IgE-dependent sensitization accompanied by development of immunosuppressive state in patients with brucellosis, i.e., a mean reduction of total CD3+ cell counts by 17.9%; CD3+CD4+ cells, by 13.3%; CD16+CD56+, by 4.4%. Phagocytic ability of blood neutrophils was decreased by 25.8%. The study has shown that an increased reagin-dependent sensitization in brucellosis is closely associated with emergence of severe immunosuppression.
About the Authors
N. S. Sarkisуan
Stavropol Antiplague Institute
Russian Federation
Russian Federation
Laboratory Physician, Clinical Research&Prevention Diagnostic Laboratory,
355035, Stavropol, Sovietskaya str., 13-15
D. G. Ponomarenko
Stavropol Antiplague Institute
Russian Federation
PhD (Biology), Head, Laboratory of Brucellosis and Division of Immunology and Pathomorphology for Special Danger Infections
Russian Federation
PhD (Biology), Head, Laboratory of Brucellosis and Division of Immunology and Pathomorphology for Special Danger Infections
V. O. Logvinenko
Stavropol Antiplague Institute
Russian Federation
PhD (Biology), Senior Research Associate, Head, Division of Immunology and Pathomorphology for Special Danger Infections
Russian Federation
PhD (Biology), Senior Research Associate, Head, Division of Immunology and Pathomorphology for Special Danger Infections
E. L. Rakitina
Stavropol Antiplague Institute
Russian Federation
PhD (Medicine), Leading Research Associate, Division of Immunology and Pathomorphology for Special Danger Infections
Russian Federation
PhD (Medicine), Leading Research Associate, Division of Immunology and Pathomorphology for Special Danger Infections
M. V. Kostyuchenko
Stavropol Antiplague Institute
Russian Federation
Research Associate, Division of Immunology and Pathomorphology for Special Danger Infections
Russian Federation
Research Associate, Division of Immunology and Pathomorphology for Special Danger Infections
A. N. Kulichenko
Stavropol Antiplague Institute
Russian Federation
PhD, MD (Medicine), Professor, Director
Russian Federation
PhD, MD (Medicine), Professor, Director
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Review
For citations:
Sarkisуan N.S., Ponomarenko D.G., Logvinenko V.O., Rakitina E.L., Kostyuchenko M.V., Kulichenko A.N. INTENSITY OF SPECIFIC SENSITIZATION AND IMMUNE PROFILE IN PATIENTS WITH BRUCELLOSIS. Medical Immunology (Russia). 2016;18(4):365-372. (In Russ.) https://doi.org/10.15789/1563-0625-2016-4-365-372
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