A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA
https://doi.org/10.15789/1563-0625-2016-2-183-186
Abstract
The aim of present study was to evaluate a possible role of Id2 (inhibitor of DNA-binding 2) in pathogenesis of bronchial asthma (BA). We have examined six healthy control persons, nine patients with allergic bronchial asthma (ABA) and twenty-four patients with non-allergic bronchial asthma (NABA). The Id2 mRNA expression was evaluated by means of real-time PCR.
No significant differences in Id2 mRNA expression levels were revealed between the control and asthma groups. Correlation analysis of Id2 mRNA expression has revealed significant positive correlation with AID (activation-induced cytidine deaminase) mRNA levels and peripheric blood eosinophil contents in ABA. Healthy persons demonstrate strong positive correlation between Id2 mRNA expression and serum IgE levels, like as with ε-chain mRNA contents.
It was suggested that the Id2 dysfunction may take place in the BA patients. These changes affect negative control over the AID expression, which is important for switching B-cells to IgE production.
About the Authors
V. N. Mineev
The First St. Petersburg I. Pavlov State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
198516, St. Petersburg-Petrodvorets, Sankt-Peterburgskiy pr., 56, apt 15
M. A. Nyoma
The First St. Petersburg I. Pavlov State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
PhD, MD (Medicine), Assistant Professor, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
St. Petersburg
L. N. Sorokina
The First St. Petersburg I. Pavlov State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
PhD (Medicine), Associate Professor, M. Chernorutsky Hospital Therapy Department with a Course of Allergology and Immunology,
St. Petersburg
References
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Review
For citations:
Mineev V.N., Nyoma M.A., Sorokina L.N. A PATHOGENETIC ROLE OF TRANSCRIPTION COREPRESSOR Id2 IN BRONCHIAL ASTHMA. Medical Immunology (Russia). 2016;18(2):183-186. (In Russ.) https://doi.org/10.15789/1563-0625-2016-2-183-186
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