MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES
https://doi.org/10.15789/1563-0625-2016-2-163-170
Abstract
Specific perinatal infections make about 30% in causal structure of infant mortality. Among the respiratory diseases of perinatal period, pneumonias take a special place, due to higher frequency, severity, complications and adverse outcomes. The aim of this work was to study microflora and factors of innate immunity (TLR2, TLR4, HBD-1, HBD-2, TNFα and NF-kB) at the level of the mucous membranes of the upper respiratory tract during intrauterine infection of fetus and perinatal pneumonia. Causal structure of ventilator-associated pneumonias at the intensive care unit represents a broad spectrum of pathogens with high resistance to antibiotics. Changes of immunological parameters (recognizing structures, i.e., TLR2, TLR4, HBD-1; HBD-2 defensins; proinflammatory TNFα cytokine and NF-kB transcription factor) in patients with intrauterine infections and pneumonia are ambiguous. Decreased expression of TLR2, TLR4 genes, along with increased of TNFα and NF-kB gene expression. These changes correlate with type of infectious pathogen, thus allowing us to assume that the pathogen, due to pathogenicity factors, may directly affect innate immunity mechanisms.
About the Authors
O. A. Svitich
I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation
Russian Federation
PhD, MD (Medicine), Chief, Laboratory of Molecular Immunology,
123557, Moscow, Zoologichesky Lane, 8, 100
S. M. Omarova
Dagestan State Medical Academy
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Department of Microbiology,
Makhachkala, Dagestan
A. I. Alieva
Dagestan State Medical Academy
Russian Federation
Russian Federation
PhD (Medicine), Associate Professor, Department of Microbiology,
Makhachkala, Dagestan
N. D. Rasskazova
I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation
Russian Federation
Junior Research Associate, Laboratory of Molecular Immunology,
Moscow
V. V. Zverev
I. Mechnikov Research Institute of Vaccines and Sera
Russian Federation
Russian Federation
PhD, MD (Biology), Professor, Full Member, Russian Academy of Sciences, Director,
Moscow
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For citations:
Svitich O.A., Omarova S.M., Alieva A.I., Rasskazova N.D., Zverev V.V. MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES. Medical Immunology (Russia). 2016;18(2):163-170. (In Russ.) https://doi.org/10.15789/1563-0625-2016-2-163-170
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