TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS
https://doi.org/10.15789/1563-0625-2016-1-91-96
Abstract
An experimental model of post-traumatic arthritis of knee was developed in a series of 105 white non-inbred rats. Time-dependent changes of some cytokines were studied upon combined treatment with oral nimesulide and intra-articular etoxydole injections. It was found that the knee joint injury we observed increased levels of pro- and anti-inflammatory cytokines, which may reflect a development of local immunological response. Combined application of nimesulide and etoxydole contributed to significant reduction in all cytokine pools at the end of observation, bringing their levels to normal ranges typical to the intact animals.
About the Authors
A. N. Zahvatov
N.P. Ogarev State Medical University
Russian Federation
Russian Federation
hD (Medicine), Associate Professor, N.I. Atyasov Department of General Surgery with a Course of Otorhinolaryngology,
431510, Republic of Mordovia, Lyambir, Lenin str., 53-17
S. A. Kozlov
N.P. Ogarev State Medical University
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, N.I. Atyasov Department of General Surgery with a Course of Otorhinolaryngology,
Saransk
N. A. Atkina
N.P. Ogarev State Medical University
Russian Federation
Russian Federation
Medical Student (4th acad. year),
Saransk
I. I. Dudorov
N.P. Ogarev State Medical University
Russian Federation
Russian Federation
Postdoc Fellow, N.I. Atyasov Department of General Surgery with a Course of Otorhinolaryngology, Stomatology and Maxillofacial Surgery,
Saransk
References
1. Берглезов М.А., Андреева Т.М. Остеоартроз (этиология, патогенез) // Вестник травматологии и ортопедии им. Н.Н. Приорова, 2006. № 4. С. 79-86. [Berglezov M.A., Andreeva T.M. Osteoarthritis (etiology, pathogenesis). Vestnik travmatologii i ortopedii im. N.N. Priorova = N.N. Priorov Bulletin of Traumatology and Orthopedics, 2006, no. 4, рр. 79-86. (In Russ.)]
2. Дубровин Г.М., Блинков Ю.А., Нетяга С.В., Нетяга А.А. Обоснование применения миелопида для профилактики посттравматического остеоартроза (экспериментальное исследование) // Вестник травматологии и ортопедии им. Н.Н. Приорова, 2005. № 2. С. 60-62. [Dubrovin G.M., Blinkov U.A., Netyaga S.V., Netyaga A.A. The rationale for the use of mielopid for the prevention of posttraumatic osteoarthritis (experimental study). Vestnik travmatologii i ortopedii im. N.N. Priorova = N.N. Priorov Bulletin of Traumatology and orthopedics, 2005, no. 2, рр. 60-62. (In Russ.)]
3. Есина Е.Ю. Новые подходы к терапии остеоартроза // ИнВестРегион, 2008. № 2. С. 48-50. [Esina E.Yu. New approaches to the treatment of osteoarthritis. InVestRegion = Investigation, 2008, no. 2, pp. 48-50. (In Russ.)]
4. Королева С.В., Львов С.Е., Григорьев Э.В., Мясоедова С.Е. Медикаментозное лечение остеоартроза // Травматология и ортопедия России, 2006. № 3. С. 76-81. [Korolevа S.V., Lvov S.E., Grigoriev E.V., Myasoedova S.E. Medical treatment of osteoarthritis (review of literature). Travmatologiya i ortopediya Rossii = Traumatology and Orthopedics of Russia, 2006, no. 3, рр. 76-81. (In Russ.)]
5. Миронов С.П., Ветрилэ С.Т., Космиади Г.А., Швец В.В. Роль клеток иммунной системы в дегенеративных изменениях межпозвонкового диска // Вестник травматологии и ортопедии им. Н.Н. Приорова, 2007. № 3. С. 16-22. [Mironov S.P., Vetrile S.T., Kosmiadi G.A., Shvets V.V. Role of immune cells in degenerative changes of the intervertebral disc. Vestnik travmatologii i ortopedii im. N.N. Priorova = N.N. Priorov Bulletin of Traumatology and Orthopedics, 2007, no. 3, рр. 16-22. (In Russ.)]
6. Фатеева Е.И., Скачилова С.Я., Митрохин Н.М. Липидрегулирующая активность нового оригинального производного 3-оксипиридина (этоксидола) // Кубанский научный медицинский вестник, 2008. № 6 (105). С. 84-86.[ Fateev E.I., Skahcilova S.J., Mitrokhin N.M. Operagoers activity new original derived 3-hydroxypyridine (etoxazole). Kubanskiy nauchnyy meditsinskiy vestnik = Kuban Research Medical Journal, 2008, no. 6 (105), pp. 84-86. (In Russ.)]
7. Derry S., Loke Y.K. Risk of gastrointestinal haemorrage with long term use of aspirin. BMJ, 2000, no. 321, pp. 1183-1187.
8. Hogue J.H., Mersfelder T.L. Pathophysiology and first-line treatment of osteoarthritis. The Annals of Pharmacotherapy, 2002, Vol. 36, no. 4, pp. 679-686.
9. Savage R. Cyclo-oxygenase-2 inhibitors: when should. They be used in the elderly. Drugs Aging, 2005, Vol. 22, no. 3, pp. 185-200.
Review
For citations:
Zahvatov A.N., Kozlov S.A., Atkina N.A., Dudorov I.I. TIME COURSE OF CYTOKINE LEVELS IN EXPERIMENTAL POSTTRAUMATIC ARTHRITIS. Medical Immunology (Russia). 2016;18(1):91-96. (In Russ.) https://doi.org/10.15789/1563-0625-2016-1-91-96
Views:
979
Email this article 