SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES
https://doi.org/10.15789/1563-0625-2016-1-7-14
Abstract
The issues of immune pathogenesis in autoimmune pathology are discussed in this review. The main attention is drawn to potential pathogenetic role of various suppressor cell populations, including T-regulatory cells, mesenchymal stem cells, myeloid lineage-derived suppressors. Homeostatic lymphocyte proliferation is considered to be of great importance for pathogenesis of autoimmune disorders. Recent data from literature suggest that the autoimmune diseases are characterized by reduced activity of the mentioned suppressor cell populations, thus being a possible prerequisite for development of autoaggressive clones of cytotoxic lymphocytes, increased synthesis of autoantibodies leading to evolving autoimmune pathology. It should be, however, noted, that all these processes are accompanied by changes in the immune system induced by homeostatic proliferation of lymphoid cells.
About the Author
V. A. Kozlov
Research Institute of Fundamental and Clinical Immunology
Russian Federation
Russian Federation
Professor, Full Member of the Russian Academy of Sciences, Director,
630099, Novosibirsk, Yadrintsevskaya str., 14
References
1. Козлов В.А. Гомеостатическая пролиферация лимфоцитов в аспекте иммунопатогенеза различных заболеваний // Иммунология, 2006. Т. 27, № 6. С. 378-382. [Kozlov V.A. Homeostatistic lymphocyte proliferation in immunopathogenesis aspect of different diseases. Immunologiya = Immunology, 2006, Vol. 27, no. 6, pp. 378-382. (In Russ.)]
2. Цырлова И.Г., Кашлакова Н.В., Козлов В.А. Влияние клеток «эритропоэтической» селезенки на пролиферацию Т- и В-лимфоцитов // Иммунология, 1986. № 4. С. 27-29. [Tsyrlova I.G., Kashlakova N.V., Kozlov V.A. Influence of the “erythropoietic” spleen cells on T- and B-lymphocyte proliferation. Immunologiya = Immunology, 1986, no. 4, pp. 27-29. (In Russ.)]
3. Andersen M.H. Potential roles of self-reactive T cells in autoimmunity: lesson from cancer immunology. J. Immunol. Res., 2014, Vol. 60, no. 2-3, pp. 156-164.
4. Bacigalupo A., Valle M., Podesta M., Pitto A., Zocchi E., De Flora A., Pozzi S., Luchetti S., Frassoni F., Van Lint M.T., Piaggio G. T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia. Exp. Hematology, 2005, Vol. 33, no. 7, pp. 819-827.
5. Becker J.C., Straten P.Th., Andersen M.H. Self-reactive T cells: suppressing the suppressors. Cancer Immunol. Immunother, 2014, Vol. 63, no. 4, pp. 313-319.
6. Blanco P., Palucka A.K., Gill M., Pascual V., Banchereau J. Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus. Science, 2001, Vol. 294, no. 5546, pp. 1540-1543.
7. Bouffi C., Djouad F., Mathieu M., Noеl D., Jorgensen C. Multipotent mesenchymal stromal cells and rheumatoid arthritis: risk or benefit. Rheumatology, 2009, Vol. 48, no. 10, pp. 1185-1189.
8. Bucker J.H. Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol., 2010, Vol. 10, no. 12, pp. 849-859.
9. Candando K.M., Lykken J.M., Tedder T.F. B10 cell regulation of health and disease. Immunological Reviews, 2014, Vol. 259, pp. 259-272.
10. Chan J.L., Tang K.C., Patel A.P, Bonilla L.M., Pierobon N., Ponzo N.M., Rameshwar P. Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ. Blood, 2006, Vol. 107, pp. 4817-4824.
11. Cripps J.G., Gorham J.D. MDSC in autoimmunity. Int. Immunopharmacol., 2011, Vol. 11, no. 7, pp. 789-793.
12. Crook K.R., Jin M., Weeks M.F., Rampersad R.R., Baldi R.M., Glekas A.S., Shen Y., Esserman D.A., Little P., Schwartz T.A., Liu P. Myeloid-derived suppressor cells regulate T cell and B cell responses during autoimmune disease. J. Leukocyte Biology, 2015, Vol. 97, no. 3, pp. 573-582.
13. Delgoffe G.M., Woo S-R., Turnis M.E., Gravano D.M., Guy C., Overacre A.E., Bettini M.L., Vogel P., Finkelstein D., Bonnevier J., Workman C.J., Vignali D.A. Stability and function of regulatory T cells is maintained by a neurophilin-1-semaphorin-4a axis. Nature, 2013, Vol. 501, pp. 252-256.
14. Dilek N., Porier N., Hulin P., Mary C., Ville S., Vie H., Clemenceau B., Blancho G. Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells. PLoS One, 2013, Vol. 8, no. 12, pp. 1-14.
15. Djouad F., Bouffi C., Ghannam S., Noеl D., Jorgensen C. Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat. Rev. Rheumatol., 2009, Vol. 5, pp. 392-399.
16. Fan H., Zhao G., Liu L., Liu F., Gong W., Liu X., Yang L., Wang J., Hou Y. Pre-treatment with IL-1b enhances the efficacy of MSC transplantation in DSS-induced colitis. Cellular and Molecular Immunology 2012, Vol. 9, pp. 473-481.
17. Fujii W., Ashihara E., Hirai H., Nagahara H., Kajitani N., Fujioka K., Murakami K., Seno T., Yamamoto A., Ishino H., Kohno M., Maekawa T., Kawahito Y. Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis. J. Immunol., 2013, Vol. 191, pp. 1073-1081.
18. Gabrilovich D.I., Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol., 2009, Vol. 9, no. 3, pp. 162-74.
19. Hafler D.A., Buchsbaum M., Weiner H.L. Decreased autologous mixed lymphocyte reaction in multiple sclerosis. J. Neuroimmunology, 1985, Vol. 9, pp. 339-347.
20. Haniffa M.A., Wang X-N., Holtick U., Rae M., Isaacs J.D., Dickinson A.M., Hilkens C.M.U., Collin M.P. Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J. Immunol., 2007, Vol. 179, pp. 1595-1604.
21. Herrero C., Perez-Simon J.A. Immunomodulatory effect of mesenchymal stem cells. Braz. J. Med. Biol. Res., 2010, Vol. 43, no. 5, pp. 425-430.
22. Jones S., Horwood N., Cope A., Dazzi F. The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells. J. Immunol., 2007, Vol. 179, no. 5, pp. 2824-2831.
23. Kalampokis I., Yoshizaki A., Tedder T.F. IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Research and Therapy, 2013, Vol. 15, Suppl. 1, pp. 1-12.
24. Kawashiri S.-Y., Kawashiri A., Okada A., Koga T., Tamai M., Yamasaki S., Nakamura H., Origuchi T., Ida H., Eguchi K. CD4+CD25highCD127low/- Treg cell frequency from peripheral blood correlates with disease activity in patients with rheumatoid arthritis. J. Rheumatol., 2011, Vol. 38, no. 12, pp. 2517-2521.
25. Liotta F., Angeli R., Cosmi L., Filì L., Manuelli C., Frosali F., Mazzinghi B., Maggi L., Pasini A., Lisi V., Santarlasci V., Consoloni L., Angelotti M.L., Romagnani P., Parronchi P., Krampera M., Maggi E., Romagnani S., Annunziato F. Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling. Stem Cells, 2008, Vol. 26, no. 1, pp. 279-289.
26. Liu L.H., Chen B., Sun Z., Ye L.P., Shi B., Jin J.G., Zhao C.H. Immuno-suppressive effects on T cells mediated by mesenchymal stem cells from patients with myelodysplastic syndrome. J. Exp. Hematology, 2008, Vol. 16, no. 2, pp. 299-304.
27. Marleau A.M., Sarvetnick N. T cell homeostasis in tolerance and immunity. J. Leuk. Biology, 2005, Vol. 78, no. 3, pp. 575-584.
28. Mimran A., Cohen I.R. Regulatory T cells in autoimmune diseases: anti-ergotypic T cells. Int. Rev. Immunol., 2005, Vol. 24, no. 3-4, pp. 159-179.
29. Miyara M., Gorochov G., Ehrenstein M., Musset L., Sakaguchi S., Amoura Z. Human FoxP3+ regulatory T cells in systemic autoimmune diseases. Autoimmunity Reviews, 2011, Vol. 10, no. 12, pp. 744-755.
30. Nakano S., Morimoto S., Suzuki S., Tsushima H., Yamanaka K., Sekigawa I., Takasaki Y. Immunoregulatory role of IL-35 in T cells of patients with rheumatoid arthritis. Rheumatology, 2015, 1-9 pii: keu528.
31. Nie H., Zheng Y., Li R., Guo T.B., He D., Fang L., Liu X., Xiao L., Chen X., Wan B., Chin Y.E., Zhang J.Z. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNFα in rheumatoid arthritis. Nat. Med., 2013, Vol. 19, no. 3, pp. 322-328.
32. Noеl D., Djouad F., Bouffi C., Mrugala D., Jorgensen C. Multipotent mesenchymal stromal cells and immune tolerance. Leukemia and Lymphoma, 2007, Vol. 48, no. 7, pp. 1283-1289.
33. Perez-Simon J.A., Tabera S., Sarasquete M.E., Diez-Campelo M., Canchado J., Sánchez-Abarca L.I., Blanco B., Alberca I., Herrero-Sánchez C., Cañizo C., San Miguel J.F. Mesenchymal stem cells are fuctionally abnormal in patients with immune thrombocytopenic purpura. Cytotherapy, 2009, Vol. 11, no. 6, pp. 698-705.
34. Peterson R.A. Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression. Toxicologic Phatology, 2012, Vol. 40, no. 2, pp. 186-204.
35. Prendergast G.C., Metz R., Muller A.J., Merlo L.M., Mandik-Nayak L. IDO2 in Immunomodulation and Autoimmune Disease. Front Immunol., 2014, no. 5, p. 585.
36. Quintana F.J., Cohen I.R. Anti-ergotypic immunoregulation. Scand. J. Immunol., 2006, Vol. 64, no. 3, pp. 205-210.
37. Surh C.D., Sprent J. Homeostasis of naive and memory T cells. Immunity. 2008, Vol. 29, no. 6, pp. 848-862.
38. Valenca X., Stephens G., Goldbach-Mansky R., Wilson M., Shevach E.M., Lipsky P.E. TNF downmodulation the function of human CD4+CD25hi T-regulatory cells. Blood, 2006, Vol. 108, no. 1, pp. 253-261.
39. Vogel I., Kasran A., Cremer J., Kim Y-J., Boon L., Van Gool S.W., Ceuppens J.L. CD28/CTLA/B7 costimulatory pathway blockade affects regulatory T-cell function in autoimmunity. Eur. J. Immunol., 2015, pp. 1-10.
40. Yoshizaki A., Miyagaki T., DiLillo D.J., Matsushita T., Horikawa M., Kountikov E.I. Spolski R., Poe J.C., Leonard W.J., Tedder T.F. Regulatory B cells control T cell autoimmunity through IL-21-dependent cognate interactions. Nature, 2012, Vol. 491, no. 7423, pp. 264-268.
41. Yi H., Guo C., Yu X., Zuo D., Wang X.Y. Mouse CD11b+Gr-1+ myeloid cells can promote Th17 cell differentiation and experimental autoimmune encephalomyelitis. J. Immunol., 2012, Vol. 189, no. 9, pp. 4295-4304.
Review
For citations:
Kozlov V.A. SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES. Medical Immunology (Russia). 2016;18(1):7-14. (In Russ.) https://doi.org/10.15789/1563-0625-2016-1-7-14
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