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CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS

https://doi.org/10.15789/1563-0625-2013-2-147-154

Abstract

 To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology,  sixty patients have been examined  in  five equal groups, i.e., BA; hypothyroidism;  thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more  frequently  in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged  in BA patients,  than  in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum  IgE  levels were much  increased  in  the group with BA + hyperthyroidism. The  lowest IL-4/IFNγ ratio was revealed  in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher  in BA + hyperthyroidism group,  than  in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions
dominating  in BA, whereas concomitant hypothyroidism may cause  a  reduction of Th2  immune  response.

About the Authors

I. A. Kamaeva
St. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. Petersburg
Russian Federation
Assistant Professor, Department of General Medical Practice (Family Medicine)


N. L. Shaporova
St. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. Petersburg
Russian Federation
PhD (Medicine), MD, Professor, Chief, Department of General Medical Practice (Family Medicine)


I. M. Gaiduk
St. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. Petersburg
Russian Federation
PhD (Medicine), Associate Professor, Department of General Medical Practice (Family Medicine)


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For citations:


Kamaeva I.A., Shaporova N.L., Gaiduk I.M. CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS. Medical Immunology (Russia). 2013;15(2):147-154. (In Russ.) https://doi.org/10.15789/1563-0625-2013-2-147-154

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ISSN 1563-0625 (Print)
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