CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
https://doi.org/10.15789/1563-0625-2013-2-147-154
Abstract
To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology, sixty patients have been examined in five equal groups, i.e., BA; hypothyroidism; thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more frequently in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged in BA patients, than in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum IgE levels were much increased in the group with BA + hyperthyroidism. The lowest IL-4/IFNγ ratio was revealed in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher in BA + hyperthyroidism group, than in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions
dominating in BA, whereas concomitant hypothyroidism may cause a reduction of Th2 immune response.
About the Authors
I. A. Kamaeva
St. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. Petersburg
Russian Federation
Assistant Professor, Department of General Medical Practice (Family Medicine)
Russian Federation
Assistant Professor, Department of General Medical Practice (Family Medicine)
N. L. Shaporova
St. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. Petersburg
Russian Federation
PhD (Medicine), MD, Professor, Chief, Department of General Medical Practice (Family Medicine)
Russian Federation
PhD (Medicine), MD, Professor, Chief, Department of General Medical Practice (Family Medicine)
I. M. Gaiduk
St. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. Petersburg
Russian Federation
PhD (Medicine), Associate Professor, Department of General Medical Practice (Family Medicine)
Russian Federation
PhD (Medicine), Associate Professor, Department of General Medical Practice (Family Medicine)
References
1. Ильина О.Ю. Особенности развития, клиники и течения бронхиальной астмы в сочетании с патологией щитовидной железы: Автореф. дис. …канд. мед. наук. – СПб., 2006. – 11 с. Il`ina O.Yu. Osobennosti razvitiya, kliniki i techeniya bronkhial`noy astmy v sochetanii s patologiey shchitovidnoy zhelezy. Avtoref. diss. kand. med. nauk [Features of development, clinic and bronchial asthma with pathology of the thyroid gland. Autoref. Cand. med. sci. diss.]. St. Petersburg, 2006. 11 p.
2. Попова Н.В., Бондарь И.А., Куделя Л.М. Особенности бронхиальной астмы у больных с первич-ным гипотиреозом // Медицина и образование в Сибири. – 2010. – № 5. – С.89-92. Popova N.V., Bondar` I.A., Kudelya L.M. Osobennosti bronkhial`noy astmy u bol`nykh s pervichnym gipotireozom [Bronchial asthma features in initial hypothyroidism patients]. Meditsina i obrazovanie v Sibiri – Medicine and Education in Siberia, 2010, no. 5, pp. 89-92.
3. Семенова Н.В. Клинико-патогенетические аспекты сочетания бронхиальной астмы с аутоимунным тиреоидитом: Автореф. дис. ... канд. мед. наук. – М., 1998. – 24 с. Semenova N.V. Kliniko-patogeneticheskie aspekty sochetaniya bronkhial`noy astmy s autoimunnym tireoiditom. Avtoref. diss. kand. med. nauk [Clinical and pathogenetic aspects of bronchial asthma and autoimmune thyroiditis combination. Autoref. Cand. med. sci. diss.]. Moscow, 1998. 24 p.
4. Федосеев Г.Б., Трофимов В.И. Бронхиальная астма. – СПб.: Нордмедиздат, 2006. – 308 с. Fedoseev G.B., Trofimov V.I. Bronkhial`naya astma [Bronchial asthma]. St. Petersburg, Nordmedizdat – Nordmedizdat, 2006. 308 p.
5. Фрейдлин И.С., Тотолян А.А. в кн. «Общая Аллергология». Т. 1 / Под ред. Г.Б. Федосеева. – СПб.: Нордмедиздат, 2001. – С. 190-340. Freydlin I.S., Totolian Areg A. v knige «Obshchaya Allergologiya». Pod redaktsiey G.B. Fedoseeva [in General Allergology. Ed.: Fedoseev G.B.]. St. Petersburg, Nordmedizdat – Nordmedizdat, 2001, vol. 1, pp. 190-340.
6. Шубина О.В. Клинико-иммунологические особенности течения бронхиальной астмы в сочетании гипотиреозом: Автореф. дис. ... канд. мед. наук. – М., 2010. – 14 с. Shubina O.V. Kliniko-immunologicheskie osobennosti techeniya bronkhial`noy astmy v sochetanii gipotireozom. Avtoref. diss. kand. med. nauk [Immunological and clinical features of bronchial asthma in combination with hypothyroidism. Autoref. Cand. med. sci. diss.]. Moscow, 2010. 14 p.
7. Bendtzen K., Buschard K., Diamant M., Horn T., Svenson M. Possible role of IL-1, TNF-alpha, and IL-6 in insulin-dependent diabetes mellitus and autoimmune thyroid disease. Lymphokine Res., 1989, vol. 8, no. 3, pp. 335-340.
8. Colavita A.M., Reinach A.J., Peters S.P. Contributing factors to the pathobiology of asthma. The Th1/Th2 paradigm. Clin. Chest Med., 2000, vol. 21, no. 2, pp. 263-277.
9. Global Initiative for Asthma. Global strategy for Asthma. Management and Prevention. 2010 update. www.ginasthma.com/Guidelineitem.asp.
10. Hirooka Y., Kayama M., Ohga S., Kimura M., Hasegawa M., Shin K., Nogimori T., Ishizuki Y., Mitsuma T. Deregulated production of interleukin- (IL4) in autoimmune thyroid disease assayed with a new radioimmunoassay. Clin. Chim. Acta, 1993, vol. 216, no. 1-2, pp. 1-10.
11. Kocjan T., Wraber B., Kocijancic A., Hojker S. Methimazole upregulates T-cell-derived cytokines without improving the existing Th1/Th2 imbalance in Graves’ disease. J. Endocrinol. Invest., 2004, vol. 27, no. 4, pp. 302-307.
12. Manzolli S., Macedo-Soares M.F., Vianna E.O., Sannomiya P. Allergic airway inflammation in hypothyroid rats. J. Allergy Clin. Immunol., 1999, vol. 104, no. 3, pt 1, pp. 595-600.
13. Masoli M., Fabian D., Holt S., Beasley R. Global Initiative for Asthma (GINA) Program. Allergy, 2004, vol. 59, no. 5, pp. 469-478.
14. Phenekos C., Vryonidou A., Gritzapis A.D., Baxevanis C.N., Goula M., Papamichail M. Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto’sthyroiditis (Th1) and Graves’ disease (Th2). Neuroimmunomodulation, 2004, vol. 11, no. 4, pp. 209-213.
15. Rasmussen A.K., Bendtzen K., Feldt-Rasmussen U. Thyrocyte-interleukin-1 interactions. Exp. Clin. Endocrinol. Diabetes, 2000, vol. 108, no. 2, pp. 67-71.
16. Sato A., Takemura Y., Yamada T., Ohtsuka H., Sakai H., Miyahara Y., Aizawa T., Terao A., Onuma S., Junen K., Kanamori A., Nakamura Y., Tejima E., Ito Y., Kamijo K. A possible role of immunoglobulin E in patients with hyperthyroid Graves’ disease. J. Clin. Endocrinol. Metab., 1999, vol. 84, no. 10, pp. 3602-3605.
17. Ueda M., Ichiyama S., Sugawa H. Thyroid specific T helper cell analysis by ELISPOT assay with thyrotropin receptor (TSH-R) peptides. Peptides, 2002, vol. 23, no. 1, pp. 103-107.
18. Yamada T., Sato A., Komiya I., Nishimori T., Ito Y., Terao A., Eto S., Tanaka Y. An elevation of Serum Immunoglobulin E Provides a New aspect of Hyperthyroid Graves Disease. J. Clin. Endocrinol. Metab., 2000, vol. 85, no. 8, pp. 2775-2778.
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For citations:
Kamaeva I.A., Shaporova N.L., Gaiduk I.M. CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS. Medical Immunology (Russia). 2013;15(2):147-154. (In Russ.) https://doi.org/10.15789/1563-0625-2013-2-147-154
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