CANCER IMMUNOTHERAPY BASED ON THE BLOCKADE OF IMMUNE CHECKPOINTS
https://doi.org/10.15789/1563-0625-2015-5-395-406
Abstract
Immune checkpoints represent the system of inhibitory mechanisms regulating the activation of the immune response, preventing the autoimmune processes and modulating the immune response by decreasing the immune cell-mediated damage of tissues and organs. Tumor cells may utilize these checkpoints to prevent the activation of tumor-specific lymphocytes, thereby acquiring resistance against the immune response. The blockade of inhibitory signal that is transduced in immune checkpoints leading to the reactivation of antitumor immune response is a promising method of tumor immunotherapy. Since the majority of immune checkpoints are based on the ligand-receptor interactions, one of contemporary modalities of anti-tumor therapy is based on the development of ligandor receptor-blocking therapeutic monoclonal antibodies, as well as soluble recombinant receptors capable of competing for a ligand and thereby modulating the signal transduction. In the past few years, this field of tumor immunotherapy experienced an impressive success; however, the potential tradeoff for altering of the natural suppressive mechanisms is the development of the autoimmune reactions.
About the Authors
A. V. Bogolyubova
Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow;
Moscow State University
Russian Federation
Russian Federation
Junior Research Associate, Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences; Department of Immunology, Faculty of Biology, Moscow State University;
Address for correspondence: Bogolyubova Apollinariya V. Engelhardt Institute of Molecular Biology of Russian Academy of Sciences 119991, Russian Federation, Moscow, Vavilov str., 32. Phone: 7 (499) 135-99-64. Fax: 7 (499) 135-14-05. E-mail: apollinariya.bogolyubova@gmail.com
G. A. Efimov
Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow;
National Research Center for Hematology, Moscow
Russian Federation
PhD (Biology), Head, Laboratory of Transplantation Immunology, National Research Center for Hematology, Moscow, Russian Federation; Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences
Russian Federation
PhD (Biology), Head, Laboratory of Transplantation Immunology, National Research Center for Hematology, Moscow, Russian Federation; Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences
M. S. Drutskaya
Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow;
Russian Federation
PhD (Biology), Senior Research Associate, Laboratory of Molecular Mechanisms of Immunity
Russian Federation
PhD (Biology), Senior Research Associate, Laboratory of Molecular Mechanisms of Immunity
S. A. Nedospasov
Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow;
Moscow State University
Russian Federation
PhD, MD (Biology), Professor, Head, Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences; Department of Immunology, Faculty of Biology, Moscow State University
Russian Federation
PhD, MD (Biology), Professor, Head, Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences; Department of Immunology, Faculty of Biology, Moscow State University
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For citations:
Bogolyubova A.V., Efimov G.A., Drutskaya M.S., Nedospasov S.A. CANCER IMMUNOTHERAPY BASED ON THE BLOCKADE OF IMMUNE CHECKPOINTS. Medical Immunology (Russia). 2015;17(5):395-406. (In Russ.) https://doi.org/10.15789/1563-0625-2015-5-395-406
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