INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS
https://doi.org/10.15789/1563-0625-2014-4-333-344
Abstract
We have assumed, that serum production of biological markers that are significantly reflecting a risk degree for atherosclerotic process and acute coronary events may be modified by functional polymorphisms of a functional complex of genes that may be involved into inflammatory process and influence mutual regulation of their production. Therefore, we have assayed a number of appropriate gene polymorphisms and assessed frequency distribution for several promoter genotypes and their combinations, e.c., TNF-A863C; TNF-A308G; TNF-A238G; IL1B C-31T; IL1B-C511T; IL4-C590T; IL6-C174G; IL10A-1082G, IL10-А592C genes, regulatory sites of VEGF-А2578С, VEGF+Т936 gene variants. We have also measured serum levels of TNFα, IL-1β, IL-6, IL-8, IL-1 receptor antagonist (IL-1ra), C-reactive protein, soluble CD40 ligand receptor (sCD40L) in the patients with atherosclerosis. In general, it has been shown that contribution of single cytokine genotypes to the association with level of their production is much lower, than odds ratio of changed protein production associated with a compound genotype.
About the Authors
A. V. Shevchenko
Research Institute of Clinical and Experimental Lymphology, Siberian Branch of RAMS, Novosibirsk
Russian Federation
Russian Federation
PhD (Biology), Senior Research Associate, Laboratory of Clinical Immunogenetics, Research Institute of Clinical and Experimental Lymphology, Siberian Branch of RAMS
V. F. Prokofyev
Research Institute of Clinical and Experimental Lymphology, Siberian Branch of RAMS, Novosibirsk
Russian Federation
Russian Federation
PhD (Medicine), Leading Researh Associate, Laboratory of Clinical Immunogenetics, Research Institute of Clinical and Experimental Lymphology Siberian Branch of RAMS
Yu. I. Ragino
Research Institute of Therapy, Siberian Branch of RAMS, Novosibirsk
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Head, Laboratory of Clinical Biochemical and Hormonal Studies of Therapeutic Diseases, Research Institute of Therapy, Siberian Branch of RAMS
A. M. Chernjavski
E.N. Meshalkin State Research Institute of Circulation Pathology, Russian Ministry of Health Care, Novosibirsk
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Head, Center for Surgery of Aorta, Coronary and Peripheral Arteries, E.N.Meshalkin State Research Institute of Circulation Pathology, Russian Ministry of Health Care
M. I. Voevoda
Research Institute of Therapy, Siberian Branch of RAMS, Novosibirsk
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, RAMS Corresponding Member, Director, Research Institute of Therapy,
Siberian Branch of RAMS
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology, Siberian Branch of RAMS, Novosibirsk
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Full Member of RAMS, Director, Research Institute of Clinical and Experimental Lymphology, Siberian Branch of RAMS
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Review
For citations:
Shevchenko A.V., Prokofyev V.F., Ragino Yu.I., Chernjavski A.M., Voevoda M.I., Konenkov V.I. INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS. Medical Immunology (Russia). 2014;16(4):333-344. (In Russ.) https://doi.org/10.15789/1563-0625-2014-4-333-344
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