ВНУТРИВЕННЫЕ ИММУНОГЛОБУЛИНЫ: МЕХАНИЗМЫ ТЕРАПЕВТИЧЕСКИХ ЭФФЕКТОВ
Аннотация
Внутривенные иммуноглобулины (ВВИГ) представляют собой наиболее широко исполь-
зуемые в настоящее время, иммунобиологические лекарства, получаемые из донорской крови. Они содержат антитела, в подавляющем большинстве класса IgG, полученные из пулов плазмы от 3 000 до 15000 доноров (не менее от 1000 доноров, согласно международным требованиям и руководствам) и уже более 40 лет используются при терапии различных заболеваний. Первое время их применение носило сугубо иммунозаместительный характер при первичных иммуннодефицитных состояниях, но в последние годы клинические и экспериментальные данные, показывают эффективность ВВИГ при системных и аутоиммунных заболеваниях, при иммунологическом бесплодии и невынашивании беременности, в транслантологии, гематологии и других областях медицины. Их эффективность связывают с иммуномодулирующими эффектами. Растет количество публикаций посвященной этой теме, понимание механизмов терапевтических эффектов ВВИГ, которые базируются на последних фундаментальных и клинических научных открытиях в этой области. В тоже время много остается не ясным, противоречивым, а некоторые данные носят и вовсе взаимоисключающий характер. Все это обуславливает интерес к данной группе лекарственных средств. Цель данной статьи – обобщить основные известные механизмы лечебных эффектов, результаты последних исследований в данной области, и возможные перспективные направления использования ВВИГ в будущем.
Об авторах
В. А. Лазанович
ГБОУ ВПО «Тихоокеанский государственный медицинский университет» Минздрава России,
г. Владивосток
Россия
Россия
к.м.н., ассистент кафедры клинической лабораторной диагностики, общей и клинической
иммунологии ГБОУ ВПО «Тихоокеанский государственный медицинский университет» Минздрава России
Е. В. Просекова
ГБОУ ВПО «Тихоокеанский государственный медицинский университет» Минздрава России,
г. Владивосток
Россия
Россия
д.м.н., профессор, заведующая кафедрой клинической лабораторной диагностики, общей
и клинической иммунологии ГБОУ ВПО «Тихоокеанский государственный медицинский университет»
Минздрава России
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Для цитирования:
Лазанович В.А., Просекова Е.В. ВНУТРИВЕННЫЕ ИММУНОГЛОБУЛИНЫ: МЕХАНИЗМЫ ТЕРАПЕВТИЧЕСКИХ ЭФФЕКТОВ. Медицинская иммунология. 2014;16(4):311-322. https://doi.org/10.15789/1563-0625-2014-4-311-322
For citation:
Lazanovich V.A., Prosekova E.V. INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS. Medical Immunology (Russia). 2014;16(4):311-322. (In Russ.) https://doi.org/10.15789/1563-0625-2014-4-311-322
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