ВНУТРИВЕННЫЕ ИММУНОГЛОБУЛИНЫ: МЕХАНИЗМЫ ТЕРАПЕВТИЧЕСКИХ ЭФФЕКТОВ
https://doi.org/10.15789/1563-0625-2014-4-311-322
Аннотация
Внутривенные иммуноглобулины (ВВИГ) представляют собой наиболее широко исполь-
зуемые в настоящее время, иммунобиологические лекарства, получаемые из донорской крови. Они содержат антитела, в подавляющем большинстве класса IgG, полученные из пулов плазмы от 3 000 до 15000 доноров (не менее от 1000 доноров, согласно международным требованиям и руководствам) и уже более 40 лет используются при терапии различных заболеваний. Первое время их применение носило сугубо иммунозаместительный характер при первичных иммуннодефицитных состояниях, но в последние годы клинические и экспериментальные данные, показывают эффективность ВВИГ при системных и аутоиммунных заболеваниях, при иммунологическом бесплодии и невынашивании беременности, в транслантологии, гематологии и других областях медицины. Их эффективность связывают с иммуномодулирующими эффектами. Растет количество публикаций посвященной этой теме, понимание механизмов терапевтических эффектов ВВИГ, которые базируются на последних фундаментальных и клинических научных открытиях в этой области. В тоже время много остается не ясным, противоречивым, а некоторые данные носят и вовсе взаимоисключающий характер. Все это обуславливает интерес к данной группе лекарственных средств. Цель данной статьи – обобщить основные известные механизмы лечебных эффектов, результаты последних исследований в данной области, и возможные перспективные направления использования ВВИГ в будущем.
Об авторах
В. А. ЛазановичРоссия
к.м.н., ассистент кафедры клинической лабораторной диагностики, общей и клинической
иммунологии ГБОУ ВПО «Тихоокеанский государственный медицинский университет» Минздрава России
Е. В. Просекова
Россия
д.м.н., профессор, заведующая кафедрой клинической лабораторной диагностики, общей
и клинической иммунологии ГБОУ ВПО «Тихоокеанский государственный медицинский университет»
Минздрава России
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Рецензия
Для цитирования:
Лазанович В.А., Просекова Е.В. ВНУТРИВЕННЫЕ ИММУНОГЛОБУЛИНЫ: МЕХАНИЗМЫ ТЕРАПЕВТИЧЕСКИХ ЭФФЕКТОВ. Медицинская иммунология. 2014;16(4):311-322. https://doi.org/10.15789/1563-0625-2014-4-311-322
For citation:
Lazanovich V.A., Prosekova E.V. INTRAVENOUS IMMUNOGLOBULINS: MECHANISMS OF THERAPEUTIC EFFECTS. Medical Immunology (Russia). 2014;16(4):311-322. (In Russ.) https://doi.org/10.15789/1563-0625-2014-4-311-322