CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME
https://doi.org/10.15789/1563-0625-2013-4-369-374
Abstract
Abstract. The aim of this study was to investigate some characteristics of neutrophils and monocytes in patients with acute leukemia, depending on presence of an infectious syndrome, as based on studying of CD16, CD64, HLA-DR receptors, along with assaying myeloperoxidase (MPO) and functional activity of the cells. Infectious syndrome in acute leukemia patients was accompanied by changes in antibody-dependent cytotoxicity against neutrophils (decreased CD16 and increase in CD64 expression), lower phagocytic capacity of the cells, and myeloperoxidase deficiency of neutrophils and monocytes. In patients with inflammatory manifestations of infectious syndrome (i.e., acute tonsillitis, bronchitis, pneumonia, etc.), the signs of neutrophilic insussiciency were more pronounced, i.e., CD16+ neutrophils comprised 24.36±7.43%, as compared with 74.21±5.43% in controls, p < 0.001; MPO positivity was detected in 29.15±12.6% of the cells against 96.1±1.94% in controls, p < 0.01; MPO expression: 5.34±3.07 MFI, with 32.9±10.76 in controls, p < 0,05. These data suggest significant disturbances of anti-infectious elimination mechanisms.
About the Authors
S. V. Plotnikova
Bashkir State Medical University, Russian Ministry of Health Care, Ufa
Russian Federation
Russian Federation
PhD candidate, Department of Therapy and General Practice with the Course of Geriatrics, Institute of Postgraduate Education
450075, Prospect October, 93/3 apt 4. Phone: 7 (347) 233-58-42
L. F. Aznabaeva
Bashkir State Medical University, Russian Ministry of Health Care, Ufa
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Department of Otorhinolaryngology, Institute of Postgraduate Education
G. Sh. Safuanova
Bashkir State Medical University, Russian Ministry of Health Care, Ufa
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Department of Therapy and General Practice with the Course of Geriatrics, Institute of Postgraduate Education
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Review
For citations:
Plotnikova S.V., Aznabaeva L.F., Safuanova G.Sh. CHARACTERISTICS OF PHAGOCYTIC CELLS IN PATIENTS WITH ACUTE LEUKEMIA WITH AN INFECTIOUS SYNDROME. Medical Immunology (Russia). 2013;15(4):369-374. (In Russ.) https://doi.org/10.15789/1563-0625-2013-4-369-374
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