CHANGING EXPRESSION OF SOME MOLECULES ON THE SURFACE OF HUMAN BLOOD T-LYMPHOCYTES UPON UV-IRRADIATION OF CELL SUSPENSIONS
https://doi.org/10.15789/1563-0625-2013-4-361-368
Abstract
Abstract. We have studied effects of UV irradiation (240-390 nm) at a dose range of 151 to 1359 J/m2 upon expression levels of different surface markers (CD2, CD11a, CD3, CD4, CD8) of human blood T lymphocytes by means of laser flow cytofluorimetry. It is revealed that UV-irradiation at the doses of 151 to 906 J/m2 caused increased expression of CD3, CD4, CD8 membrane markers of the T-lymphocytes. Meanwhile, it was shown that expression levels of CD2 and CD11a adhesion molecules on T-lymphocytes after exposure to UVirradiation (151 to 906 J/m2) remained similar to those for intact cells. UV-irradiation at a dose of 1359 J/ m2 was shown to reduce expression of CD2, CD11a and CD3 markers, along with increased expression level of CD4 and CD8 co-receptor molecules at the T-lymphocytes.
About the Authors
V. G. Artuykhov
Voronezh State University, Voronezh
Russian Federation
Russian Federation
PhD, MD (Biology), Professor, Department of Biophysics and Biotechnology
O. V. Putintseva
Voronezh State University, Voronezh
Russian Federation
Russian Federation
PhD, MD (Biology), Professor, Department of Biophysics and Biotechnology
S. M. Dubova
Voronezh State University, Voronezh
Russian Federation
Russian Federation
PhD (Biology), Department of Biophysics and Biotechnology
V. A. Bragina
Voronezh State Medical Academy of N.N. Burdenko of Russian Federation Health Ministry, Voronezh
Russian Federation
Russian Federation
PhD (Biology), Department of Pathological Physiology
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Review
For citations:
Artuykhov V.G., Putintseva O.V., Dubova S.M., Bragina V.A. CHANGING EXPRESSION OF SOME MOLECULES ON THE SURFACE OF HUMAN BLOOD T-LYMPHOCYTES UPON UV-IRRADIATION OF CELL SUSPENSIONS. Medical Immunology (Russia). 2013;15(4):361-368. (In Russ.) https://doi.org/10.15789/1563-0625-2013-4-361-368
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