CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
https://doi.org/10.15789/1563-0625-2011-2-3-197-204
Abstract
Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204
About the Authors
A. V. Sosnina
НИИ молекулярной биологии и биофизики СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
A. I. Autenshlyus
НИИ молекулярной биологии и биофизики СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
N. V. Velikaya
Russian Federation
N. A. Varaksin
ЗАО «Вектор-Бест», г. Новосибирск
Russian Federation
Russian Federation
M. Yu. Rukhavishnikov
ЗАО «Вектор-Бест», г. Новосибирск
Russian Federation
Russian Federation
E. S. Mikhailova
НИИ молекулярной биологии и биофизики СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
D. V. Morozov
НИИ молекулярной биологии и биофизики СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
S. A. Fursov
Новосибирский областной онкологический диспансер, г. Новосибирск
Russian Federation
Russian Federation
N. V. Agarina
Новосибирский областной онкологический диспансер, г. Новосибирск
Russian Federation
Russian Federation
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Review
For citations:
Sosnina A.V., Autenshlyus A.I., Velikaya N.V., Varaksin N.A., Rukhavishnikov M.Yu., Mikhailova E.S., Morozov D.V., Fursov S.A., Agarina N.V. CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS. Medical Immunology (Russia). 2011;13(2-3):197-204. (In Russ.) https://doi.org/10.15789/1563-0625-2011-2-3-197-204
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