ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS
https://doi.org/10.15789/1563-0625-2010-6-537-546
Abstract
Antibodies to the cytoplasm of neutrophils (p-ANCA) are detectable in 67% of patients with ulcerative colitis (UC). We have revealed typical clinical features of the patients with diagnostic p-ANCA titer, i.e., longer disease duration, prolonged fevers, and increased stool frequency. Moreover, thrombocytosis, leukocytosis and hypoalbuminemia are more common in this group. By endoscopic examination, mucosal ulcers of the colon are significantly more frequent in this group of patients. We have also noted higher rates of severe and relapsing cases among p-ANCA-positive patients. The data obtained allow us to suggest that the diagnostic titers of p-ANCA are predictive for unfavorable prognosis in UC.
About the Authors
A. G. Kharitonov
СПб МАПО, кафедра гастроэнтерологии, Санкт-Петербург
Russian Federation
Russian Federation
E. A. Kondrashina
СПб МАПО, кафедра гастроэнтерологии, Санкт-Петербург
Russian Federation
Russian Federation
A. Yu. Baranovsky
СПб МАПО, кафедра гастроэнтерологии, Санкт-Петербург
Russian Federation
Russian Federation
T. V. Bulgakova
СПбГМУ им. акад. И.П. Павлова, Научно-методический центр по молекулярной медицине, Лаборатория
диагностики аутоиммунных заболеваний, Санкт-Петербург
Russian Federation
Russian Federation
S. V. Lapin
СПбГМУ им. акад. И.П. Павлова, Научно-методический центр по молекулярной медицине, Лаборатория
диагностики аутоиммунных заболеваний, Санкт-Петербург
Russian Federation
Russian Federation
Areg A. Totolian
St. Petersburg Pasteur Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
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Review
For citations:
Kharitonov A.G., Kondrashina E.A., Baranovsky A.Yu., Bulgakova T.V., Lapin S.V., Totolian A.A. ANTIBODIES TO THE CYTOPLASM OF NEUTROPHILS: A MARKER OF UNFAVORABLE CLINICAL COURSE IN NON-SPECIFIC ULCERATIVE COLITIS. Medical Immunology (Russia). 2010;12(6):537-546. (In Russ.) https://doi.org/10.15789/1563-0625-2010-6-537-546
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