IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN
https://doi.org/10.15789/1563-0625-2010-6-511-520
Abstract
The study deals with evaluation of immune parameters in healthy fertile women (n = 48) versus female patients with infertility of unknown origin (n = 386). A comparative analysis has shown similar patterns of immune dysfunction in women with primary infertility (n = 179) and recurrent spontaneous abortion (n = 207). The most common markers of immune dysfunction include decreased production of blocking antibodies (86.5% of cases), low proliferative response to paternal alloantigens in mixed leukocyte reaction (MLR) shown in 51.5% of cases, and increased number of activated CD56+CD16+NK-cells (42.0%). Decreased production of MLR-blocking antibodies may be caused by low lymphocyte response, due to the partner's HLA-similarity, or by predominance of Th1/proinflammatory cytokines and low contents of circulating regulatory CD4+CD25+T-cells. The study results demonstrate that development of primary infertility and recurrent spontaneous abortions is associated with a uniform set of immune disorders, thus probably reflecting a failure of suppressor rearrangement within immune system during periovulatory period of menstrual cycle.
About the Authors
N. A. Khonina
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
M. A. Tikhonova
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
I. B. Dzutzeva
МЦ планирования семьи и репродукции, г. Новосибирск
Russian Federation
Russian Federation
N. M. Pasman
Новосибирский государственный университет, г. Новосибирск
Russian Federation
Russian Federation
A. A. Ostanin
Russian Federation
Competing Interests: НИИ клинической иммунологии СО РАМН, г. Новосибирск
E. R. Chernykh
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
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Review
For citations:
Khonina N.A., Tikhonova M.A., Dzutzeva I.B., Pasman N.M., Ostanin A.A., Chernykh E.R. IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN. Medical Immunology (Russia). 2010;12(6):511-520. (In Russ.) https://doi.org/10.15789/1563-0625-2010-6-511-520
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