PROTIA™ Allergy-Q Atopy® test system for the allergy diagnostics in psoriasis

Recently, the relationship between autoimmune diseases and atopy is one of the important areas of scientific studies. There is evidence of a relationship between atopy and psoriasis (PS). Thus, the study of sIgE concentration to 44 causally significant allergens was performed using PROTIA™ Allergy-Q test system (atopic panel) by the immunoblotting method being of particular diagnostic relevance. Objective of our study was to conduct a comparative analysis of the presence of allergen-specific IgEs to the common food, fungal, pollen, household and epidermal allergens in the blood serum samples from patients with PS using the immunoblotting method (Allergy-Q® system). The study included patients with PS (group 1, n = 51). The comparison group was patients with atopic dermatitis (AD, group 2, n = 20). The average age of patients in group 1 was 40.0±1.8 years, in group 2 – 25.0±2.0 years. The control group consisted of practically healthy individuals matched by gender and age with patients (group 3, n = 19). All patients underwent a specific allergological examination, including medical history of allergy, determination of total immunoglobulin E (IgE) level in the blood serum and the sensitization spectrum based on measurable concentration of allergen-specific IgE (sIgE) to 44 most common allergens in blood serum by immunoblotting technique using the Allergy-Q® test system (atopic panel, Korea). Statistical processing of the obtained results was carried out using the application program “Statistica 8.0”. Sensitization of atopic origin was noted in 35.3% (n = 18) of patients with PS and in 90% (n = 18) of cases with atopic dermatitis. In the group of patients with AD, the most significant food allergen was peach compared to the group of patients with PS and the control. Sensitization to potato, rice, peanut, peach was significantly higher among patients with PS compared to the control. In the group of patients with AD, sensitization to ragweed, wormwood, alder-birch mixture pollen was statistically significantly higher if compared to the control group. In PS, the highest frequency of sensitization to ragweed pollen was found in comparison with the group of patients with AD and control group. In the group of patients with PS, a statistically significant increase in the frequency of sensitization to staphylococcal enterotoxin B, Candida albicans was noted when compared with the group of patients with AD and the control persons. An increased frequency of sensitization to cat and dog epithelium was noted in the groups of patients with PS and AD in comparison with the control group. Thus, our study substantiates the need for specific allergological examination of patients with PS in order to establish causative allergens, especially in the cases of a severe course of the disease.

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