ГАММА-ДЕЛЬТА (γδ) T-КЛЕТКИ: ПРОИСХОЖДЕНИЕ, ФЕНОТИП, ФУНКЦИИ

Резюме

Важнейшей функцией γδТ-клеток является контроль за реакциями врожденного и адаптивного иммунитета. Эти клетки также участвуют в противобактериальном, противовирусном, противоопухолевом иммунитете, регулируют воспаление, определяют гомеостаз барьерных тканей, регулируют взаимодействие клеток в зоне маточно-плацентарного контакта и осуществляют надзор за течением беременности, участвуют в патогенезе аутоиммунных заболеваний, участвуют в ранозаживлении, поддерживают целостность эпителия. За последние годы в литературе появилось большое количество данных о многообразии субпопуляций γδT-клеток, порой противоположных, или даже антагонистических, роли этих субпопуляций в физиологических и патологических процессах. Поэтому целью настоящего обзора явилась систематизация данных о биологии γδT-клеток, их происхождении, фенотипе, функциях и способах применения в клинике. В обзоре изложены современные представления о происхождении γδТ-клеток, стадиях их внутритимической дифференцировки, возможностях внетимической трансдифференцировки одних субпопуляций в другие. В обзоре приведена современная классификация субпопуляций γδТ-клеток человека, основанная на экспрессии γ- и δ цепей Т-клеточного рецептора, описаны фенотип и свойства наиболее распространенных популяций Vδ1, Vδ2, Vδ3 Т-клеток. Приведена классификация γδТ-клеток человека, основанная на продукции ими цитокинов и экспрессии внутриклеточных мессенджеров, подробно описаны свойства и функции наиболее изученных субпопуляций: γδT1, γδT17, γδNKT, γδTreg, γδT_APC, γδTfh. В обзоре особое внимание уделяется фенотипу различных популяций, секреции ими цитокинов, приводятся данные об экспрессии поверхностных рецепторов γδТ-клеток человека и их функциях. В частности, рассмотрены особенности строения и лиганды γδТ-клеточного рецептора, а также рецепторы, контролирующие их активность (LIRB1/ILT2, KIR2DL1, KIR2DL2/3, KIR2DL4, KIR2DS1, KIR2DS2, KIR3DL2, KLRD1, NKG2A, NKG2C, NKG2D, NKG2F, NKp30, NKp44, NKp46, KLRC3, DNAM1, KLRG1/MAFA, FcγRIII, BTLA, PD1, TIGIT, VISTA, LAG3, TIM3, CTLA-4, 2B4, NK1 (NK28), KLRB1, TLR1, TLR2, TLR3, TLR5, TLR6, TLR7, TLR8), цитотоксичность в отношении клеток-мишеней, хемокиновые CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR9, CCR10, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, цитокиновые и адгезионные рецепторы. В обзоре приведена информация об участии субпопуляций γδТ-клеток человека в различных физиологических и патологических процессах, отмечена их неоднозначная роль в надзоре за опухолевым ростом. На основании описанных данных приводятся сведения о возможных перспективах применения γδТ-клеток в терапии некоторых заболеваний.

1. Agrati C., Alonzi T., De Santis R., Castilletti C., Abbate I., Capobianchi M.R., D'Offizi G., Siepi F., Fimia G.M., Tripodi M.,Poccia F. Activation of Vgamma9Vdelta2 T cells by non-peptidic antigens induces the inhibition of subgenomic HCV replication. Int Immunol, 2006, Vol.18, no 1, pp. 11-8. 10.1093/intimm/dxh337

2. Alexander A.A., Maniar A., Cummings J.S., Hebbeler A.M., Schulze D.H., Gastman B.R., Pauza C.D., Strome S.E.,Chapoval A.I. Isopentenyl pyrophosphate-activated CD56+ gammadelta T lymphocytes display potent antitumor activity toward human squamous cell carcinoma. Clin Cancer Res, 2008, Vol.14, no 13, pp. 4232-40. 10.1158/1078-0432.CCR-07-4912

3. Anvari S., Watkin L., Rajapakshe K., Hassan O., Schuster K., Coarfa C.,Davis C.M. Memory and naive gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy. Clin Immunol, 2021, Vol.230, no, pp. 108820. 10.1016/j.clim.2021.108820

4. Autran B., Triebel F., Katlama C., Rozenbaum W., Hercend T.,Debre P. T cell receptor gamma/delta+ lymphocyte subsets during HIV infection. Clin Exp Immunol, 1989, Vol.75, no 2, pp. 206-10. https://www.ncbi.nlm.nih.gov/pubmed/2522839

5. Bank I. The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases. Cells, 2020, Vol.9, no 2. 10.3390/cells9020462

6. Bansal R.R., Mackay C.R., Moser B.,Eberl M. IL-21 enhances the potential of human gammadelta T cells to provide B-cell help. Eur J Immunol, 2012, Vol.42, no 1, pp. 110-9. 10.1002/eji.201142017

7. Barisa M., Kramer A.M., Majani Y., Moulding D., Saraiva L., Bajaj-Elliott M., Anderson J.,Gustafsson K. E. coli promotes human Vgamma9Vdelta2 T cell transition from cytokine-producing bactericidal effectors to professional phagocytic killers in a TCR-dependent manner. Sci Rep, 2017, Vol.7, no 1, pp. 2805. 10.1038/s41598-017-02886-8

8. Barjon C., Michaud H.A., Fages A., Dejou C., Zampieri A., They L., Gennetier A., Sanchez F., Gros L., Eliaou J.F., Bonnefoy N.,Lafont V. IL-21 promotes the development of a CD73-positive Vgamma9Vdelta2 T cell regulatory population. Oncoimmunology, 2017, Vol.7, no 1, pp. e1379642. 10.1080/2162402X.2017.1379642

9. Bennett S.R., Carbone F.R., Karamalis F., Flavell R.A., Miller J.F.,Heath W.R. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature, 1998, Vol.393, no 6684, pp. 478-80. 10.1038/30996

10. Benveniste P.M., Roy S., Nakatsugawa M., Chen E.L.Y., Nguyen L., Millar D.G., Ohashi P.S., Hirano N., Adams E.J.,Zuniga-Pflucker J.C. Generation and molecular recognition of melanoma-associated antigen-specific human gammadelta T cells. Sci Immunol, 2018, Vol.3, no 30. 10.1126/sciimmunol.aav4036

11. Birkinshaw R.W., Pellicci D.G., Cheng T.Y., Keller A.N., Sandoval-Romero M., Gras S., de Jong A., Uldrich A.P., Moody D.B., Godfrey D.I.,Rossjohn J. alphabeta T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat Immunol, 2015, Vol.16, no 3, pp. 258-66. 10.1038/ni.3098

12. Boehme L., Roels J.,Taghon T. Development of gammadelta T cells in the thymus - A human perspective. Semin Immunol, 2022, Vol.61-64, no, pp. 101662. 10.1016/j.smim.2022.101662

13. Bonneville M., O'Brien R.L.,Born W.K. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol, 2010, Vol.10, no 7, pp. 467-78. 10.1038/nri2781

14. Brandes M., Willimann K., Bioley G., Levy N., Eberl M., Luo M., Tampe R., Levy F., Romero P.,Moser B. Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses. Proc Natl Acad Sci U S A, 2009, Vol.106, no 7, pp. 2307-12. 10.1073/pnas.0810059106

15. Brandes M., Willimann K., Lang A.B., Nam K.H., Jin C., Brenner M.B., Morita C.T.,Moser B. Flexible migration program regulates gamma delta T-cell involvement in humoral immunity. Blood, 2003, Vol.102, no 10, pp. 3693-701. 10.1182/blood-2003-04-1016

16. Brandes M., Willimann K.,Moser B. Professional antigen-presentation function by human gammadelta T Cells. Science, 2005, Vol.309, no 5732, pp. 264-8. 10.1126/science.1110267

17. Buus T.B., Odum N., Geisler C.,Lauritsen J.P.H. Three distinct developmental pathways for adaptive and two IFN-gamma-producing gammadelta T subsets in adult thymus. Nat Commun, 2017, Vol.8, no 1, pp. 1911. 10.1038/s41467-017-01963-w

18. Caccamo N., La Mendola C., Orlando V., Meraviglia S., Todaro M., Stassi G., Sireci G., Fournie J.J.,Dieli F. Differentiation, phenotype, and function of interleukin-17-producing human Vgamma9Vdelta2 T cells. Blood, 2011, Vol.118, no 1, pp. 129-38. 10.1182/blood-2011-01-331298

19. Caccamo N., Meraviglia S., Ferlazzo V., Angelini D., Borsellino G., Poccia F., Battistini L., Dieli F.,Salerno A. Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vgamma9Vdelta2 naive, memory and effector T cell subsets. Eur J Immunol, 2005, Vol.35, no 6, pp. 1764-72. 10.1002/eji.200525983

20. Caccamo N., Todaro M., La Manna M.P., Sireci G., Stassi G.,Dieli F. IL-21 regulates the differentiation of a human gammadelta T cell subset equipped with B cell helper activity. PLoS One, 2012, Vol.7, no 7, pp. e41940. 10.1371/journal.pone.0041940

21. Caccamo N., Todaro M., Sireci G., Meraviglia S., Stassi G.,Dieli F. Mechanisms underlying lineage commitment and plasticity of human gammadelta T cells. Cell Mol Immunol, 2013, Vol.10, no 1, pp. 30-4. 10.1038/cmi.2012.42

22. Cai Y., Xue F., Quan C., Qu M., Liu N., Zhang Y., Fleming C., Hu X., Zhang H.G., Weichselbaum R., Fu Y.X., Tieri D., Rouchka E.C., Zheng J.,Yan J. A Critical Role of the IL-1beta-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis. J Invest Dermatol, 2019, Vol.139, no 1, pp. 146-156. 10.1016/j.jid.2018.07.025

23. Carman C.V.,Springer T.A. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J Cell Biol, 2004, Vol.167, no 2, pp. 377-88. 10.1083/jcb.200404129

24. Cartwright J.E.,Balarajah G. Trophoblast interactions with endothelial cells are increased by interleukin-1beta and tumour necrosis factor alpha and involve vascular cell adhesion molecule-1 and alpha4beta1. Exp Cell Res, 2005, Vol.304, no 1, pp. 328-36. 10.1016/j.yexcr.2004.11.013

25. Casetti R., Agrati C., Wallace M., Sacchi A., Martini F., Martino A., Rinaldi A.,Malkovsky M. Cutting edge: TGF-beta1 and IL-15 Induce FOXP3+ gammadelta regulatory T cells in the presence of antigen stimulation. J Immunol, 2009, Vol.183, no 6, pp. 3574-7. 10.4049/jimmunol.0901334

26. Castella B., Foglietta M., Sciancalepore P., Rigoni M., Coscia M., Griggio V., Vitale C., Ferracini R., Saraci E., Omede P., Riganti C., Palumbo A., Boccadoro M.,Massaia M. Anergic bone marrow Vgamma9Vdelta2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma. Oncoimmunology, 2015, Vol.4, no 11, pp. e1047580. 10.1080/2162402X.2015.1047580

27. Chabab G., Barjon C., Abdellaoui N., Salvador-Prince L., Dejou C., Michaud H.A., Boissiere-Michot F., Lopez-Crapez E., Jacot W., Pourquier D., Bonnefoy N.,Lafont V. Identification of a regulatory Vdelta1 gamma delta T cell subpopulation expressing CD73 in human breast cancer. J Leukoc Biol, 2020, Vol.107, no 6, pp. 1057-1067. 10.1002/JLB.3MA0420-278RR

28. Chabab G., Barjon C., Bonnefoy N.,Lafont V. Pro-tumor gammadelta T Cells in Human Cancer: Polarization, Mechanisms of Action, and Implications for Therapy. Front Immunol, 2020, Vol.11, no, pp. 2186. 10.3389/fimmu.2020.02186

29. Chan K.F., Duarte J.D.G., Ostrouska S.,Behren A. gammadelta T Cells in the Tumor Microenvironment-Interactions With Other Immune Cells. Front Immunol, 2022, Vol.13, no, pp. 894315. 10.3389/fimmu.2022.894315

30. Chen W. TGF-beta Regulation of T Cells. Annu Rev Immunol, 2023, Vol.41, no 1, pp. 483-512. 10.1146/annurev-immunol-101921-045939

31. Chien Y.H., Meyer C.,Bonneville M. gammadelta T cells: first line of defense and beyond. Annu Rev Immunol, 2014, Vol.32, no, pp. 121-55. 10.1146/annurev-immunol-032713-120216

32. Christopoulos P., Dopfer E.P., Malkovsky M., Esser P.R., Schaefer H.E., Marx A., Kock S., Rupp N., Lorenz M.R., Schwarz K., Harder J., Martin S.F., Werner M., Bogdan C., Schamel W.W.,Fisch P. A novel thymoma-associated immunodeficiency with increased naive T cells and reduced CD247 expression. J Immunol, 2015, Vol.194, no 7, pp. 3045-53. 10.4049/jimmunol.1402805

33. Cibrian D.,Sanchez-Madrid F. CD69: from activation marker to metabolic gatekeeper. Eur J Immunol, 2017, Vol.47, no 6, pp. 946-953. 10.1002/eji.201646837

34. Ciccone E., Viale O., Pende D., Malnati M., Battista Ferrara G., Barocci S., Moretta A.,Moretta L. Specificity of human T lymphocytes expressing a gamma/delta T cell antigen receptor. Recognition of a polymorphic determinant of HLA class I molecules by a gamma/delta clone. Eur J Immunol, 1989, Vol.19, no 7, pp. 1267-71. 10.1002/eji.1830190718

35. Cipriani B., Borsellino G., Poccia F., Placido R., Tramonti D., Bach S., Battistini L.,Brosnan C.F. Activation of C-C beta-chemokines in human peripheral blood gammadelta T cells by isopentenyl pyrophosphate and regulation by cytokines. Blood, 2000, Vol.95, no 1, pp. 39-47. 10.1182/blood.V95.1.39

36. Coffelt S.B., Kersten K., Doornebal C.W., Weiden J., Vrijland K., Hau C.S., Verstegen N.J.M., Ciampricotti M., Hawinkels L., Jonkers J.,de Visser K.E. IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Nature, 2015, Vol.522, no 7556, pp. 345-348. 10.1038/nature14282

37. Cox S.T., Haver D.S., Patterson W., Cambridge C.A., Turner T.R., Danby R.D.,Hernandez D. Characterisation of RAET1E/ULBP4 exon 4 and 3' untranslated region genetic architecture reveals further diversity and allelic polymorphism. HLA, 2024, Vol.103, no 4, pp. e15457. 10.1111/tan.15457

38. Dai Y., Chen H., Mo C., Cui L.,He W. Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human gammadelta T cells to induce innate anti-tumor/virus immunity. J Biol Chem, 2012, Vol.287, no 20, pp. 16812-9. 10.1074/jbc.M111.327650

39. Daley D., Zambirinis C.P., Seifert L., Akkad N., Mohan N., Werba G., Barilla R., Torres-Hernandez A., Hundeyin M., Mani V.R.K., Avanzi A., Tippens D., Narayanan R., Jang J.E., Newman E., Pillarisetty V.G., Dustin M.L., Bar-Sagi D., Hajdu C.,Miller G. gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation. Cell, 2016, Vol.166, no 6, pp. 1485-1499 e15. 10.1016/j.cell.2016.07.046

40. Davey M.S., Willcox C.R., Joyce S.P., Ladell K., Kasatskaya S.A., McLaren J.E., Hunter S., Salim M., Mohammed F., Price D.A., Chudakov D.M.,Willcox B.E. Clonal selection in the human Vdelta1 T cell repertoire indicates gammadelta TCR-dependent adaptive immune surveillance. Nat Commun, 2017, Vol.8, no, pp. 14760. 10.1038/ncomms14760

41. de Vries N.L., van de Haar J., Veninga V., Chalabi M., Ijsselsteijn M.E., van der Ploeg M., van den Bulk J., Ruano D., van den Berg J.G., Haanen J.B., Zeverijn L.J., Geurts B.S., de Wit G.F., Battaglia T.W., Gelderblom H., Verheul H.M.W., Schumacher T.N., Wessels L.F.A., Koning F., de Miranda N.,Voest E.E. gammadelta T cells are effectors of immunotherapy in cancers with HLA class I defects. Nature, 2023, Vol.613, no 7945, pp. 743-750. 10.1038/s41586-022-05593-1

42. DeBarros A., Chaves-Ferreira M., d'Orey F., Ribot J.C.,Silva-Santos B. CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human gammadelta peripheral blood lymphocytes. Eur J Immunol, 2011, Vol.41, no 1, pp. 195-201. 10.1002/eji.201040905

43. Dechanet J., Merville P., Lim A., Retiere C., Pitard V., Lafarge X., Michelson S., Meric C., Hallet M.M., Kourilsky P., Potaux L., Bonneville M.,Moreau J.F. Implication of gammadelta T cells in the human immune response to cytomegalovirus. J Clin Invest, 1999, Vol.103, no 10, pp. 1437-49. 10.1172/JCI5409

44. Deetz C.O., Hebbeler A.M., Propp N.A., Cairo C., Tikhonov I.,Pauza C.D. Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys. Infect Immun, 2006, Vol.74, no 8, pp. 4505-11. 10.1128/IAI.00088-06

45. Degli-Esposti M.A., Smolak P.J., Walczak H., Waugh J., Huang C.P., DuBose R.F., Goodwin R.G.,Smith C.A. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J Exp Med, 1997, Vol.186, no 7, pp. 1165-70. 10.1084/jem.186.7.1165

46. Del Porto P., D'Amato M., Fiorillo M.T., Tuosto L., Piccolella E.,Sorrentino R. Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone. J Immunol, 1994, Vol.153, no 7, pp. 3093-100.

47. Deng S., Jiang Y., Luo L., Tang H., Hu X., Wu C., Tang J., Ge H., Gong X., Cai R., Wang G., Li X.,Feng J. C5a enhances inflammation and chemotaxis of gammadelta T cells in malignant pleural effusion. Int Immunopharmacol, 2024, Vol.127, no, pp. 111332. 10.1016/j.intimp.2023.111332

48. Deseke M.,Prinz I. Ligand recognition by the gammadelta TCR and discrimination between homeostasis and stress conditions. Cell Mol Immunol, 2020, Vol.17, no 9, pp. 914-924. 10.1038/s41423-020-0503-y

49. Deseke M., Rampoldi F., Sandrock I., Borst E., Boning H., Ssebyatika G.L., Jurgens C., Pluckebaum N., Beck M., Hassan A., Tan L., Demera A., Janssen A., Steinberger P., Koenecke C., Viejo-Borbolla A., Messerle M., Krey T.,Prinz I. A CMV-induced adaptive human Vdelta1+ gammadelta T cell clone recognizes HLA-DR. J Exp Med, 2022, Vol.219, no 9. 10.1084/jem.20212525

50. Deusch K., Luling F., Reich K., Classen M., Wagner H.,Pfeffer K. A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur J Immunol, 1991, Vol.21, no 4, pp. 1053-9. 10.1002/eji.1830210429

51. Di Lorenzo B., Ravens S.,Silva-Santos B. High-throughput analysis of the human thymic Vdelta1(+) T cell receptor repertoire. Sci Data, 2019, Vol.6, no 1, pp. 115. 10.1038/s41597-019-0118-2

52. Dieli F., Poccia F., Lipp M., Sireci G., Caccamo N., Di Sano C.,Salerno A. Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites. J Exp Med, 2003, Vol.198, no 3, pp. 391-7. 10.1084/jem.20030235

53. Dieli F., Troye-Blomberg M., Ivanyi J., Fournie J.J., Krensky A.M., Bonneville M., Peyrat M.A., Caccamo N., Sireci G.,Salerno A. Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes. J Infect Dis, 2001, Vol.184, no 8, pp. 1082-5. 10.1086/323600

54. Dimova T., Brouwer M., Gosselin F., Tassignon J., Leo O., Donner C., Marchant A.,Vermijlen D. Effector Vgamma9Vdelta2 T cells dominate the human fetal gammadelta T-cell repertoire. Proc Natl Acad Sci U S A, 2015, Vol.112, no 6, pp. E556-65. 10.1073/pnas.1412058112

55. Dondero A., Pastorino F., Della Chiesa M., Corrias M.V., Morandi F., Pistoia V., Olive D., Bellora F., Locatelli F., Castellano A., Moretta L., Moretta A., Bottino C.,Castriconi R. PD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance. Oncoimmunology, 2016, Vol.5, no 1, pp. e1064578. 10.1080/2162402X.2015.1064578

56. Du Y., Peng Q., Cheng D., Pan T., Sun W., Wang H., Ma X., He R., Zhang H., Cui Z., Feng X., Liu Z., Zhao T., Hu W., Shen L., Jiang W., Gao N., Martin B.N., Zhang C.J., Zhang Z.,Wang C. Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing gammadelta T cells. Nat Commun, 2022, Vol.13, no 1, pp. 231. 10.1038/s41467-021-27936-8

57. Dudal S., Turriere C., Bessoles S., Fontes P., Sanchez F., Liautard J., Liautard J.P.,Lafont V. Release of LL-37 by activated human Vgamma9Vdelta2 T cells: a microbicidal weapon against Brucella suis. J Immunol, 2006, Vol.177, no 8, pp. 5533-9. 10.4049/jimmunol.177.8.5533

58. Edwards S.C., Hedley A., Hoevenaar W.H.M., Wiesheu R., Glauner T., Kilbey A., Shaw R., Boufea K., Batada N., Hatano S., Yoshikai Y., Blyth K., Miller C., Kirschner K.,Coffelt S.B. PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A-producing gammadelta T cells. J Exp Med, 2023, Vol.220, no 2. 10.1084/jem.20211431

59. Fenoglio D., Poggi A., Catellani S., Battaglia F., Ferrera A., Setti M., Murdaca G.,Zocchi M.R. Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. Blood, 2009, Vol.113, no 26, pp. 6611-8. 10.1182/blood-2009-01-198028

60. Field K.R., Wragg K.M., Kent S.J., Lee W.S.,Juno J.A. gammadelta T cells mediate robust anti-HIV functions during antiretroviral therapy regardless of immune checkpoint expression. Clin Transl Immunology, 2024, Vol.13, no 2, pp. e1486. 10.1002/cti2.1486

61. Fischer M.A., Golovchenko N.B.,Edelblum K.L. gammadelta T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces. Immunol Rev, 2020, Vol.298, no 1, pp. 165-180. 10.1111/imr.12915

62. Flajnik M.F. A cold-blooded view of adaptive immunity. Nat Rev Immunol, 2018, Vol.18, no 7, pp. 438-453. 10.1038/s41577-018-0003-9

63. Flemming A. Dectin-1 on colonic gammadelta T cells mediates vulnerability to psychosocial stress. Nat Rev Immunol, 2023, Vol.23, no 5, pp. 271. 10.1038/s41577-023-00876-8

64. Fowler D.W., Copier J., Wilson N., Dalgleish A.G.,Bodman-Smith M.D. Mycobacteria activate gammadelta T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy. Cancer Immunol Immunother, 2012, Vol.61, no 4, pp. 535-47. 10.1007/s00262-011-1121-4

65. Frascoli M., Ferraj E., Miu B., Malin J., Spidale N.A., Cowan J., Shissler S.C., Brink R., Xu Y., Cyster J.G., Bhandoola A., Kang J.,Reboldi A. Skin gammadelta T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol. Immunity, 2023, Vol.56, no 3, pp. 562-575 e6. 10.1016/j.immuni.2023.01.025

66. Fuertes M.B., Domaica C.I.,Zwirner N.W. Leveraging NKG2D Ligands in Immuno-Oncology. Front Immunol, 2021, Vol.12, no, pp. 713158. 10.3389/fimmu.2021.713158

67. Ganapathy T., Radhakrishnan R., Sakshi S.,Martin S. CAR gammadelta T cells for cancer immunotherapy. Is the field more yellow than green? Cancer Immunol Immunother, 2023, Vol.72, no 2, pp. 277-286. 10.1007/s00262-022-03260-y

68. Gaur P., Misra R.,Aggarwal A. Natural killer cell and gamma delta T cell alterations in enthesitis related arthritis category of juvenile idiopathic arthritis. Clin Immunol, 2015, Vol.161, no 2, pp. 163-9. 10.1016/j.clim.2015.07.012

69. Gertner-Dardenne J., Fauriat C., Orlanducci F., Thibult M.L., Pastor S., Fitzgibbon J., Bouabdallah R., Xerri L.,Olive D. The co-receptor BTLA negatively regulates human Vgamma9Vdelta2 T-cell proliferation: a potential way of immune escape for lymphoma cells. Blood, 2013, Vol.122, no 6, pp. 922-31. 10.1182/blood-2012-11-464685

70. Girard P., Charles J., Cluzel C., Degeorges E., Manches O., Plumas J., De Fraipont F., Leccia M.T., Mouret S., Chaperot L.,Aspord C. The features of circulating and tumor-infiltrating gammadelta T cells in melanoma patients display critical perturbations with prognostic impact on clinical outcome. Oncoimmunology, 2019, Vol.8, no 8, pp. 1601483. 10.1080/2162402X.2019.1601483

71. Glatzel A., Wesch D., Schiemann F., Brandt E., Janssen O.,Kabelitz D. Patterns of chemokine receptor expression on peripheral blood gamma delta T lymphocytes: strong expression of CCR5 is a selective feature of V delta 2/V gamma 9 gamma delta T cells. J Immunol, 2002, Vol.168, no 10, pp. 4920-9. 10.4049/jimmunol.168.10.4920

72. Godfrey D.I., Uldrich A.P., McCluskey J., Rossjohn J.,Moody D.B. The burgeoning family of unconventional T cells. Nat Immunol, 2015, Vol.16, no 11, pp. 1114-23. 10.1038/ni.3298

73. Gogoi D., Dar A.A.,Chiplunkar S.V. Involvement of Notch in activation and effector functions of gammadelta T cells. J Immunol, 2014, Vol.192, no 5, pp. 2054-62. 10.4049/jimmunol.1300369

74. Goyal A., O'Leary D.,Duncan L.M. The significance of epidermal involvement in primary cutaneous gamma/delta (gammadelta) T-cell lymphoma: A systematic review and meta-analysis. J Cutan Pathol, 2021, Vol.48, no 12, pp. 1449-1454. 10.1111/cup.14082

75. Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H.,Spies T. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci U S A, 1999, Vol.96, no 12, pp. 6879-84. 10.1073/pnas.96.12.6879

76. Guo Y., Ziegler H.K., Safley S.A., Niesel D.W., Vaidya S.,Klimpel G.R. Human T-cell recognition of Listeria monocytogenes: recognition of listeriolysin O by TcR alpha beta + and TcR gamma delta + T cells. Infect Immun, 1995, Vol.63, no 6, pp. 2288-94. 10.1128/iai.63.6.2288-2294.1995

77. Hamada S., Umemura M., Shiono T., Tanaka K., Yahagi A., Begum M.D., Oshiro K., Okamoto Y., Watanabe H., Kawakami K., Roark C., Born W.K., O'Brien R., Ikuta K., Ishikawa H., Nakae S., Iwakura Y., Ohta T.,Matsuzaki G. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver. J Immunol, 2008, Vol.181, no 5, pp. 3456-63. 10.4049/jimmunol.181.5.3456

78. Harly C., Peigne C.M.,Scotet E. Molecules and Mechanisms Implicated in the Peculiar Antigenic Activation Process of Human Vgamma9Vdelta2 T Cells. Front Immunol, 2014, Vol.5, no, pp. 657. 10.3389/fimmu.2014.00657

79. Hayday A.C. [gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol, 2000, Vol.18, no, pp. 975-1026. 10.1146/annurev.immunol.18.1.975

80. Hilligan K.L.,Ronchese F. Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses. Cellular & Molecular Immunology, 2020, Vol.17, no 6, pp. 587-599. 10.1038/s41423-020-0465-0

81. Himoudi N., Morgenstern D.A., Yan M., Vernay B., Saraiva L., Wu Y., Cohen C.J., Gustafsson K.,Anderson J. Human gammadelta T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cells. J Immunol, 2012, Vol.188, no 4, pp. 1708-16. 10.4049/jimmunol.1102654

82. Holoshitz J., Vila L.M., Keroack B.J., McKinley D.R.,Bayne N.K. Dual antigenic recognition by cloned human gamma delta T cells. J Clin Invest, 1992, Vol.89, no 1, pp. 308-14. 10.1172/JCI115577

83. Hosokawa H.,Rothenberg E.V. How transcription factors drive choice of the T cell fate. Nat Rev Immunol, 2021, Vol.21, no 3, pp. 162-176. 10.1038/s41577-020-00426-6

84. Hu G., Wu P., Cheng P., Zhang Z., Wang Z., Yu X., Shao X., Wu D., Ye J., Zhang T., Wang X., Qiu F., Yan J.,Huang J. Tumor-infiltrating CD39(+)gammadeltaTregs are novel immunosuppressive T cells in human colorectal cancer. Oncoimmunology, 2017, Vol.6, no 2, pp. e1277305. 10.1080/2162402X.2016.1277305

85. Hu W., Shang R., Yang J., Chen C., Liu Z., Liang G., He W.,Luo G. Skin gammadelta T Cells and Their Function in Wound Healing. Front Immunol, 2022, Vol.13, no, pp. 875076. 10.3389/fimmu.2022.875076

86. Huang C., Zeng Y.,Tu W. The role of gammadelta-T cells during human pregnancy. Am J Reprod Immunol, 2017, Vol.78, no 2. 10.1111/aji.12713

87. Hueber W., Sands B.E., Lewitzky S., Vandemeulebroecke M., Reinisch W., Higgins P.D., Wehkamp J., Feagan B.G., Yao M.D., Karczewski M., Karczewski J., Pezous N., Bek S., Bruin G., Mellgard B., Berger C., Londei M., Bertolino A.P., Tougas G., Travis S.P.,Secukinumab in Crohn's Disease Study G. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut, 2012, Vol.61, no 12, pp. 1693-700. 10.1136/gutjnl-2011-301668

88. Hwang H.J., Lee J.J., Kang S.H., Suh J.K., Choi E.S., Jang S., Hwang S.H., Koh K.N., Im H.J.,Kim N. The BTLA and PD-1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood gammadelta T cells. Immun Inflamm Dis, 2021, Vol.9, no 1, pp. 274-287. 10.1002/iid3.390

89. Iwasaki M., Tanaka Y., Kobayashi H., Murata-Hirai K., Miyabe H., Sugie T., Toi M.,Minato N. Expression and function of PD-1 in human gammadelta T cells that recognize phosphoantigens. Eur J Immunol, 2011, Vol.41, no 2, pp. 345-55. 10.1002/eji.201040959

90. Jalali S., Stankovic S., Westall G.P., Reading P.C., Sullivan L.C.,Brooks A.G. Examining the impact of immunosuppressive drugs on antibody-dependent cellular cytotoxicity (ADCC) of human peripheral blood natural killer (NK) cells and gamma delta (gammadelta) T cells. Transpl Immunol, 2024, Vol.82, no, pp. 101962. 10.1016/j.trim.2023.101962

91. Jensen K.D., Su X., Shin S., Li L., Youssef S., Yamasaki S., Steinman L., Saito T., Locksley R.M., Davis M.M., Baumgarth N.,Chien Y.H. Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity, 2008, Vol.29, no 1, pp. 90-100. 10.1016/j.immuni.2008.04.022

92. Jia Z., Ren Z., Ye D., Li J., Xu Y., Liu H., Meng Z., Yang C., Chen X., Mao X., Luo X., Yang Z., Ma L., Deng A., Li Y., Han B., Wei J., Huang C., Xiang Z., Chen G., Li P., Ouyang J., Chen P., Luo O.J., Gao Y.,Yin Z. Immune-Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults. Phenomics, 2023, Vol.3, no 4, pp. 360-374. 10.1007/s43657-023-00106-0

93. Jin C., Lagoudas G.K., Zhao C., Bullman S., Bhutkar A., Hu B., Ameh S., Sandel D., Liang X.S., Mazzilli S., Whary M.T., Meyerson M., Germain R., Blainey P.C., Fox J.G.,Jacks T. Commensal Microbiota Promote Lung Cancer Development via gammadelta T Cells. Cell, 2019, Vol.176, no 5, pp. 998-1013 e16. 10.1016/j.cell.2018.12.040

94. Jin Y., Xia M., Sun A., Saylor C.M.,Xiong N. CCR10 is important for the development of skin-specific gammadeltaT cells by regulating their migration and location. J Immunol, 2010, Vol.185, no 10, pp. 5723-31. 10.4049/jimmunol.1001612

95. Kabelitz D., Serrano R., Kouakanou L., Peters C.,Kalyan S. Cancer immunotherapy with gammadelta T cells: many paths ahead of us. Cell Mol Immunol, 2020, Vol.17, no 9, pp. 925-939. 10.1038/s41423-020-0504-x

96. Kabelitz D.,Wesch D. Features and functions of gamma delta T lymphocytes: focus on chemokines and their receptors. Crit Rev Immunol, 2003, Vol.23, no 5-6, pp. 339-70. 10.1615/critrevimmunol.v23.i56.10

97. Kallemeijn M.J., Kavelaars F.G., van der Klift M.Y., Wolvers-Tettero I.L.M., Valk P.J.M., van Dongen J.J.M.,Langerak A.W. Next-Generation Sequencing Analysis of the Human TCRgammadelta+ T-Cell Repertoire Reveals Shifts in Vgamma- and Vdelta-Usage in Memory Populations upon Aging. Front Immunol, 2018, Vol.9, no, pp. 448. 10.3389/fimmu.2018.00448

98. Kaminski H., Marseres G., Cosentino A., Guerville F., Pitard V., Fournie J.J., Merville P., Dechanet-Merville J.,Couzi L. Understanding human gammadelta T cell biology toward a better management of cytomegalovirus infection. Immunol Rev, 2020, Vol.298, no 1, pp. 264-288. 10.1111/imr.12922

99. Kapp J.A., Kapp L.M., McKenna K.C.,Lake J.P. gammadelta T-cell clones from intestinal intraepithelial lymphocytes inhibit development of CTL responses ex vivo. Immunology, 2004, Vol.111, no 2, pp. 155-64. 10.1111/j.0019-2805.2003.01793.x

100. Karunakaran M.M., Willcox C.R., Salim M., Paletta D., Fichtner A.S., Noll A., Starick L., Nohren A., Begley C.R., Berwick K.A., Chaleil R.A.G., Pitard V., Dechanet-Merville J., Bates P.A., Kimmel B., Knowles T.J., Kunzmann V., Walter L., Jeeves M., Mohammed F., Willcox B.E.,Herrmann T. Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vgamma9Vdelta2 TCR and Is Essential for Phosphoantigen Sensing. Immunity, 2020, Vol.52, no 3, pp. 487-498 e6. 10.1016/j.immuni.2020.02.014

101. Karunathilaka A., Halstrom S., Price P., Holt M., Lutzky V.P., Doolan D.L., Kupz A., Bell S.C., Thomson R.M., Miles J.J.,Ratnatunga C.N. CD161 expression defines new human gammadelta T cell subsets. Immun Ageing, 2022, Vol.19, no 1, pp. 11. 10.1186/s12979-022-00269-w

102. Ke Y., Kapp L.M.,Kapp J.A. Inhibition of tumor rejection by gammadelta T cells and IL-10. Cell Immunol, 2003, Vol.221, no 2, pp. 107-14. 10.1016/s0008-8749(03)00066-2

103. Kenna T., Golden-Mason L., Norris S., Hegarty J.E., O'Farrelly C.,Doherty D.G. Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver. Clin Immunol, 2004, Vol.113, no 1, pp. 56-63. 10.1016/j.clim.2004.05.003

104. Khairallah C., Dechanet-Merville J.,Capone M. gammadelta T Cell-Mediated Immunity to Cytomegalovirus Infection. Front Immunol, 2017, Vol.8, no, pp. 105. 10.3389/fimmu.2017.00105

105. Kierkels G.J.J., Scheper W., Meringa A.D., Johanna I., Beringer D.X., Janssen A., Schiffler M., Aarts-Riemens T., Kramer L., Straetemans T., Heijhuurs S., Leusen J.H.W., San Jose E., Fuchs K., Griffioen M., Falkenburg J.H., Bongiovanni L., de Bruin A., Vargas-Diaz D., Altelaar M., Heck A.J.R., Shultz L.D., Ishikawa F., Nishimura M.I., Sebestyen Z.,Kuball J. Identification of a tumor-specific allo-HLA-restricted gammadeltaTCR. Blood Adv, 2019, Vol.3, no 19, pp. 2870-2882. 10.1182/bloodadvances.2019032409

106. Kim M., Kim H., Han M., Hwang H.J., Kim H., Im H.J., Kim N.,Koh K.N. Characteristics of Human Peripheral Blood gammadelta T Cells Expanded With Zoledronate. Anticancer Res, 2021, Vol.41, no 12, pp. 6031-6038. 10.21873/anticanres.15422

107. Kjer-Nielsen L., Patel O., Corbett A.J., Le Nours J., Meehan B., Liu L., Bhati M., Chen Z., Kostenko L., Reantragoon R., Williamson N.A., Purcell A.W., Dudek N.L., McConville M.J., O'Hair R.A., Khairallah G.N., Godfrey D.I., Fairlie D.P., Rossjohn J.,McCluskey J. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature, 2012, Vol.491, no 7426, pp. 717-23. 10.1038/nature11605

108. Kong Y., Cao W., Xi X., Ma C., Cui L.,He W. The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D. Blood, 2009, Vol.114, no 2, pp. 310-7. 10.1182/blood-2008-12-196287

109. Kornberg A., Botella T., Moon C.S., Rao S., Gelbs J., Cheng L., Miller J., Bacarella A.M., Garcia-Vilas J.A., Vargas J., Yu X., Krupska I., Bush E., Garcia-Carrasquillo R., Lebwohl B., Krishnareddy S., Lewis S., Green P.H.R., Bhagat G., Yan K.S.,Han A. Gluten induces rapid reprogramming of natural memory alphabeta and gammadelta intraepithelial T cells to induce cytotoxicity in celiac disease. Sci Immunol, 2023, Vol.8, no 85, pp. eadf4312. 10.1126/sciimmunol.adf4312

110. Kouakanou L., Peters C., Sun Q., Floess S., Bhat J., Huehn J.,Kabelitz D. Vitamin C supports conversion of human gammadelta T cells into FOXP3-expressing regulatory cells by epigenetic regulation. Sci Rep, 2020, Vol.10, no 1, pp. 6550. 10.1038/s41598-020-63572-w

111. Kozbor D., Trinchieri G., Monos D.S., Isobe M., Russo G., Haney J.A., Zmijewski C.,Croce C.M. Human TCR-gamma+/delta+, CD8+ T lymphocytes recognize tetanus toxoid in an MHC-restricted fashion. J Exp Med, 1989, Vol.169, no 5, pp. 1847-51. 10.1084/jem.169.5.1847

112. Kulicke C., Karamooz E., Lewinsohn D.,Harriff M. Covering All the Bases: Complementary MR1 Antigen Presentation Pathways Sample Diverse Antigens and Intracellular Compartments. Front Immunol, 2020, Vol.11, no, pp. 2034. 10.3389/fimmu.2020.02034

113. Lafont V., Sanchez F., Laprevotte E., Michaud H.A., Gros L., Eliaou J.F.,Bonnefoy N. Plasticity of gammadelta T Cells: Impact on the Anti-Tumor Response. Front Immunol, 2014, Vol.5, no, pp. 622. 10.3389/fimmu.2014.00622

114. Laggner U., Di Meglio P., Perera G.K., Hundhausen C., Lacy K.E., Ali N., Smith C.H., Hayday A.C., Nickoloff B.J.,Nestle F.O. Identification of a novel proinflammatory human skin-homing Vgamma9Vdelta2 T cell subset with a potential role in psoriasis. J Immunol, 2011, Vol.187, no 5, pp. 2783-93. 10.4049/jimmunol.1100804

115. Lalaoui N., Morle A., Merino D., Jacquemin G., Iessi E., Morizot A., Shirley S., Robert B., Solary E., Garrido C.,Micheau O. TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT. PLoS One, 2011, Vol.6, no 5, pp. e19679. 10.1371/journal.pone.0019679

116. Lamour A., Jouen-Beades F., Lees O., Gilbert D., Le Loet X.,Tron F. Analysis of T cell receptors in rheumatoid arthritis: the increased expression of HLA-DR antigen on circulating gamma delta+ T cells is correlated with disease activity. Clin Exp Immunol, 1992, Vol.89, no 2, pp. 217-22. 10.1111/j.1365-2249.1992.tb06935.x

117. Lanca T., Costa M.F., Goncalves-Sousa N., Rei M., Grosso A.R., Penido C.,Silva-Santos B. Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic gammadelta T lymphocytes to tumor beds. J Immunol, 2013, Vol.190, no 12, pp. 6673-80. 10.4049/jimmunol.1300434

118. Le Floch A.C., Rouviere M.S., Salem N., Ben Amara A., Orlanducci F., Vey N., Gorvel L., Chretien A.S.,Olive D. Prognostic Immune Effector Signature in Adult Acute Lymphoblastic Leukemia Patients Is Dominated by gammadelta T Cells. Cells, 2023, Vol.12, no 13. 10.3390/cells12131693

119. Lee D., Dunn Z.S., Guo W., Rosenthal C.J., Penn N.E., Yu Y., Zhou K., Li Z., Ma F., Li M., Song T.C., Cen X., Li Y.R., Zhou J.J., Pellegrini M., Wang P.,Yang L. Unlocking the potential of allogeneic Vdelta2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering. Nat Commun, 2023, Vol.14, no 1, pp. 6942. 10.1038/s41467-023-42619-2

120. Lee D., Rosenthal C.J., Penn N.E., Dunn Z.S., Zhou Y.,Yang L. Human gammadelta T Cell Subsets and Their Clinical Applications for Cancer Immunotherapy. Cancers (Basel), 2022, Vol.14, no 12. 10.3390/cancers14123005

121. Lee J.S., Tato C.M., Joyce-Shaikh B., Gulen M.F., Cayatte C., Chen Y., Blumenschein W.M., Judo M., Ayanoglu G., McClanahan T.K., Li X.,Cua D.J. Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity, 2015, Vol.43, no 4, pp. 727-38. 10.1016/j.immuni.2015.09.003

122. Lee M., Lee E., Han S.K., Choi Y.H., Kwon D.I., Choi H., Lee K., Park E.S., Rha M.S., Joo D.J., Shin E.C., Kim S., Kim J.K.,Lee Y.J. Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells. Nat Commun, 2020, Vol.11, no 1, pp. 4367. 10.1038/s41467-020-18155-8

123. Leon-Lara X., Yang T., Fichtner A.S., Bruni E., von Kaisenberg C., Eiz-Vesper B., Dodoo D., Adu B.,Ravens S. Evidence for an Adult-Like Type 1-Immunity Phenotype of Vdelta1, Vdelta2 and Vdelta3 T Cells in Ghanaian Children With Repeated Exposure to Malaria. Front Immunol, 2022, Vol.13, no, pp. 807765. 10.3389/fimmu.2022.807765

124. Lepore M., Kalinichenko A., Calogero S., Kumar P., Paleja B., Schmaler M., Narang V., Zolezzi F., Poidinger M., Mori L.,De Libero G. Functionally diverse human T cells recognize non-microbial antigens presented by MR1. Elife, 2017, Vol.6, no. 10.7554/eLife.24476

125. Lesport E., Baudhuin J., Sousa S., LeMaoult J., Zamborlini A., Rouas-Freiss N., Carosella E.D.,Favier B. Inhibition of human gamma delta [corrected] T-cell antitumoral activity through HLA-G: implications for immunotherapy of cancer. Cell Mol Life Sci, 2011, Vol.68, no 20, pp. 3385-99. 10.1007/s00018-011-0632-7

126. Li X., Lu H., Gu Y., Zhang X., Zhang G., Shi T.,Chen W. Tim-3 suppresses the killing effect of Vgamma9Vdelta2 T cells on colon cancer cells by reducing perforin and granzyme B expression. Exp Cell Res, 2020, Vol.386, no 1, pp. 111719. 10.1016/j.yexcr.2019.111719

127. Li Y., Jiang S., Li J., Yin M., Yan F., Chen Y., Chen Y., Wu T., Cheng M., He Y., Liang H., Yu H., Qiao Q., Guo Z., Xu Y., Zhang Y., Xiang Z.,Yin Z. Phenotypic Changes of Peripheral gammadelta T Cell and Its Subsets in Patients With Coronary Artery Disease. Front Immunol, 2022, Vol.13, no, pp. 900334. 10.3389/fimmu.2022.900334

128. Libera J., Wittner M., Kantowski M., Woost R., Eberhard J.M., de Heer J., Reher D., Huber S., Haag F.,Schulze Zur Wiesch J. Decreased Frequency of Intestinal CD39(+) gammadelta(+) T Cells With Tissue-Resident Memory Phenotype in Inflammatory Bowel Disease. Front Immunol, 2020, Vol.11, no, pp. 567472. 10.3389/fimmu.2020.567472

129. Liu B., He X., Wang Y., Huang J.W., Zheng Y.B., Li Y.,Lu L.G. Bibliometric Analysis of gammadelta T Cells as Immune Regulators in Cancer Prognosis. Front Immunol, 2022, Vol.13, no, pp. 874640. 10.3389/fimmu.2022.874640

130. Liu J., Wu M., Yang Y., Wang Z., He S., Tian X.,Wang H. gammadelta T cells and the PD-1/PD-L1 axis: a love-hate relationship in the tumor microenvironment. J Transl Med, 2024, Vol.22, no 1, pp. 553. 10.1186/s12967-024-05327-z

131. Lo Presti E., Dieli F., Fournie J.J.,Meraviglia S. Deciphering human gammadelta T cell response in cancer: Lessons from tumor-infiltrating gammadelta T cells. Immunol Rev, 2020, Vol.298, no 1, pp. 153-164. 10.1111/imr.12904

132. Lo Presti E., Dieli F.,Meraviglia S. Tumor-Infiltrating gammadelta T Lymphocytes: Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor Microenvironment. Front Immunol, 2014, Vol.5, no, pp. 607. 10.3389/fimmu.2014.00607

133. Ma C., Zhang Q., Ye J., Wang F., Zhang Y., Wevers E., Schwartz T., Hunborg P., Varvares M.A., Hoft D.F., Hsueh E.C.,Peng G. Tumor-infiltrating gammadelta T lymphocytes predict clinical outcome in human breast cancer. J Immunol, 2012, Vol.189, no 10, pp. 5029-36. 10.4049/jimmunol.1201892

134. Mangan B.A., Dunne M.R., O'Reilly V.P., Dunne P.J., Exley M.A., O'Shea D., Scotet E., Hogan A.E.,Doherty D.G. Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vdelta3 T cells. J Immunol, 2013, Vol.191, no 1, pp. 30-4. 10.4049/jimmunol.1300121

135. Maniar A., Zhang X., Lin W., Gastman B.R., Pauza C.D., Strome S.E.,Chapoval A.I. Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement. Blood, 2010, Vol.116, no 10, pp. 1726-33. 10.1182/blood-2009-07-234211

136. Mao T.L., Miao C.H., Liao Y.J., Chen Y.J., Yeh C.Y.,Liu C.L. Ex Vivo Expanded Human Vgamma9Vdelta2 T-Cells Can Suppress Epithelial Ovarian Cancer Cell Growth. Int J Mol Sci, 2019, Vol.20, no 5. 10.3390/ijms20051139

137. Mao Y., Yin S., Zhang J., Hu Y., Huang B., Cui L., Kang N.,He W. A new effect of IL-4 on human gammadelta T cells: promoting regulatory Vdelta1 T cells via IL-10 production and inhibiting function of Vdelta2 T cells. Cell Mol Immunol, 2016, Vol.13, no 2, pp. 217-28. 10.1038/cmi.2015.07

138. Marlin R., Pappalardo A., Kaminski H., Willcox C.R., Pitard V., Netzer S., Khairallah C., Lomenech A.M., Harly C., Bonneville M., Moreau J.F., Scotet E., Willcox B.E., Faustin B.,Dechanet-Merville J. Sensing of cell stress by human gammadelta TCR-dependent recognition of annexin A2. Proc Natl Acad Sci U S A, 2017, Vol.114, no 12, pp. 3163-3168. 10.1073/pnas.1621052114

139. Martinet L., Jean C., Dietrich G., Fournie J.J.,Poupot R. PGE2 inhibits natural killer and gamma delta T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling. Biochem Pharmacol, 2010, Vol.80, no 6, pp. 838-45. 10.1016/j.bcp.2010.05.002

140. Matsuo Y., Tsujimura T.,Drexler H.G. Proposal for the designation of the natural killer antigens-positive gammadelta T-cell subset as gammadelta NKT-cells: nomenclature based on immunoprofile. Hum Cell, 2021, Vol.34, no 4, pp. 1278-1279. 10.1007/s13577-021-00531-1

141. McGinley A.M., Edwards S.C., Raverdeau M.,Mills K.H.G. Th17 cells, gammadelta T cells and their interplay in EAE and multiple sclerosis. J Autoimmun, 2018 no. 10.1016/j.jaut.2018.01.001

142. McKenzie D.R., Hart R., Bah N., Ushakov D.S., Munoz-Ruiz M., Feederle R.,Hayday A.C. Normality sensing licenses local T cells for innate-like tissue surveillance. Nat Immunol, 2022, Vol.23, no 3, pp. 411-422. 10.1038/s41590-021-01124-8

143. McVay L.D.,Carding S.R. Extrathymic origin of human gamma delta T cells during fetal development. J Immunol, 1996, Vol.157, no 7, pp. 2873-82. https://www.ncbi.nlm.nih.gov/pubmed/8816392

144. McVay L.D.,Carding S.R. Generation of human gammadelta T-cell repertoires. Crit Rev Immunol, 1999, Vol.19, no 5-6, pp. 431-60. https://www.ncbi.nlm.nih.gov/pubmed/10647745

145. McVay L.D., Jaswal S.S., Kennedy C., Hayday A.,Carding S.R. The generation of human gammadelta T cell repertoires during fetal development. J Immunol, 1998, Vol.160, no 12, pp. 5851-60. https://www.ncbi.nlm.nih.gov/pubmed/9637496

146. Melandri D., Zlatareva I., Chaleil R.A.G., Dart R.J., Chancellor A., Nussbaumer O., Polyakova O., Roberts N.A., Wesch D., Kabelitz D., Irving P.M., John S., Mansour S., Bates P.A., Vantourout P.,Hayday A.C. The gammadeltaTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness. Nat Immunol, 2018, Vol.19, no 12, pp. 1352-1365. 10.1038/s41590-018-0253-5

147. Mensurado S., Blanco-Dominguez R.,Silva-Santos B. The emerging roles of gammadelta T cells in cancer immunotherapy. Nat Rev Clin Oncol, 2023, Vol.20, no 3, pp. 178-191. 10.1038/s41571-022-00722-1

148. Mensurado S.,Silva-Santos B. Battle of the gammadelta T cell subsets in the gut. Trends Cancer, 2022, Vol.8, no 11, pp. 881-883. 10.1016/j.trecan.2022.08.006

149. Meraviglia S., Lo Presti E., Tosolini M., La Mendola C., Orlando V., Todaro M., Catalano V., Stassi G., Cicero G., Vieni S., Fournie J.J.,Dieli F. Distinctive features of tumor-infiltrating gammadelta T lymphocytes in human colorectal cancer. Oncoimmunology, 2017, Vol.6, no 10, pp. e1347742. 10.1080/2162402X.2017.1347742

150. Merino D., Lalaoui N., Morizot A., Schneider P., Solary E.,Micheau O. Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol, 2006, Vol.26, no 19, pp. 7046-55. 10.1128/MCB.00520-06

151. Meuter S., Eberl M.,Moser B. Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells. Proc Natl Acad Sci U S A, 2010, Vol.107, no 19, pp. 8730-5. 10.1073/pnas.1002769107

152. Michel M.L., Pang D.J., Haque S.F., Potocnik A.J., Pennington D.J.,Hayday A.C. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells. Proc Natl Acad Sci U S A, 2012, Vol.109, no 43, pp. 17549-54. 10.1073/pnas.1204327109

153. Mikulak J., Oriolo F., Bruni E., Roberto A., Colombo F.S., Villa A., Bosticardo M., Bortolomai I., Lo Presti E., Meraviglia S., Dieli F., Vetrano S., Danese S., Della Bella S., Carvello M.M., Sacchi M., Cugini G., Colombo G., Klinger M., Spaggiari P., Roncalli M., Prinz I., Ravens S., di Lorenzo B., Marcenaro E., Silva-Santos B., Spinelli A.,Mavilio D. NKp46-expressing human gut-resident intraepithelial Vdelta1 T cell subpopulation exhibits high antitumor activity against colorectal cancer. JCI Insight, 2019, Vol.4, no 24. 10.1172/jci.insight.125884

154. Mo W.X., Yin S.S., Chen H., Zhou C., Zhou J.X., Zhao L.D., Fei Y.Y., Yang H.X., Guo J.B., Mao Y.J., Huang L.F., Zheng W.J., Zhang W., Zhang J.M., He W.,Zhang X. Chemotaxis of Vdelta2 T cells to the joints contributes to the pathogenesis of rheumatoid arthritis. Ann Rheum Dis, 2017, Vol.76, no 12, pp. 2075-2084. 10.1136/annrheumdis-2016-211069

155. Moens E., Brouwer M., Dimova T., Goldman M., Willems F.,Vermijlen D. IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17. J Leukoc Biol, 2011, Vol.89, no 5, pp. 743-52. 10.1189/jlb.0910501

156. Montaldo E., Del Zotto G., Della Chiesa M., Mingari M.C., Moretta A., De Maria A.,Moretta L. Human NK cell receptors/markers: a tool to analyze NK cell development, subsets and function. Cytometry A, 2013, Vol.83, no 8, pp. 702-13. 10.1002/cyto.a.22302

157. Mou W., Han W., Ma X., Wang X., Qin H., Zhao W., Ren X., Chen X., Yang W., Cheng H., Wang X., Zhang H., Ni X., Wang H.,Gui J. gammadeltaTFH cells promote B cell maturation and antibody production in neuroblastoma. BMC Immunol, 2017, Vol.18, no 1, pp. 36. 10.1186/s12865-017-0216-x

158. Munoz-Ruiz M., Ribot J.C., Grosso A.R., Goncalves-Sousa N., Pamplona A., Pennington D.J., Regueiro J.R., Fernandez-Malave E.,Silva-Santos B. TCR signal strength controls thymic differentiation of discrete proinflammatory gammadelta T cell subsets. Nat Immunol, 2016, Vol.17, no 6, pp. 721-727. 10.1038/ni.3424

159. Munoz-Ruiz M., Sumaria N., Pennington D.J.,Silva-Santos B. Thymic Determinants of gammadelta T Cell Differentiation. Trends Immunol, 2017, Vol.38, no 5, pp. 336-344. 10.1016/j.it.2017.01.007

160. Murray S.A., Mohar I., Miller J.L., Brempelis K.J., Vaughan A.M., Kappe S.H.,Crispe I.N. CD40 is required for protective immunity against liver stage Plasmodium infection. J Immunol, 2015, Vol.194, no 5, pp. 2268-79. 10.4049/jimmunol.1401724

161. Ness-Schwickerath K.J., Jin C.,Morita C.T. Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells. J Immunol, 2010, Vol.184, no 12, pp. 7268-80. 10.4049/jimmunol.1000600

162. Neumann S., Hasenauer J., Pollak N.,Scheurich P. Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes. J Biol Chem, 2014, Vol.289, no 23, pp. 16576-87. 10.1074/jbc.M114.559468

163. Ni C., Fang Q.Q., Chen W.Z., Jiang J.X., Jiang Z., Ye J., Zhang T., Yang L., Meng F.B., Xia W.J., Zhong M.,Huang J. Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+gammadelta1 Treg cells. Signal Transduct Target Ther, 2020, Vol.5, no 1, pp. 41. 10.1038/s41392-020-0129-7

164. Nielsen C.M., White M.J., Goodier M.R.,Riley E.M. Functional Significance of CD57 Expression on Human NK Cells and Relevance to Disease. Front Immunol, 2013, Vol.4, no, pp. 422. 10.3389/fimmu.2013.00422

165. Nielsen M.M., Witherden D.A.,Havran W.L. gammadelta T cells in homeostasis and host defence of epithelial barrier tissues. Nat Rev Immunol, 2017, Vol.17, no 12, pp. 733-745. 10.1038/nri.2017.101

166. Ning Z., Liu K.,Xiong H. Roles of BTLA in Immunity and Immune Disorders. Frontiers in Immunology, 2021, Vol.12, no. 10.3389/fimmu.2021.654960

167. Nowak I., Wilczynska K., Wilczynski J.R., Malinowski A., Radwan P., Radwan M.,Kusnierczyk P. KIR, LILRB and their Ligands' Genes as Potential Biomarkers in Recurrent Implantation Failure. Arch Immunol Ther Exp (Warsz), 2017, Vol.65, no 5, pp. 391-399. 10.1007/s00005-017-0474-6

168. Oberg H.H., Wesch D., Kalyan S.,Kabelitz D. Regulatory Interactions Between Neutrophils, Tumor Cells and T Cells. Front Immunol, 2019, Vol.10, no, pp. 1690. 10.3389/fimmu.2019.01690

169. Otano I., Azpilikueta A., Glez-Vaz J., Alvarez M., Medina-Echeverz J., Cortés-Domínguez I., Ortiz-de-Solorzano C., Ellmark P., Fritzell S., Hernandez-Hoyos G., Nelson M.H., Ochoa M.C., Bolaños E., Cuculescu D., Jaúregui P., Sanchez-Gregorio S., Etxeberria I., Rodriguez-Ruiz M.E., Sanmamed M.F., Teijeira Á., Berraondo P.,Melero I. CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation. Nature Communications, 2021, Vol.12, no 1. 10.1038/s41467-021-27613-w

170. Ou L., Wang H., Huang H., Zhou Z., Lin Q., Guo Y., Mitchell T., Huang A.C., Karakousis G., Schuchter L., Amaravadi R., Guo W., Salvino J., Herlyn M.,Xu X. Preclinical platforms to study therapeutic efficacy of human gammadelta T cells. Clin Transl Med, 2022, Vol.12, no 6, pp. e814. 10.1002/ctm2.814

171. Palakodeti A., Sandstrom A., Sundaresan L., Harly C., Nedellec S., Olive D., Scotet E., Bonneville M.,Adams E.J. The molecular basis for modulation of human Vgamma9Vdelta2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J Biol Chem, 2012, Vol.287, no 39, pp. 32780-90. 10.1074/jbc.M112.384354

172. Pan G., Ni J., Wei Y.F., Yu G., Gentz R.,Dixit V.M. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science, 1997, Vol.277, no 5327, pp. 815-8. 10.1126/science.277.5327.815

173. Papotto P.H., Reinhardt A., Prinz I.,Silva-Santos B. Innately versatile: gammadelta17 T cells in inflammatory and autoimmune diseases. J Autoimmun, 2018, Vol.87, no, pp. 26-37. 10.1016/j.jaut.2017.11.006

174. Papotto P.H., Ribot J.C.,Silva-Santos B. IL-17(+) gammadelta T cells as kick-starters of inflammation. Nat Immunol, 2017, Vol.18, no 6, pp. 604-611. 10.1038/ni.3726

175. Park J.H.,Lee H.K. Function of gammadelta T cells in tumor immunology and their application to cancer therapy. Exp Mol Med, 2021, Vol.53, no 3, pp. 318-327. 10.1038/s12276-021-00576-0

176. Patil R.S., Shah S.U., Shrikhande S.V., Goel M., Dikshit R.P.,Chiplunkar S.V. IL17 producing gammadeltaT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients. Int J Cancer, 2016, Vol.139, no 4, pp. 869-81. 10.1002/ijc.30134

177. Patin E.C., Soulard D., Fleury S., Hassane M., Dombrowicz D., Faveeuw C., Trottein F.,Paget C. Type I IFN Receptor Signaling Controls IL7-Dependent Accumulation and Activity of Protumoral IL17A-Producing gammadeltaT Cells in Breast Cancer. Cancer Res, 2018, Vol.78, no 1, pp. 195-204. 10.1158/0008-5472.CAN-17-1416

178. Paul S.,Lal G. Regulatory and effector functions of gamma-delta (gammadelta) T cells and their therapeutic potential in adoptive cellular therapy for cancer. Int J Cancer, 2016, Vol.139, no 5, pp. 976-85. 10.1002/ijc.30109

179. Pellicci D.G., Koay H.F.,Berzins S.P. Thymic development of unconventional T cells: how NKT cells, MAIT cells and gammadelta T cells emerge. Nat Rev Immunol, 2020, Vol.20, no 12, pp. 756-770. 10.1038/s41577-020-0345-y

180. Peters C., Hasler R., Wesch D.,Kabelitz D. Human Vdelta2 T cells are a major source of interleukin-9. Proc Natl Acad Sci U S A, 2016, Vol.113, no 44, pp. 12520-12525. 10.1073/pnas.1607136113

181. Peters C., Kabelitz D.,Wesch D. Regulatory functions of gammadelta T cells. Cell Mol Life Sci, 2018, Vol.75, no 12, pp. 2125-2135. 10.1007/s00018-018-2788-x

182. Peters C., Oberg H.H., Kabelitz D.,Wesch D. Phenotype and regulation of immunosuppressive Vdelta2-expressing gammadelta T cells. Cell Mol Life Sci, 2014, Vol.71, no 10, pp. 1943-60. 10.1007/s00018-013-1467-1

183. Poggi A., Carosio R., Fenoglio D., Brenci S., Murdaca G., Setti M., Indiveri F., Scabini S., Ferrero E.,Zocchi M.R. Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat. Blood, 2004, Vol.103, no 6, pp. 2205-13. 10.1182/blood-2003-08-2928

184. Poggi A., Contini P., Catellani S., Setti M., Murdaca G.,Zocchi M.R. Regulation of gammadelta T cell survival by soluble HLA-I: involvement of CD8 and activating killer Ig-like receptors. Eur J Immunol, 2005, Vol.35, no 9, pp. 2670-8. 10.1002/eji.200526177

185. Polgar B., Barakonyi A., Xynos I.,Szekeres-Bartho J. The role of gamma/delta T cell receptor positive cells in pregnancy. Am J Reprod Immunol, 1999, Vol.41, no 4, pp. 239-44. 10.1111/j.1600-0897.1999.tb00433.x

186. Poupot M., Pont F.,Fournie J.J. Profiling blood lymphocyte interactions with cancer cells uncovers the innate reactivity of human gamma delta T cells to anaplastic large cell lymphoma. J Immunol, 2005, Vol.174, no 3, pp. 1717-22. 10.4049/jimmunol.174.3.1717

187. Qu G., Wang S., Zhou Z., Jiang D., Liao A.,Luo J. Comparing Mouse and Human Tissue-Resident gammadelta T Cells. Front Immunol, 2022, Vol.13, no, pp. 891687. 10.3389/fimmu.2022.891687

188. Raulet D.H., Gasser S., Gowen B.G., Deng W.,Jung H. Regulation of ligands for the NKG2D activating receptor. Annu Rev Immunol, 2013, Vol.31, no, pp. 413-41. 10.1146/annurev-immunol-032712-095951

189. Ravens S., Hengst J., Schlapphoff V., Deterding K., Dhingra A., Schultze-Florey C., Koenecke C., Cornberg M., Wedemeyer H.,Prinz I. Human gammadelta T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy. Front Immunol, 2018, Vol.9, no, pp. 510. 10.3389/fimmu.2018.00510

190. Ravens S., Schultze-Florey C., Raha S., Sandrock I., Drenker M., Oberdorfer L., Reinhardt A., Ravens I., Beck M., Geffers R., von Kaisenberg C., Heuser M., Thol F., Ganser A., Forster R., Koenecke C.,Prinz I. Human gammadelta T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol, 2017, Vol.18, no 4, pp. 393-401. 10.1038/ni.3686

191. Rei M., Goncalves-Sousa N., Lanca T., Thompson R.G., Mensurado S., Balkwill F.R., Kulbe H., Pennington D.J.,Silva-Santos B. Murine CD27(-) Vgamma6(+) gammadelta T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A, 2014, Vol.111, no 34, pp. E3562-70. 10.1073/pnas.1403424111

192. Reis B.S., Darcy P.W., Khan I.Z., Moon C.S., Kornberg A.E., Schneider V.S., Alvarez Y., Eleso O., Zhu C., Schernthanner M., Lockhart A., Reed A., Bortolatto J., Castro T.B.R., Bilate A.M., Grivennikov S., Han A.S.,Mucida D. TCR-Vgammadelta usage distinguishes protumor from antitumor intestinal gammadelta T cell subsets. Science, 2022, Vol.377, no 6603, pp. 276-284. 10.1126/science.abj8695

193. Ren S., Zhang X., Guan H., Wu L., Yu M., Hou D., Yan Y.,Fang X. Lactobacillus acidipiscis Induced Regulatory Gamma Delta T Cells and Attenuated Experimental Autoimmune Encephalomyelitis. Front Immunol, 2021, Vol.12, no, pp. 623451. 10.3389/fimmu.2021.623451

194. Ribot J.C., deBarros A., Pang D.J., Neves J.F., Peperzak V., Roberts S.J., Girardi M., Borst J., Hayday A.C., Pennington D.J.,Silva-Santos B. CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat Immunol, 2009, Vol.10, no 4, pp. 427-36. 10.1038/ni.1717

195. Ribot J.C., debarros A.,Silva-Santos B. Searching for "signal 2": costimulation requirements of gammadelta T cells. Cell Mol Life Sci, 2011, Vol.68, no 14, pp. 2345-55. 10.1007/s00018-011-0698-2

196. Ribot J.C., Lopes N.,Silva-Santos B. gammadelta T cells in tissue physiology and surveillance. Nat Rev Immunol, 2021, Vol.21, no 4, pp. 221-232. 10.1038/s41577-020-00452-4

197. Ribot J.C., Ribeiro S.T., Correia D.V., Sousa A.E.,Silva-Santos B. Human gammadelta thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling. J Immunol, 2014, Vol.192, no 5, pp. 2237-43. 10.4049/jimmunol.1303119

198. Rice M.T., von Borstel A., Chevour P., Awad W., Howson L.J., Littler D.R., Gherardin N.A., Le Nours J., Giles E.M., Berry R., Godfrey D.I., Davey M.S., Rossjohn J.,Gully B.S. Recognition of the antigen-presenting molecule MR1 by a Vdelta3(+) gammadelta T cell receptor. Proc Natl Acad Sci U S A, 2021, Vol.118, no 49. 10.1073/pnas.2110288118

199. Ridgley L.A., Caron J., Dalgleish A.,Bodman-Smith M. Releasing the restraints of Vgamma9Vdelta2 T-cells in cancer immunotherapy. Front Immunol, 2022, Vol.13, no, pp. 1065495. 10.3389/fimmu.2022.1065495

200. Rigau M., Ostrouska S., Fulford T.S., Johnson D.N., Woods K., Ruan Z., McWilliam H.E.G., Hudson C., Tutuka C., Wheatley A.K., Kent S.J., Villadangos J.A., Pal B., Kurts C., Simmonds J., Pelzing M., Nash A.D., Hammet A., Verhagen A.M., Vairo G., Maraskovsky E., Panousis C., Gherardin N.A., Cebon J., Godfrey D.I., Behren A.,Uldrich A.P. Butyrophilin 2A1 is essential for phosphoantigen reactivity by gammadelta T cells. Science, 2020, Vol.367, no 6478. 10.1126/science.aay5516

201. Riol-Blanco L., Lazarevic V., Awasthi A., Mitsdoerffer M., Wilson B.S., Croxford A., Waisman A., Kuchroo V.K., Glimcher L.H.,Oukka M. IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol, 2010, Vol.184, no 4, pp. 1710-20. 10.4049/jimmunol.0902796

202. Robak E., Niewiadomska H., Robak T., Bartkowiak J., Blonski J.Z., Wozniacka A., Pomorski L.,Sysa-Jedrezejowska A. Lymphocyctes Tgammadelta in clinically normal skin and peripheral blood of patients with systemic lupus erythematosus and their correlation with disease activity. Mediators Inflamm, 2001, Vol.10, no 4, pp. 179-89. 10.1080/09629350124724

203. Rodin W., Szeponik L., Rangelova T., Tamiru Kebede F., Osterlund T., Sundstrom P., Hogg S., Wettergren Y., Cosma A., Stahlberg A., Bexe Lindskog E.,Quiding Jarbrink M. gammadelta T cells in human colon adenocarcinomas comprise mainly Vdelta1, Vdelta2, and Vdelta3 cells with distinct phenotype and function. Cancer Immunol Immunother, 2024, Vol.73, no 9, pp. 174. 10.1007/s00262-024-03758-7

204. Rothenberg E.V. Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human. Exp Hematol, 2021, Vol.95, no, pp. 1-12. 10.1016/j.exphem.2020.12.005

205. Roura-Mir C., Catalfamo M., Cheng T.Y., Marqusee E., Besra G.S., Jaraquemada D.,Moody D.B. CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis. J Immunol, 2005, Vol.174, no 6, pp. 3773-80. 10.4049/jimmunol.174.6.3773

206. Roy S., Ly D., Castro C.D., Li N.S., Hawk A.J., Altman J.D., Meredith S.C., Piccirilli J.A., Moody D.B.,Adams E.J. Molecular Analysis of Lipid-Reactive Vdelta1 gammadelta T Cells Identified by CD1c Tetramers. J Immunol, 2016, Vol.196, no 4, pp. 1933-42. 10.4049/jimmunol.1502202

207. Rust C.J., Verreck F., Vietor H.,Koning F. Specific recognition of staphylococcal enterotoxin A by human T cells bearing receptors with the V gamma 9 region. Nature, 1990, Vol.346, no 6284, pp. 572-4. 10.1038/346572a0

208. Ryan P.L., Sumaria N., Holland C.J., Bradford C.M., Izotova N., Grandjean C.L., Jawad A.S., Bergmeier L.A.,Pennington D.J. Heterogeneous yet stable Vdelta2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals. Proc Natl Acad Sci U S A, 2016, Vol.113, no 50, pp. 14378-14383. 10.1073/pnas.1611098113

209. Sanchez-Correa B., Valhondo I., Hassouneh F., Lopez-Sejas N., Pera A., Bergua J.M., Arcos M.J., Banas H., Casas-Aviles I., Duran E., Alonso C., Solana R.,Tarazona R. DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy. Cancers (Basel), 2019, Vol.11, no 6. 10.3390/cancers11060877

210. Sandstrom A., Peigne C.M., Leger A., Crooks J.E., Konczak F., Gesnel M.C., Breathnach R., Bonneville M., Scotet E.,Adams E.J. The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vgamma9Vdelta2 T cells. Immunity, 2014, Vol.40, no 4, pp. 490-500. 10.1016/j.immuni.2014.03.003

211. Schonefeldt S., Wais T., Herling M., Mustjoki S., Bekiaris V., Moriggl R.,Neubauer H.A. The Diverse Roles of gammadelta T Cells in Cancer: From Rapid Immunity to Aggressive Lymphoma. Cancers (Basel), 2021, Vol.13, no 24. 10.3390/cancers13246212

212. Sebestyen Z., Prinz I., Dechanet-Merville J., Silva-Santos B.,Kuball J. Translating gammadelta (gammadelta) T cells and their receptors into cancer cell therapies. Nat Rev Drug Discov, 2020, Vol.19, no 3, pp. 169-184. 10.1038/s41573-019-0038-z

213. Seifert A.M., List J., Heiduk M., Decker R., von Renesse J., Meinecke A.C., Aust D.E., Welsch T., Weitz J.,Seifert L. Gamma-delta T cells stimulate IL-6 production by pancreatic stellate cells in pancreatic ductal adenocarcinoma. J Cancer Res Clin Oncol, 2020, Vol.146, no 12, pp. 3233-3240. 10.1007/s00432-020-03367-8

214. Shah D.K.,Zuniga-Pflucker J.C. An overview of the intrathymic intricacies of T cell development. J Immunol, 2014, Vol.192, no 9, pp. 4017-23. 10.4049/jimmunol.1302259

215. Shibata K., Yamada H., Hara H., Kishihara K.,Yoshikai Y. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol, 2007, Vol.178, no 7, pp. 4466-72. 10.4049/jimmunol.178.7.4466

216. Si F., Liu X., Tao Y., Zhang Y., Ma F., Hsueh E.C., Puram S.V.,Peng G. Blocking senescence and tolerogenic function of dendritic cells induced by gammadelta Treg cells enhances tumor-specific immunity for cancer immunotherapy. J Immunother Cancer, 2024, Vol.12, no 4. 10.1136/jitc-2023-008219

217. Siblany L., Stocker N., Ricard L., Brissot E., Dulery R., Banet A., Sestili S., Belhocine R., Van de Wyngaert Z., Bonnin A., Capes A., Ledraa T., Beurier P., Fadel K., Mohty M., Gaugler B.,Malard F. Unconventional T Cells Influence Clinical Outcome After Allogeneic Hematopoietic Cell Transplantation. J Clin Immunol, 2024, Vol.44, no 6, pp. 139. 10.1007/s10875-024-01741-6

218. Silva-Santos B. Promoting angiogenesis within the tumor microenvironment: the secret life of murine lymphoid IL-17-producing gammadelta T cells. Eur J Immunol, 2010, Vol.40, no 7, pp. 1873-6. 10.1002/eji.201040707

219. Silva-Santos B., Mensurado S.,Coffelt S.B. gammadelta T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nat Rev Cancer, 2019, Vol.19, no 7, pp. 392-404. 10.1038/s41568-019-0153-5

220. Silva-Santos B., Schamel W.W., Fisch P.,Eberl M. gammadelta T-cell conference 2012: close encounters for the fifth time. Eur J Immunol, 2012, Vol.42, no 12, pp. 3101-5. 10.1002/eji.201270101

221. Silva-Santos B., Serre K.,Norell H. gammadelta T cells in cancer. Nat Rev Immunol, 2015, Vol.15, no 11, pp. 683-91. 10.1038/nri3904

222. Simoes A.E., Di Lorenzo B.,Silva-Santos B. Molecular Determinants of Target Cell Recognition by Human gammadelta T Cells. Front Immunol, 2018, Vol.9, no, pp. 929. 10.3389/fimmu.2018.00929

223. Simon S.,Labarriere N. PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy? Oncoimmunology, 2017, Vol.7, no 1, pp. e1364828. 10.1080/2162402X.2017.1364828

224. Spada F.M., Grant E.P., Peters P.J., Sugita M., Melian A., Leslie D.S., Lee H.K., van Donselaar E., Hanson D.A., Krensky A.M., Majdic O., Porcelli S.A., Morita C.T.,Brenner M.B. Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity. J Exp Med, 2000, Vol.191, no 6, pp. 937-48. 10.1084/jem.191.6.937

225. Spits H., Paliard X., Engelhard V.H.,de Vries J.E. Cytotoxic activity and lymphokine production of T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2 and HLA-A2 mutants. Recognition of TCR-gamma delta+ CTL clones is affected by mutations at positions 152 and 156. J Immunol, 1990, Vol.144, no 11, pp. 4156-62. https://www.ncbi.nlm.nih.gov/pubmed/2111341

226. Suen T.K., Moorlag S., Li W., de Bree L.C.J., Koeken V., Mourits V.P., Dijkstra H., Lemmers H., Bhat J., Xu C.J., Joosten L.A.B., Schultze J.L., Li Y., Placek K.,Netea M.G. BCG vaccination induces innate immune memory in gammadelta T cells in humans. J Leukoc Biol, 2024, Vol.115, no 1, pp. 149-163. 10.1093/jleuko/qiad103

227. Suliman S., Geldenhuys H., Johnson J.L., Hughes J.E., Smit E., Murphy M., Toefy A., Lerumo L., Hopley C., Pienaar B., Chheng P., Nemes E., Hoft D.F., Hanekom W.A., Boom W.H., Hatherill M.,Scriba T.J. Bacillus Calmette-Guerin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses. J Immunol, 2016, Vol.197, no 4, pp. 1100-1110. 10.4049/jimmunol.1501996

228. Sumaria N., Grandjean C.L., Silva-Santos B.,Pennington D.J. Strong TCRgammadelta Signaling Prohibits Thymic Development of IL-17A-Secreting gammadelta T Cells. Cell Rep, 2017, Vol.19, no 12, pp. 2469-2476. 10.1016/j.celrep.2017.05.071

229. Sun H., Sun C.,Xiao W. Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine, 2014, Vol.65, no 1, pp. 33-41. 10.1016/j.cyto.2013.09.016

230. Sutton C.E., Lalor S.J., Sweeney C.M., Brereton C.F., Lavelle E.C.,Mills K.H. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity, 2009, Vol.31, no 2, pp. 331-41. 10.1016/j.immuni.2009.08.001

231. Talukdar A., Rai R., Aparna Sharma K., Rao D.N.,Sharma A. Peripheral Gamma Delta T cells secrete inflammatory cytokines in women with idiopathic recurrent pregnancy loss. Cytokine, 2018, Vol.102, no, pp. 117-122. 10.1016/j.cyto.2017.07.018

232. Tan G., Spillane K.M.,Maher J. The Role and Regulation of the NKG2D/NKG2D Ligand System in Cancer. Biology (Basel), 2023, Vol.12, no 8. 10.3390/biology12081079

233. Taupin J.L., Halary F., Dechanet J., Peyrat M.A., Ragnaud J.M., Bonneville M.,Moreau J.F. An enlarged subpopulation of T lymphocytes bearing two distinct gammadelta TCR in an HIV-positive patient. Int Immunol, 1999, Vol.11, no 4, pp. 545-52. 10.1093/intimm/11.4.545

234. Terzieva A., Dimitrova V., Djerov L., Dimitrova P., Zapryanova S., Hristova I., Vangelov I.,Dimova T. Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires. Int J Mol Sci, 2019, Vol.20, no 3. 10.3390/ijms20030687

235. Tieppo P., Papadopoulou M., Gatti D., McGovern N., Chan J.K.Y., Gosselin F., Goetgeluk G., Weening K., Ma L., Dauby N., Cogan A., Donner C., Ginhoux F., Vandekerckhove B.,Vermijlen D. The human fetal thymus generates invariant effector gammadelta T cells. J Exp Med, 2020, Vol.217, no 3. 10.1084/jem.20190580

236. Tilloy F., Treiner E., Park S.H., Garcia C., Lemonnier F., de la Salle H., Bendelac A., Bonneville M.,Lantz O. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med, 1999, Vol.189, no 12, pp. 1907-21. 10.1084/jem.189.12.1907

237. Tomogane M., Sano Y., Shimizu D., Shimizu T., Miyashita M., Toda Y., Hosogi S., Tanaka Y., Kimura S.,Ashihara E. Human Vgamma9Vdelta2 T cells exert anti-tumor activity independently of PD-L1 expression in tumor cells. Biochem Biophys Res Commun, 2021, Vol.573, no, pp. 132-139. 10.1016/j.bbrc.2021.08.005

238. Toulon A., Breton L., Taylor K.R., Tenenhaus M., Bhavsar D., Lanigan C., Rudolph R., Jameson J.,Havran W.L. A role for human skin-resident T cells in wound healing. J Exp Med, 2009, Vol.206, no 4, pp. 743-50. 10.1084/jem.20081787

239. Toutirais O., Cabillic F., Le Friec G., Salot S., Loyer P., Le Gallo M., Desille M., de La Pintiere C.T., Daniel P., Bouet F.,Catros V. DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vgamma9Vdelta2 T cells. Eur J Immunol, 2009, Vol.39, no 5, pp. 1361-8. 10.1002/eji.200838409

240. Towstyka N.Y., Shiromizu C.M., Keitelman I., Sabbione F., Salamone G.V., Geffner J.R., Trevani A.S.,Jancic C.C. Modulation of gammadelta T-cell activation by neutrophil elastase. Immunology, 2018, Vol.153, no 2, pp. 225-237. 10.1111/imm.12835

241. Treiner E., Duban L., Bahram S., Radosavljevic M., Wanner V., Tilloy F., Affaticati P., Gilfillan S.,Lantz O. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature, 2003, Vol.422, no 6928, pp. 164-9. 10.1038/nature01433

242. Trowsdale J.,Moffett A. NK receptor interactions with MHC class I molecules in pregnancy. Semin Immunol, 2008, Vol.20, no 6, pp. 317-20. 10.1016/j.smim.2008.06.002

243. Tsai C.Y., Liong K.H., Gunalan M.G., Li N., Lim D.S., Fisher D.A., MacAry P.A., Leo Y.S., Wong S.C., Puan K.J.,Wong S.B. Type I IFNs and IL-18 regulate the antiviral response of primary human gammadelta T cells against dendritic cells infected with Dengue virus. J Immunol, 2015, Vol.194, no 8, pp. 3890-900. 10.4049/jimmunol.1303343

244. Tuengel J., Ranchal S., Maslova A., Aulakh G., Papadopoulou M., Drissler S., Cai B., Mohsenzadeh-Green C., Soudeyns H., Mostafavi S., van den Elzen P., Vermijlen D., Cook L.,Gantt S. Characterization of Adaptive-like gammadelta T Cells in Ugandan Infants during Primary Cytomegalovirus Infection. Viruses, 2021, Vol.13, no 10. 10.3390/v13101987

245. Tyler C.J., Doherty D.G., Moser B.,Eberl M. Human Vgamma9/Vdelta2 T cells: Innate adaptors of the immune system. Cell Immunol, 2015, Vol.296, no 1, pp. 10-21. 10.1016/j.cellimm.2015.01.008

246. Tyler C.J., McCarthy N.E., Lindsay J.O., Stagg A.J., Moser B.,Eberl M. Antigen-Presenting Human gammadelta T Cells Promote Intestinal CD4(+) T Cell Expression of IL-22 and Mucosal Release of Calprotectin. J Immunol, 2017, Vol.198, no 9, pp. 3417-3425. 10.4049/jimmunol.1700003

247. Tyshchuk E.V., Mikhailova V.A., Selkov S.A.,Sokolov D.I. Natural killer cells: origin, phenotype, function. Medical Immunology (Russia), 2021, Vol.23, no 6, pp. 1207-1228. 10.15789/1563-0625-nkc-2330

248. Uehara S., Song K., Farber J.M.,Love P.E. Characterization of CCR9 expression and CCL25/thymus-expressed chemokine responsiveness during T cell development: CD3(high)CD69+ thymocytes and gammadeltaTCR+ thymocytes preferentially respond to CCL25. J Immunol, 2002, Vol.168, no 1, pp. 134-42. 10.4049/jimmunol.168.1.134

249. Ullrich R., Schieferdecker H.L., Ziegler K., Riecken E.O.,Zeitz M. gamma delta T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium. Cell Immunol, 1990, Vol.128, no 2, pp. 619-27. 10.1016/0008-8749(90)90053-t

250. Van Coppernolle S., Vanhee S., Verstichel G., Snauwaert S., van der Spek A., Velghe I., Sinnesael M., Heemskerk M.H., Taghon T., Leclercq G., Plum J., Langerak A.W., Kerre T.,Vandekerckhove B. Notch induces human T-cell receptor gammadelta+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway. Leukemia, 2012, Vol.26, no 1, pp. 127-38. 10.1038/leu.2011.324

251. Van de Walle I., De Smet G., De Smedt M., Vandekerckhove B., Leclercq G., Plum J.,Taghon T. An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. Blood, 2009, Vol.113, no 13, pp. 2988-98. 10.1182/blood-2008-06-164871

252. Van Rhijn I., Godfrey D.I., Rossjohn J.,Moody D.B. Lipid and small-molecule display by CD1 and MR1. Nat Rev Immunol, 2015, Vol.15, no 10, pp. 643-54. 10.1038/nri3889

253. von Karstedt S., Montinaro A.,Walczak H. Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy. Nat Rev Cancer, 2017, Vol.17, no 6, pp. 352-366. 10.1038/nrc.2017.28

254. von Lilienfeld-Toal M., Nattermann J., Feldmann G., Sievers E., Frank S., Strehl J.,Schmidt-Wolf I.G. Activated gammadelta T cells express the natural cytotoxicity receptor natural killer p 44 and show cytotoxic activity against myeloma cells. Clin Exp Immunol, 2006, Vol.144, no 3, pp. 528-33. 10.1111/j.1365-2249.2006.03078.x

255. Walczak H., Degli-Esposti M.A., Johnson R.S., Smolak P.J., Waugh J.Y., Boiani N., Timour M.S., Gerhart M.J., Schooley K.A., Smith C.A., Goodwin R.G.,Rauch C.T. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J, 1997, Vol.16, no 17, pp. 5386-97. 10.1093/emboj/16.17.5386

256. Wang C., Lai A.Y., Baiu D.C., Smith K.A., Odorico J.S., Wilson K., Schreiber T., de Silva S.,Gumperz J.E. Analysis of Butyrophilin-Mediated Activation of gammadelta T Cells from Human Spleen. J Immunol, 2024, Vol.212, no 2, pp. 284-294. 10.4049/jimmunol.2300588

257. Wang L., Xu M., Wang C., Zhu L., Hu J., Chen S., Wu X., Li B.,Li Y. The feature of distribution and clonality of TCR gamma/delta subfamilies T cells in patients with B-cell non-Hodgkin lymphoma. J Immunol Res, 2014, Vol.2014, no, pp. 241246. 10.1155/2014/241246

258. Wegrecki M., Ocampo T.A., Gunasinghe S.D., von Borstel A., Tin S.Y., Reijneveld J.F., Cao T.P., Gully B.S., Le Nours J., Moody D.B., Van Rhijn I.,Rossjohn J. Atypical sideways recognition of CD1a by autoreactive gammadelta T cell receptors. Nat Commun, 2022, Vol.13, no 1, pp. 3872. 10.1038/s41467-022-31443-9

259. Wen L.,Hayday A.C. Gamma delta T-cell help in responses to pathogens and in the development of systemic autoimmunity. Immunol Res, 1997, Vol.16, no 3, pp. 229-41. 10.1007/BF02786392

260. Wesch D., Glatzel A.,Kabelitz D. Differentiation of resting human peripheral blood gamma delta T cells toward Th1- or Th2-phenotype. Cell Immunol, 2001, Vol.212, no 2, pp. 110-7. 10.1006/cimm.2001.1850

261. Wesch D., Hinz T.,Kabelitz D. Analysis of the TCR Vgamma repertoire in healthy donors and HIV-1-infected individuals. Int Immunol, 1998, Vol.10, no 8, pp. 1067-75. 10.1093/intimm/10.8.1067

262. Wesch D., Kabelitz D.,Oberg H.H. Tumor resistance mechanisms and their consequences on gammadelta T cell activation. Immunol Rev, 2020, Vol.298, no 1, pp. 84-98. 10.1111/imr.12925

263. Wesch D., Peters C., Oberg H.H., Pietschmann K.,Kabelitz D. Modulation of gammadelta T cell responses by TLR ligands. Cell Mol Life Sci, 2011, Vol.68, no 14, pp. 2357-70. 10.1007/s00018-011-0699-1

264. Willcox B.E.,Willcox C.R. gammadelta TCR ligands: the quest to solve a 500-million-year-old mystery. Nat Immunol, 2019, Vol.20, no 2, pp. 121-128. 10.1038/s41590-018-0304-y

265. Willcox C.R., Davey M.S.,Willcox B.E. Development and Selection of the Human Vgamma9Vdelta2(+) T-Cell Repertoire. Front Immunol, 2018, Vol.9, no, pp. 1501. 10.3389/fimmu.2018.01501

266. Willcox C.R., Mohammed F.,Willcox B.E. The distinct MHC-unrestricted immunobiology of innate-like and adaptive-like human gammadelta T cell subsets-Nature's CAR-T cells. Immunol Rev, 2020, Vol.298, no 1, pp. 25-46. 10.1111/imr.12928

267. Willcox C.R., Pitard V., Netzer S., Couzi L., Salim M., Silberzahn T., Moreau J.F., Hayday A.C., Willcox B.E.,Dechanet-Merville J. Cytomegalovirus and tumor stress surveillance by binding of a human gammadelta T cell antigen receptor to endothelial protein C receptor. Nat Immunol, 2012, Vol.13, no 9, pp. 872-9. 10.1038/ni.2394

268. Willcox C.R., Vantourout P., Salim M., Zlatareva I., Melandri D., Zanardo L., George R., Kjaer S., Jeeves M., Mohammed F., Hayday A.C.,Willcox B.E. Butyrophilin-like 3 Directly Binds a Human Vgamma4(+) T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen. Immunity, 2019, Vol.51, no 5, pp. 813-825 e4. 10.1016/j.immuni.2019.09.006

269. Wistuba-Hamprecht K., Martens A., Haehnel K., Geukes Foppen M., Yuan J., Postow M.A., Wong P., Romano E., Khammari A., Dreno B., Capone M., Ascierto P.A., Demuth I., Steinhagen-Thiessen E., Larbi A., Schilling B., Schadendorf D., Wolchok J.D., Blank C.U., Pawelec G., Garbe C.,Weide B. Proportions of blood-borne Vdelta1+ and Vdelta2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab. Eur J Cancer, 2016, Vol.64, no, pp. 116-26. 10.1016/j.ejca.2016.06.001

270. Woo S.R., Corrales L.,Gajewski T.F. Innate immune recognition of cancer. Annu Rev Immunol, 2015, Vol.33, no 1, pp. 445-74. 10.1146/annurev-immunol-032414-112043

271. Wu C., Cao X.,Zhang X. VISTA inhibitors in cancer immunotherapy: a short perspective on recent progresses. RSC Med Chem, 2021, Vol.12, no 10, pp. 1672-1679. 10.1039/d1md00185j

272. Wu J., Groh V.,Spies T. T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells. J Immunol, 2002, Vol.169, no 3, pp. 1236-40. 10.4049/jimmunol.169.3.1236

273. Wu K., Feng J., Xiu Y., Li Z., Lin Z., Zhao H., Zeng H., Xia W., Yu L.,Xu B. Vdelta2 T cell subsets, defined by PD-1 and TIM-3 expression, present varied cytokine responses in acute myeloid leukemia patients. Int Immunopharmacol, 2020, Vol.80, no, pp. 106122. 10.1016/j.intimp.2019.106122

274. Wu P., Wu D., Ni C., Ye J., Chen W., Hu G., Wang Z., Wang C., Zhang Z., Xia W., Chen Z., Wang K., Zhang T., Xu J., Han Y., Zhang T., Wu X., Wang J., Gong W., Zheng S., Qiu F., Yan J.,Huang J. gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity, 2014, Vol.40, no 5, pp. 785-800. 10.1016/j.immuni.2014.03.013

275. Wu X., Yang T., Liu X., Guo J.N., Xie T., Ding Y., Lin M.,Yang H. IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric cancer. Tumour Biol, 2016, Vol.37, no 4, pp. 5493-501. 10.1007/s13277-015-4372-4

276. Wu Y., Wu W., Wong W.M., Ward E., Thrasher A.J., Goldblatt D., Osman M., Digard P., Canaday D.H.,Gustafsson K. Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis. J Immunol, 2009, Vol.183, no 9, pp. 5622-9. 10.4049/jimmunol.0901772

277. Wun K.S., Reijneveld J.F., Cheng T.Y., Ladell K., Uldrich A.P., Le Nours J., Miners K.L., McLaren J.E., Grant E.J., Haigh O.L., Watkins T.S., Suliman S., Iwany S., Jimenez J., Calderon R., Tamara K.L., Leon S.R., Murray M.B., Mayfield J.A., Altman J.D., Purcell A.W., Miles J.J., Godfrey D.I., Gras S., Price D.A., Van Rhijn I., Moody D.B.,Rossjohn J. T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nat Immunol, 2018, Vol.19, no 4, pp. 397-406. 10.1038/s41590-018-0065-7

278. Xi X., Han X., Li L.,Zhao Z. Identification of a new tuberculosis antigen recognized by gammadelta T cell receptor. Clin Vaccine Immunol, 2013, Vol.20, no 4, pp. 530-9. 10.1128/CVI.00584-12

279. Xi X., Zhang X., Wang B., Wang J., Huang H., Cui L., Han X., Li L., He W.,Zhao Z. A novel strategy to screen Bacillus Calmette-Guerin protein antigen recognized by gammadelta TCR. PLoS One, 2011, Vol.6, no 4, pp. e18809. 10.1371/journal.pone.0018809

280. Xiao H., Lin R., Chen C., Lian R., Wu Y., Diao L., Yin T.,Huang C. gammadelta-T cell with high toxic potential was associated with recurrent miscarriage. Am J Reprod Immunol, 2023, Vol.90, no 1, pp. e13717. 10.1111/aji.13717

281. Xu R., Jacques L.C., Khandaker S., Beentjes D., Leon-Rios M., Wei X., French N., Neill D.R.,Kadioglu A. TNFR2(+) regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing gammadelta T cells in the lung. Cell Rep, 2023, Vol.42, no 2, pp. 112054. 10.1016/j.celrep.2023.112054

282. Xu W., Lau Z.W.X., Fulop T.,Larbi A. The Aging of gammadelta T Cells. Cells, 2020, Vol.9, no 5. 10.3390/cells9051181

283. Xu Y., Xiang Z., Alnaggar M., Kouakanou L., Li J., He J., Yang J., Hu Y., Chen Y., Lin L., Hao J., Li J., Chen J., Li M., Wu Q., Peters C., Zhou Q., Li J., Liang Y., Wang X., Han B., Ma M., Kabelitz D., Xu K., Tu W., Wu Y.,Yin Z. Allogeneic Vgamma9Vdelta2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer. Cell Mol Immunol, 2021, Vol.18, no 2, pp. 427-439. 10.1038/s41423-020-0515-7

284. Yan J., Allen S., McDonald E., Das I., Mak J.Y.W., Liu L., Fairlie D.P., Meehan B.S., Chen Z., Corbett A.J., Varelias A., Smyth M.J.,Teng M.W.L. MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1. Cancer Discov, 2020, Vol.10, no 1, pp. 124-141. 10.1158/2159-8290.CD-19-0569

285. Yang Q., Liu X., Liu Q., Guan Z., Luo J., Cao G., Cai R., Li Z., Xu Y., Wu Z., Xu M., Zhang S., Zhang F., Yang H., Lin X., Yang M., Wu Y., Gao Y., Flavell R., Hao J.,Yin Z. Roles of mTORC1 and mTORC2 in controlling gammadelta T1 and gammadelta T17 differentiation and function. Cell Death Differ, 2020, Vol.27, no 7, pp. 2248-2262. 10.1038/s41418-020-0500-9

286. Yang X., Zhan N., Jin Y., Ling H., Xiao C., Xie Z., Zhong H., Yu X., Tang R., Ma J., Guan J., Yin G., Wu G., Lu L.,Wang J. Tofacitinib restores the balance of gammadeltaTreg/gammadeltaT17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome. Theranostics, 2021, Vol.11, no 3, pp. 1446-1457. 10.7150/thno.47860

287. Yao Y.E., Qin C.C., Yang C.M.,Huang T.X. gammadeltaT17/gammadeltaTreg cell subsets: a new paradigm for asthma treatment. J Asthma, 2022, Vol.59, no 10, pp. 2028-2038. 10.1080/02770903.2021.1980585

288. Ye J., Ma C., Hsueh E.C., Eickhoff C.S., Zhang Y., Varvares M.A., Hoft D.F.,Peng G. Tumor-derived gammadelta regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence. J Immunol, 2013, Vol.190, no 5, pp. 2403-14. 10.4049/jimmunol.1202369

289. Ye J., Ma C., Wang F., Hsueh E.C., Toth K., Huang Y., Mo W., Liu S., Han B., Varvares M.A., Hoft D.F.,Peng G. Specific recruitment of gammadelta regulatory T cells in human breast cancer. Cancer Res, 2013, Vol.73, no 20, pp. 6137-48. 10.1158/0008-5472.CAN-13-0348

290. Yi Y., He H.W., Wang J.X., Cai X.Y., Li Y.W., Zhou J., Cheng Y.F., Jin J.J., Fan J.,Qiu S.J. The functional impairment of HCC-infiltrating gammadelta T cells, partially mediated by regulatory T cells in a TGFbeta- and IL-10-dependent manner. J Hepatol, 2013, Vol.58, no 5, pp. 977-83. 10.1016/j.jhep.2012.12.015

291. Young J.L., Goodall J.C., Beacock-Sharp H.,Gaston J.S. Human gamma delta T-cell recognition of Yersinia enterocolitica. Immunology, 1997, Vol.91, no 4, pp. 503-10. 10.1046/j.1365-2567.1997.00289.x

292. Yuan S., Wang C., Zeng Y., Li J., Li W., He Z., Ye J., Li F., Chen Y., Lin X., Xu Y., Yu N.,Cai X. Aberrant phenotypes of circulating gammadelta-T cells may be involved in the onset of systemic lupus erythematosus. Lupus, 2024, Vol.33, no 6, pp. 587-597. 10.1177/09612033241240864

293. Zakeri N., Hall A., Swadling L., Pallett L.J., Schmidt N.M., Diniz M.O., Kucykowicz S., Amin O.E., Gander A., Pinzani M., Davidson B.R., Quaglia A.,Maini M.K. Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma. Nat Commun, 2022, Vol.13, no 1, pp. 1372. 10.1038/s41467-022-29012-1

294. Zarin P., Wong G.W., Mohtashami M., Wiest D.L.,Zuniga-Pflucker J.C. Enforcement of gammadelta-lineage commitment by the pre-T-cell receptor in precursors with weak gammadelta-TCR signals. Proc Natl Acad Sci U S A, 2014, Vol.111, no 15, pp. 5658-63. 10.1073/pnas.1312872111

295. Zhang M., Ge T., Zhang Y.,La X. Identification of MARK2, CCDC71, GATA2, and KLRC3 as candidate diagnostic genes and potential therapeutic targets for repeated implantation failure with antiphospholipid syndrome by integrated bioinformatics analysis and machine learning. Front Immunol, 2023, Vol.14, no, pp. 1126103. 10.3389/fimmu.2023.1126103

296. Zhang Y., Cado D., Asarnow D.M., Komori T., Alt F.W., Raulet D.H.,Allison J.P. The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus. Immunity, 1995, Vol.3, no 4, pp. 439-47. 10.1016/1074-7613(95)90173-6

297. Zhang Z., Yang C., Li L., Zhu Y., Su K., Zhai L., Wang Z.,Huang J. "gammadeltaT Cell-IL17A-Neutrophil" Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy. Front Immunol, 2021, Vol.12, no, pp. 699478. 10.3389/fimmu.2021.699478

298. Zhao Y., Niu C.,Cui J. Gamma-delta (gammadelta) T cells: friend or foe in cancer development? J Transl Med, 2018, Vol.16, no 1, pp. 3. 10.1186/s12967-017-1378-2

299. Zhou J., Kang N., Cui L., Ba D.,He W. Anti-gammadelta TCR antibody-expanded gammadelta T cells: a better choice for the adoptive immunotherapy of lymphoid malignancies. Cell Mol Immunol, 2012, Vol.9, no 1, pp. 34-44. 10.1038/cmi.2011.16

300. Zhu X., Sakamoto S., Ishii C., Smith M.D., Ito K., Obayashi M., Unger L., Hasegawa Y., Kurokawa S., Kishimoto T., Li H., Hatano S., Wang T.H., Yoshikai Y., Kano S.I., Fukuda S., Sanada K., Calabresi P.A.,Kamiya A. Dectin-1 signaling on colonic gammadelta T cells promotes psychosocial stress responses. Nat Immunol, 2023, Vol.24, no 4, pp. 625-636. 10.1038/s41590-023-01447-8

301. Zingoni A., Molfetta R., Fionda C., Soriani A., Paolini R., Cippitelli M., Cerboni C.,Santoni A. NKG2D and Its Ligands: "One for All, All for One". Front Immunol, 2018, Vol.9, no, pp. 476. 10.3389/fimmu.2018.00476