PROTIA™ Allergy-Q Atopy® in the diagnosis of allergy in psoriasis

Recently, one of the important areas of scientific research is the relationship between autoimmune diseases and atopy. There is evidence of a relationship between atopy and psoriasis. Our studies have shown that in some cases psoriasis and atopy (in particular, food allergy) have a cause-and-effect relationship, which is proven not only by the establishment of sensitization, but also by the positive effect of elimination against the background of elimination therapy. Thus, the study of the concentration of sIgE to 44 causally significant allergens using the PROTIA™ Allergy-Q test system (atopic panel) by the immunoblotting method in this study is of particular relevance.
Objective: to conduct a comparative analysis of the presence of allergen-specific IgE to food, fungal, pollen, household and epidermal allergens in the blood serum of patients with psoriasis using the immunoblotting method using the Allergy-Q® test system.
Materials and methods. The study included patients with psoriasis (PS, group 1, n=51). The comparison group was patients with atopic dermatitis (AD, group 2, n=20). The average age of patients in group 1 was 40.0±1.8 years, in group 2 – 25.0±2.0 years. The control group consisted of practically healthy individuals comparable with patients by gender and age (group 3, n=19). All patients underwent a specific allergological examination, including collection of an allergological anamnesis, determination of the level of total immunoglobulin E (IgE) in the blood serum and the sensitization spectrum based on the analysis of the concentration of allergen-specific IgE (sIgE) to 44 most common allergens in the blood serum by immunoblotting using the Allergy-Q® test system (atopic panel) (Korea). Statistical processing of the obtained results was carried out using the application program "Statistica 8.0".
Research results. The concentration of total immunoglobulin E in the blood serum was statistically significantly higher in the group of patients with AD compared to PS and the control. Sensitization of atopic genesis was noted in 35.3% (n=18) of patients with psoriasis and in 90% (n=18) of patients with atopic dermatitis. In the group of patients with AD, the most significant food allergen was peach compared to the group of patients with PS and the control. Sensitization to potato, rice, peanut, peach was statistically significantly higher in the group of patients with PS compared to the control. In the group of patients with AD, the most common pollen allergen was wormwood pollen. In the group of patients with AD, sensitization to ragweed, wormwood, alder-birch mixture pollen was statistically significantly higher compared to the control group. In psoriasis, the highest frequency of sensitization to ragweed pollen was found in comparison with the group of patients with AD and the control group.
When analyzing the structure of sensitization to fungal allergens, it was found that sensitization to Candida albicans was determined statistically significantly more often in the group of patients with PS in comparison with the group of patients with AD and the control group. An increase in the frequency of sensitization to cat and dog epithelium was noted in the groups of patients with PS and AD in comparison with the control group. In the group of patients with PS, a statistically significant increase in the frequency of sensitization to Staphylococcal enterotoxin B was noted in comparison with the group of patients with AD and the control group.
Conclusion. Thus, our study should draw attention to the problem of skin damage in psoriasis from the position of an allergist-immunologist. This justifies the need for a specific allergological examination of patients with psoriasis in order to establish causative allergens, especially in the case of a severe course of the disease.

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