Evaluation of lipid profiles in patients with chronic spontaneous urticaria: A case-control study
https://doi.org/10.15789/1563-0625-EOL-2928
Abstract
Chronic urticaria is referred to recurrent, pruritic, erythematous, and edematous mucocutaneous lesions on most days of the week, and persists for six weeks or more. There is a hypothesis about the levels of blood lipid profiles in CSU, which may have a contributing role in development or exacerbation of hives attacks. The present study was conducted to investigate the association between chronic urticaria and blood lipid profiles. Fifty patients with chronic urticaria and fifty healthy people were included in this case-control study. In chronic urticaria patients, each parameters of blood lipid profile and urticaria severity were evaluated in each of four age and two sex cathegories. Urticaria severity in chronic urticaria patients, was also analyzed for levels of HDL, LDL, Triglyceride and Cholesterol. Levels of triglyceride (p value = 0.039), total cholesterol (p value = 0.031), and LDL (p value = 0.001) were significantly higher in chronic urticaria patients than in control group. No correlation was found between the urticaria severity (UAS7 score) average, and the age and sex of the patients. Urticaria severity showed no significant difference within each lipid profile parameter. Average values of lipid profiles in patients with chronic urticaria in different age and sex showed that HDL has remarkably higher mean quantitation in women than men (p < 0.002). Our study found a correlation between chronic urticaria with hyperlipidemia. According to this investigation, we can advise that patients with chronic urticaria should be evaluated for hyperlipidemia.
About the Authors
Abbas Khalili
Shahid Sadoughi University of Medical Sciences
Islamic Republic of Iran
Islamic Republic of Iran
Abbas Khalili, MD, Associate Professor of Shahid Sadoughi University of Medica Sciences, Department of Pediatrics, Shahid Sadoughi Hospital
Yazd
Fatemeh Azadi Talab Davoudabadi
Shahid Sadoughi University of Medical Sciences
Islamic Republic of Iran
Islamic Republic of Iran
Fatemeh Azadi Talab Davoudabadi, MD, General Physician, Department of Pediatrics, Shahid Sadoughi Hospital
Yazd
Bamdad Sadeghi
University of Medical Sciences
Islamic Republic of Iran
Islamic Republic of Iran
Bamdad Sadeghi, MD, General Physician, Research Center for Immunodeficiencies, Children’s Medical Center
Tehran
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For citations:
Khalili A., Azadi Talab Davoudabadi F., Sadeghi B. Evaluation of lipid profiles in patients with chronic spontaneous urticaria: A case-control study. Medical Immunology (Russia). 2025;27(2):329-334. https://doi.org/10.15789/1563-0625-EOL-2928
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