Preview

Медицинская иммунология

Расширенный поиск

γδТ-ЛИМФОЦИТЫ: ОБЩАЯ ХАРАКТЕРИСТИКА, СУБПОПУЛЯЦИОННЫЙ СОСТАВ, БИОЛОГИЧЕСКАЯ РОЛЬ И ФУНКЦИОНАЛЬНЫЕ ОСОБЕННОСТИ

https://doi.org/10.15789/1563-0625-2009-2-3-115-130

Аннотация

Резюме. γδТ-лимфоциты представляют собой малоизученную гетерогенную популяцию Т-лимфоцитов, доминирующую в слизистых оболочках и сочетающую в себе свойства как клеток врожденного, так и приобретенного иммунитета. Отсутствие процессинга и МНС-рестрикции обуславливает способность γδТ-клеток идентифицировать широкий спектр антигенов, природа которых, как и механизм распознавания, до конца не установлены. Многообразие биологических функций, основными из которых являются цитолиз, иммунорегуляция, презентация антигена и репарация поврежденных тканей, определяют уникальную роль данной популяции при инфекционных, опухолевых и аутоиммунных заболеваниях. В настоящий момент, основные уcилия исследователей направлены на изучение терапевтического потенциала γδТ-лимфоцитов, поиск и продукцию γδТ-клеточных агонистов, а также планирование и оптимизацию терапевтических протоколов, мишенью которых являются γδТ-лимфоциты.

Об авторах

Д. Б. Нижегородова
Белорусская медицинская академия последипломного образования, г. Минск
Россия

иммунологическая группа, Центральная научно-исследовательская лаборатория

220073, ул. Притыцкого, 18, корп. 3, кв. 35. Тел.: (+375-17) 265-33-56. Факс: (+375-17) 265-46-43


М. М. Зафранская
Белорусская медицинская академия последипломного образования, г. Минск
Россия

иммунологическая группа, Центральная научно-исследовательская лаборатория



Список литературы

1. Adams E., Chien Y-H., Garcia K. Structure of a γδT cell receptor in complex with the nonclassical MHC T22 // Science. – 2005. – Vol. 308. – P. 227 - 231.

2. Beissert S., Schwarz A., Schwarz T. Regulatory T cells // Journal of Investigative Dermatology. – 2006. – Vol. 126. – P. 15-24.

3. Boismenu R., Havran W. Intraepithelial γδT cells exposed by functional genomics // Genome Biology. – 2001. – Vol. 2 –P. 1031-1035.

4. Bonneville M., Scotet E. Human Vγ9Vδ2 T cell: promising new leads for immunotherapy of infections and tumors // Current Opinion in Immunology. – 2006. – Vol. 18. – P. 539-546.

5. Bonneville M. Selection of intraepithelial γδT cells: the holy GrIEL at last? // Nature Immunology. – 2006. – Vol. 7. – P. 791-792.

6. Bonneville M., Fournie J. Sensing cell stress and transformation through Vγ9Vδ2 T-cell mediated recognition of the isoprenoid pathway metabolites // Microbes Infection. – 2005. – Vol. 7. – P. 503-509.

7. Born W., Jin N., Aydintung K., Wands J., French J., Roark C., O’Brien R. γδT lymphocytes – selectable cells within the innate system? // Journal of Clinical Immunology. – 2007. – Vol. 7. – P. 133 - 144.

8. Born W., Reardon R., O’Brien R. The function of γδT cells in innate immunity // Current Opinion in Immunology. – 2006. – Vol. 18. – P. 31-38.

9. Brandes M., Willimann K., Lang A., Nam K., Jin C., Brenner M., Morita C., Moser B. Flexible migration program regulates γδ T cell involvement in humoral immunity // Blood. – 2003. – Vol. 102. – P. 3693-3701.

10. Brandes M., Willimann K., Moser B. Professional antigen-presentation function by human γδT cells // Science. – 2005. – Vol. 309. – P. 264 - 268.

11. Brenner M., McLean J., Dialynas D., Strominger J., Smith J., Owen F., Seidman J., Ip. S., Rosen F., Krangel M. Identification of a putative second T cell receptor // Nature. – 1986. – Vol. 322. – P. 145-149.

12. Carding S., Egan P. γδТ cells: functional plasticity and heterogeneity // Nature Reviews. – 2002. – Vol. 2. – P. 336-345.

13. Cassetti R., Martino A. The plasticity of gamma delta T cells: innate immunity, antigen and new immunotherapy // Cell Mol Immunol. – 2008. – Vol. 5. – P. 161-170.

14. Chien Y-U., Jores R., Crowley M. Recognition by γ/δT cells // Annual Reviews Immunology. – 1996. – Vol. 14. – P. 511-532.

15. Chien Y-U., Konigshofer Y. Antigen recognition by γδT cells // Immunological Reviews. – 2007. – Vol. 15. – P. 46-58.

16. Crowley M., Reich Z., Mavaddat N., Altman J., Chien Y-H. The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the γδT cell, G8 // J. Exp. Med. – 1997. – Vol. 185. – P. 1223-1230.

17. Das H., Groh V., Kuijl C., Sugita M., Morita C., Spies T., Bukowski J. MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigendependent effector function // Immunity. – 2001. – Vol. 15. – P. 83-93.

18. Davis M., Bjorkman P. T cell antigen receptor genes and T cell recognition // Nature. – 1988. – Vol. 334. – P. 395-402.

19. De Rosa S., Andrus J., Perfetto S., Mantovani J., Herzenberg L., Roederer M. Ontogeny of γδ T cells in humans // J. Immunol. – 2004. – Vol. 172. –P. 1637 - 1645.

20. Dieli F., Poccia F., Lipp M., Sireci G., Caccamo N., Di Sano C., Salerno A. Differentiation of effector/memory Vδ2 T cells and migratory routes in lymph nodes or inflammatory sites // J. Exp. Med. – 2003. – Vol. 198. – P. 391-397.

21. Girardi M. Immunosurveillance and immunoregulation by γδT cells // Journal of Investigative Dermatology. – 2006. – Vol. 126. – P. 25-31.

22. Gober H., Kistowska M., Angman L., Jeno P., Mori L., De Libero G. Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells // J. Exp. Med. – 2003. – Vol. 197. – P. 163-168.

23. Groh V., Steinle A., Bauer S., Spies T. Recognition of stess-induced MHC molecules by intestinal epithelial γδT cells // Science. – 1998. – Vol. 79. – P. 1737-1740.

24. Hänninen A., Harrison L. γδT cells as mediators of mucosal tolerance: the autoimmune diabetes model // Immunolodical reviews. – 2000. – Vol. 173. – P. 109-119.

25. Hayday A., Tigelaar R. Immunoregulation in the tissues by γδT cells // Nature Reviews. – 2003. – Vol. 3. – P.233-242.

26. Hayday A. γδ cells: a right time and a right place for a conserved third way of protection // Annual Reviews Immunology. – 2000. – Vol. 18. – P. 975 - 1026.

27. Hayday A., Theodoridis E., Ramsburg E., Shires J. Intraepithelial lymphocytes: exploring the third way in immunology // Nature Immunology. – 2001. – Vol. 2 – P. 997-1003.

28. Jameson J., Havran W. Skin γδT cell functions in homeostasis and wound healing // Immunological Reviews. – 2007. – Vol. 15. – P. 114-122.

29. Jomaa H., Feurle J., Luhs K., Kunzmann V., Tony H., Herderich M., Wilhelm M. Vγ9/Vδ2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis // FEMS Immunol Med Microbiol. – 1999. – Vol. 5. – P. 371-378.

30. Kabelitz D., Marischen L., Oberg H., Holtmeier W., Wesch D. Epithelial defence by γδТ cells // International Archives Allergy Immunology. – 2005. – Vol.137. – P. 73-81.

31. Kabelitz D., Wesch D., He W. Perspectives of gammadelta T cells in tumor immunology // Cancer Research. – 2007. – Vol. 67. – P. 5-8.

32. Kapp J., Kapp L., McKenna K. Gammadelta T cells pla an essential role in several forms of tolerance // Immunology Research. – 2004. – Vol. 9. – P. 93-102.

33. Kronenberg M., Havran W. Frontline T cells: γδT cells and intraepithelial lymphocytes // Immunological Reviews. – 2007. – Vol. 15. – P. 5-7.

34. Kusnierczyk P. Antigen peptide/MHC complex as an initiator of a signal for lymphocyte T activation // Postepy Hiq. Med. Dosw. – 1999. – Vol. 53. – P. 331 - 341.

35. Mincheva-Nilsson L. Pregnancy and γδТ cells: taking on the hard questions // Reproductive Biology and Endocrinology. – 2003. – Vol. 1. – P. 120-131.

36. Morita C., Beckman E., Bukowski J., Tanaka Y., Band H., Bloom B., Golan D., Brenner M. Direct presentation of nonpeptide prenylpyrophosphate antigens to human γδ T cells // Immunity. – 1995. – Vol. 3. – P. 495-507.

37. Morita C., Jin C., Sarikonda G., Wang H. Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2Vδ2 cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens // Immunological Reviews. – 2007. – Vol. 215. – P. 59-76.

38. Moser B., Brandes M. γδ T cells: an alternative type of professional APC // Trends in Immunology. – 2006. – Vol. 27. – P. 112-118.

39. Moser B., Eberl M. γδT cells: novel initiators of adaptive immunity // Immunological Reviews. – 2007. – Vol. 215. – P. 89-102.

40. Münz C., Steinman R., Fujii S. Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity // Journal of Experimental Medicine. – 2005. – Vol. 202. – P. 203-207.

41. Nanno M., Shiohara T., Yamamoto H., Kawakami K., Ishikawa H. γδT cells: firefighters or fire boosters in the front lines of inflammatory responses // Immunological Reviews. – 2007. – Vol. 215. – P. 103-113.

42. Odyniec A., Szczepanik M., Mycko M., Stasiolek M., Raine C., Selmaj K. γδT cellsenhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 production // The Journal of Immunology. – 2004. – Vol. 173. – P. 682-694.

43. Pennington D., Vermijlen D., Wise E., Clarke S., Tigelaar R., Hayday A. The integration of conventional and unconventional T cells that characterizes cell-mediated responses // Advances in Immunology. – 2005. – Vol. 87. – P.27-59.

44. Poggi A., Catellani S., Fenoglio D., Borsellino G., Battistini L., Zocchi M. Adhesion molecules and kinases involved in gammadelta T cells migratory pathways: implications for viral and autoimmune diseases // Curr. Med. Chem. – 2007. – Vol. 14. – P. 3166-3170.

45. Porcelli S., Brenner M., Greenstein J., Balk S., Terhorst C., Bleicher P. Recognition of cluster of differentiational antigens by human CD4-CD8- cytolytic T lymphocytes // Nature. – 1989. – Vol. 341. – P. 447-450.

46. Scotet E., Martinez L., Grant E., Barbaras R., Jeno P., Saulquin X. Tumor recognition following Vγ9Vδ2 T cell receptor interactions with a surface F1 - ATPase-related structure and apolipoprotein A-1 // Immunity. – 2005. – Vol. 22. – P. 71-80.

47. Spada F., Grant E., Peters P., Sugita M., Melian A., Leslie D., Lee H., van Donselaar E., Hanson D., Krensky A., Majdic O., Porcelli S., Morita C., Brenner M. Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity // J. Exp. Med. – 2000. – Vol. 191. – P. 937-948.

48. Tanaka Y., Morita C., Nieves E., Brenner M., Bloom B. Natural and synthetic non-peptide antigens recognized by human γδT cells // Nature. – 1995. – Vol. 375. – P. 155-158.

49. Thedrez A., Sabourin C., Gertner J., Devilder M., Allain-Maillet S., Fournie J., Scotet E., Bonneville M. Self/non-self discrimination by human γδT cells: simple solutions for a complex issue? // Immunological Reviews. – 2007. – Vol. 15. – P. 123 - 135.

50. Thompson K., Rogers M. Statins prevent biphosphonate-induced gamma delta T cell proliferation and activation in vitro // J. Bone Miner. Res. – 2004. – Vol. 19. – P. 278-288.

51. Thompson K., Rojas-Navea J., Rogers M. Alkylamines cause Vg9Vd2 T cell activation and proliferation by inhibiting the mevalonate pathway // Blood. – 2006. – Vol. 107. – P. 651-654.

52. Viey E., Fromont G., Escudier B., Morel Y., Da Rocha S., Chouaib S., Caignard A. Phosphostim activated gamma delta T cells kill autologous metastatic renal cell carcinoma // J. Immunol. – 2005. – Vol. 174. – P. 1338-1347.

53. Von Lilienfeld-Toal M., Nattermann J., Feldmann G., Sievers E., Frank S., Strehl J., Schmidt-Wolf I. Activated γδ T cells express the natural cytotoxicity receptor natural killer p44 and show cytotoxic activity against myeloma cells // Clin Exp. Immunol. – 2006. – Vol. 144. – P. 528-533.

54. Wands J., Roark C., Aydintung M., Jin N., Hahn Y.-S., Cook L. Distribution and leukocyte contacts of gdT cells in the lung // J. Leukocyte Biol. – 2005. – Vol. 78. – P. 1086-1096.

55. Wang H., Lee H., Bulowski J., Li H., Mariuzza R., Chen Z., Nam K., Morita C. Conservation of nonprptide antigen recognition by rhesus monkey Vγ9Vδ2 Т cells // J. Immunol. – 2003. – Vol.170. – P. 3696-3706.

56. Zhao H., Nguyen H., Kang J. Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gd intestinal intraepithelial lymphocytes // Nat. Immunol. – 2005. – Vol. 6. – P. 1263-1271.


Рецензия

Для цитирования:


Нижегородова Д.Б., Зафранская М.М. γδТ-ЛИМФОЦИТЫ: ОБЩАЯ ХАРАКТЕРИСТИКА, СУБПОПУЛЯЦИОННЫЙ СОСТАВ, БИОЛОГИЧЕСКАЯ РОЛЬ И ФУНКЦИОНАЛЬНЫЕ ОСОБЕННОСТИ. Медицинская иммунология. 2009;11(2-3):115-130. https://doi.org/10.15789/1563-0625-2009-2-3-115-130

For citation:


Nizhegorodova D.B., Zafranskaya M.M. γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES. Medical Immunology (Russia). 2009;11(2-3):115-130. (In Russ.) https://doi.org/10.15789/1563-0625-2009-2-3-115-130

Просмотров: 1881


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)