γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES
https://doi.org/10.15789/1563-0625-2009-2-3-115-130
Abstract
Abstract. γδТ lymphocytes represent a poorly investigated heterogeneous population of T cells that are found, predominantly, in mucosal structures, and express common characteristics of innate and acquired immunity. Lack of both antigen processing and MHC-restriction determines an ability of γδТ cells to identify broad spectrum of antigens, the origin of which is yet unknown, and the recognition mechanism have been not established yet. A variety of biological functions, first of all, cytolysis, immune regulation, antigen presentation and repair of tissue damage, define a unique role of this population in infectious diseases, tumors, and autoimmune disorders. Nowadays, principal efforts of scientists are directed to investigation of γδТ cell therapeutic potential, search and production of γδТ cell agonists, as well as design and optimization of herapeutic protocols that may be targeted to γδТ lymphocytes.
About the Authors
D. B. Nizhegorodova
Белорусская медицинская академия последипломного образования, г. Минск
Russian Federation
Russian Federation
M. M. Zafranskaya
Белорусская медицинская академия последипломного образования, г. Минск
Russian Federation
Russian Federation
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Review
For citations:
Nizhegorodova D.B., Zafranskaya M.M. γδТ-LYMPHOCYTES: GENERAL CHARACTERISTICS, SUBPOPULATION PROFILE, BIOLOGICAL ROLE, AND FUNCTIONAL FEATURES. Medical Immunology (Russia). 2009;11(2-3):115-130. (In Russ.) https://doi.org/10.15789/1563-0625-2009-2-3-115-130
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