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Cytokine profile in the patients with combined cardio- and ophtalmopathies

https://doi.org/10.15789/1563-0625-CPO-2639

Abstract

Combined cardiological and ophthalmological pathology has a high prevalence in older age groups of the population and common pathogenetic mechanisms, among which, of course, is a violation of the cytokine profile. However, the cytokine profile of the blood was practically not analyzed in elderly patients with combined ischemic heart disease with glaucoma. The aim of the study was to study the cytokine profile in patients with combined cardio- and ophthalmopathology. The study was performed at the S.N. Fedorov National Medical Research Center “MNTK Eye Microsurgery”, in two groups: patients with combined coronary heart disease with glaucoma (n = 58 people), and patients with coronary heart disease (n = 49 people), who in both cases have the same age of 60-74 years. The diagnosis of glaucoma was carried out in accordance with the criteria of the “National Glaucoma Guidelines”. Electrocardiographic, echocardiographic, radiographic, and enzyme studies were performed to diagnose coronary heart disease. The determination of cytokines in blood plasma was carried out on the device “Becton Dickinson FACS Canto 2 (USA)” using a special set of CBA (BD Biosciences, USA). Among the patients of the compared groups of the same age, significant differences in most cytokines were revealed, namely, a predominant increase in patients with combined cardio- and ophthalmopathology relative to the group with coronary heart disease. The content of IL-5, IL-12, IFNγ, TNFα in the blood plasma of patients with coronary heart disease combined with glaucoma increased with a significant difference compared to patients with coronary heart disease. However, the highest increase among the cytokines under consideration is characteristic of IL-6 and IL-17, which amounted to 23.8±1.1 pg/mL and 20.2±1.7 pg/mL in patients with combined cardio- and ophthalmopathology versus 6.3±0.3 pg/mL and 7.9±0.5 pg/mL, respectively, in patients with coronary heart disease. At the same time, the level of IL-4 and IL-10 decreased significantly to 2.2±0.2 pg/mL and 6.4±0.4 pg/mL versus 4.8±0.3 pg/mL and 11.9±0.6 pg/mL. The use of logistic regression made it possible to determine the relative risk values of the studied blood cytokines and to develop uncorrected and adjusted models, according to which the closest association with the risk of developing combined coronary heart disease with glaucoma was established for IL-6 and IL-17, with the relative risk values in the uncorrected model of 2.87 and 2.71, respectively (p < 0.001). However, in the adjusted model, the association of IL-6 with combined coronary heart disease with glaucoma increased to 2.92 (CI 2.80-3.27, p = 0.004), and IL-17 decreased to 2.64 (CI 2.51-2.85, p = 0.003). There was also a significant association of IL-4, IL-5, IL-12, IFNγ and TNFα with combined coronary heart disease with glaucoma. The study demonstrated new associations of systemic cytokines with the risk of developing combined coronary heart disease associated with glaucoma.

About the Authors

O. L. Fabrikantov
S. Fedorov National Medical Research Center “MNTK Eye Microsurgery”
Russian Federation

PhD, MD (Medicine), Professor, Director, S. Fedorov National Medical Research Center “MNTK Eye Microsurgery”.

Tambov


Competing Interests:

None



S. N. Shurygin
P. Lumumba Peoples’ Friendship University of Russia
Russian Federation

PhD, MD (Medicine), Head, Department of Gerontology, Physical and Rehabilitation Medicine, P. Lumumba Peoples’ Friendship University of Russia.

Moscow


Competing Interests:

None



T. E. Lipatova
V. Razumovsky Saratov State Medical University
Russian Federation

PhD, MD (Medicine), Associate Professor, Head, Department of Therapy with Сourses in Cardiology, Functional Diagnostics and Geriatrics, V. Razumovsky Saratov State Medical University.

Saratov


Competing Interests:

None



O. V. Sudakov
N. Burdenko Voronezh State Medical University
Russian Federation

PhD, MD (Medicine), Associate Professor, Professor of the Department of Management in Healthcare, N. Burdenko Voronezh State Medical University.

Voronezh


Competing Interests:

None



V. N. Potapov
Russian Medical Academy of Continuing Education
Russian Federation

PhD, MD (Medicine), Professor of the Department of Geriatrics and Medical and Social Expertise, Russian Medical Academy of Continuing Education.

Moscow


Competing Interests:

None



A. V. Chernov
N. Burdenko Voronezh State Medical University
Russian Federation

PhD, MD (Medicine), Associate Professor, Head, Department of Physical and Rehabilitation Medicine, Geriatrics IDPO, N. Burdenko Voronezh State Medical University.

Voronezh


Competing Interests:

None



G. V. Shavkuta
Rostov State Medical University
Russian Federation

PhD, MD (Medicine), Professor, Head of the Department of General Medical Practice (Family Medicine) (with Courses of Geriatrics and Physiotherapy), Rostov State Medical University.

Rostov-on-Don


Competing Interests:

None



A. V. Golikov
Kursk State Medical University
Russian Federation

PhD (Medicine), Associate Professor of the Department of Surgical Diseases No. 1, Kursk State Medical University.

Kursk


Competing Interests:

None



T. I. Yakunchenko
Belgorod State National Research University
Russian Federation

PhD, MD (Medicine), Professor, Head, Department of Propaedeutics of Internal Diseases and Clinical Information Technologies, Belgorod State National Research University.

Belgorod


Competing Interests:

None



V. V. Aksenov
Southwestern State University
Russian Federation

Vitaly V. Aksenov - Head, Laboratories of the Department of Biomedical Engineering Southwestern State University.

94 50 let Oktyabrya St Kursk 300540

Phone: +7 (910) 740-96-13


Competing Interests:

None



References

1. Egorov E.A., Erichev V.P. National guide to glaucoma. Moscow: GEOTAR-Media, 2019. 384 p.

2. Likhvantseva V.G., Sokolov V.A., Livanova O.N., Kovelenova I.V. Prediction of the probability of development and progression of primary open-angle glaucoma by regression modeling. Vestnik oftalmologii = Bulletin of Ophthalmology, 2018, Vol. 134, no. 3, pp. 35-41. (In Russ.)

3. Markelova E.V., Khokhlova A.S., Kirienko A.V., Filina N.V., Serebryanaya N.B. Features of immunopathogenesis and additional differential markers of primary open-angle and primary closed-angle glaucoma. Zdorovye i obrazovanie v XXI veke = Health and Education in the XXI Century, 2016, Vol. 18, no. 2, pp. 613-621. (In Russ.)

4. Slepova O.S., Arapiev M.U., Lovpache J.N., Balatskaya N.V., Kulikova I.G. Features of local and systemic cytokine status in healthy people of different ages and patients with the initial stage of primary open-angle glaucoma. Natsionalnyy zhurnal glaucoma = National Journal of Glaucoma, 2016, Vol. 15, no. 1, pp. 3-12. (In Russ.)

5. Fabrikantov O.L., Agarkov N.M., Lev I.V., Gurko T.S., Yablokov M.M., Moskaleva E.O., Moskalev A.A. Allostatic load as a method of objectification of age-related viability of patients with ophthalmopathology. Nauchnye rezultaty biomedicinskikh issledovaniy = Research Results in Biomedicine, 2021, Vol. 7, no. 3, pp. 451-460. (In Russ.)

6. Kharaeva Z.F., Khokonova T.M., Kambachokova Z.A., Barokova E.B., Noskova L.V. Serum cytokine values in patients with coronary heart disease and arterial hypertension. Klinicheskaya laboratornaya diagnostika = Russian Clinical Laboratory Diagnostics, 2018, Vol. 63, no. 10, pp. 626-629. (In Russ.)

7. Chukhraev A.M., Agarkov N.M., Konyaev D.A., Popova E.V., Yablokov M.M., Kulabukhov A.S. Informative value of lacrimal fluid interleukins in the diagnosis and development of angle-closure glaucoma in old age. Infektsiya i immunitet = Russian Journal of Infection and Immunity, 2020, Vol. 10, no. 4, pp. 755-761. (In Russ.) doi: 10.15789/2220-7619-IIT-1247.

8. Barcelos A.L., Oliveira E.A., Haute G.V., Costa B.P., Pedrazza L., Donadio M.V., Oliveira J.R., Bodanese L.C. Association of IL-10 to coronary disease severity in patients with metabolic syndrome. Clin. Chim. Acta, 2019, no. 495, pp. 394-398.

9. Clarke R., Valdes-Marquez E., Hill M., Gordon J., Farrali M., Hamsten A., Watkins H., Hopewell J.C. Plasma cytokines and risk of coronary heart disease in the PROCARDIS study. Open Heart, 2018, Vol. 5, no. 1, e000807. doi: 10.1136/openhrt-2018-000807.

10. Danesh J., Kaptoge S., Mann A.G., Sarwar N., Wood A., Angleman S.B., Wensley F., Higgins J.P., Lennon L., Eiriksdottir G., Rumley A., Whincup P.H., Lowe G.D., Gudnason V. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLoS Med., 2018, Vol. 5, no. 4, e78. doi: 10.1371/journal.pmed.0050078.

11. Farrali J.A., Filla M.S., Peters D.M. Role of fibronectin in primary open angle glaucoma. Cells, 2019, Vol. 8, no. 12, 1518. doi: 10.3390/cells8121518.

12. Hosseini K., Mortazavi S.H., Sadeghian S., Ayati A., Nalini M., Aminorroaya A., Tavolinejad H., Salarifar M., Pourhosseini H., Aein A., Jalali A., Bozorgi A., Mehrani M., Kamangar F. Prevalence and trends of coronary artery disease risk factors and their effect on age of diagnosis in patients with established coronary artery disease: Tehran Heart Center (2005-2015). BMC Cardiovasc. Disord., 2021, Vol. 21, no. 1, 477. doi: 10.1186/s12872-021-02293-y.

13. Laroche D., Nkrumah G., Ng C. Real-world efficacy of the Hydrus microstent in Black and Afro-Latinx patients with glaucoma: a retrospective study. Ther Adv Ophthalmol., no. 12, 2515841420964311. doi: 10.1177/2515841420964311.

14. Liu H., Jin F., Li Q., Gao Y., Liu X., Hou R. IL-34 and coronary heart disease complicated with diabetes mellitus. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021, Vol. 46, no. 12, pp. 1409-1414.

15. Mars N., Lindbohm J.V., Parolo P.D., Widen E., Kaprio J., Palotie A., Ripatti F.S. Systematic comparison of family history and polygenic risk across 24 common diseases. Am. J. Hum. Genet., 2022, Vol. 109, no. 12, pp. 2152-2162. doi: 10.1016/j.ajhg.2022.10.009.

16. Ridker P.M., Rane M. Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease. Circ. Res., 2021, Vol. 128, no. 11, pp. 1728-1746.

17. Tanase D.M., Gosav E.M., Radu S., Ouatu A., Rezus C., Ciocoiu M., Costea C.F., Floria M. Arterial hypertension and interleukins: potential therapeutic target or future diagnostic marker? Int. J. Hypertens., 2019, no. 2019, 3159283. doi: 10.1155/2019/3159283.

18. Wang Y., Zhou C., Yu T., Zhao F. Correlation between Changes in Serum RBP4, hs-CRP, and IL-27 levels and rosuvastatin in the treatment of coronary heart disease. J. Healthc. Eng., 2021, no. 2021, 8476592. doi: 10.1155/2021/8476592.

19. Xu Y., Ye J., Wang M., Liu J., Wang Z., Jiang H., Ye D., Zhang J., Wan J. The expression of interleukin-25 increases in human coronary artery disease and is associated with the severity of coronary stenosis. Anatol. J. Cardiol., 2020, Vol. 23, no. 3, pp. 151-159.

20. Yuan S., Lin A., He Q.Q., Burgess S., Larsson S.C. Circulating interleukins in relation to coronary artery disease, atrial fibrillation and ischemic stroke and its subtypes: A two-sample Mendelian randomization study. Int. J. Cardiol., 2020, no. 319, pp. 99-104.


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Fabrikantov O.L., Shurygin S.N., Lipatova T.E., Sudakov O.V., Potapov V.N., Chernov A.V., Shavkuta G.V., Golikov A.V., Yakunchenko T.I., Aksenov V.V. Cytokine profile in the patients with combined cardio- and ophtalmopathies. Medical Immunology (Russia). 2024;26(2):313-320. (In Russ.) https://doi.org/10.15789/1563-0625-CPO-2639

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ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)