IMMUNE SYSTEM RE-INTEGRATION INDUCED BY HYPNOSUGGESTION IN ONCOLOGICAL PATIENTS
https://doi.org/10.15789/1563-0625-2008-6-527-534
Abstract
Abstract. The 18 patients with stomach cancer were investigated. This group was divided in to two groups 9 people in each: one with psychotherapeutic treatment 3 men and 6 women aged from 51 to 68 years (with III stage 8 patients and with I stage 1 patient); another one with surgical treatment (control subgroup) consists of 5 men and 4 women aged from 51 to 71 years (III stage).
A special method of hypnosuggestive therapy (HST) devised for this situation to modify psychosomatic disorders was used. A level of CD34+ was measured before HST and after 1 month and telomere length as well as apoptosis were measured in lymphocytes before HST and after 3, 5, 7, 9 and 11 weeks. In control group a telomere length in lymphocytes was measured. In both subgroups of patients with cancer a telomere lengths were 500 b.p. shorter than in donors before treatment. Consequently HST after 7 weeks treatment significant telomere length elongation on 1000 b.p. and apoptosis increase to 1,7% were found. Hereby these results have shown that hypnosuggestive therapy reintegrats immune system in cancer patients which discover new key points for psycho immunological investigations. (Med. Immunol., vol. 10, N 6, pp 527-534).
About the Authors
O. V. Bukhtoyarov
ГУ НИИ клинической иммунологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
D. M. Samarin
ГУ НИИ клинической иммунологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. I. Borisov
ГУ НИИ клинической иммунологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. V. Senyukov
ГУ НИИ клинической иммунологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. S. Kozhevnikov
ГУ НИИ клинической иммунологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. A. Kozlov
ГУ НИИ клинической иммунологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
References
1. Абрамов В.В., Абрамова Т.Я., Егоров Д.Н. Высшая нервная деятельность и иммунитет. – Новосибирск: СО РАМН, 2001. – 123 с.
2. Антонов В.Г., Козлов В.К. Патогенез онкологических заболеваний: иммунные и биохимические феномены и механизмы. Внеклеточные и клеточные механизмы общей иммунодепрессии и иммунной резистентности // Цитокины и воспаление. – 2004. – Т. 3, № 1. – С. 8-19.
3. Архангельский А.Е. Психопатология беременности, родов и послеродового периода. – СПб., 2007. – 80 с.
4. Борисов В.И. Укорочение длины теломерных районов ДНК при иммунодефицитных, аллергических и аутоиммунных состояниях: Дис. … канд. биол. наук: спец. – Новосибирск, 2007. – 125 с.
5. Корнева Е.А. Введение в иммунофизиологию. – СПб.: ЭЛБИ, 2003. – 48 с.
6. Бухтояров О.В., Кожевников В.С., Шишков А.А., Селедцов В.И., Козлов В.А. Психологическая и иммунная защита онкологических больных – две составляющие одной проблемы // Вопр. онкологии. – 2005. – Т. 51, № 6. – С. 703-707.
7. Ader R., Felten D.L., Cohen N. Psychoneuroimmunology. – San Diego: Academic Press, 2001. – 1583 p.
8. Atesci F.C., Baltalarli B., Oguzhanoglu N.K. Psychiatric morbidity among cancer patients and awareness of illnes // Supp. Care Cancer. – 2004. – Vol. 12, N 3. – Р. 161-167.
9. Barak Y. The immune system and happiness // Autoimmun. Rev. – 2006. – Vol. 5, N 8. – Р. 523 - 527.
10. Besedovsky H.O.. A.D. Rey Physiology of psychoneuroimmunology: a personal view // Brain Behav. Immun. – 2007. – Vol. 21, N 1. – Р. 34-44.
11. Caspi A., Sugden K., Moffitt T.E Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene // Science. – 2003. – Vol. 301, № 5631. – Р. 386-389.
12. Conti A. Oncology in neuroimmunomodulation: what progress has been made? // Ann. NY Acad. Sci. – 2000. – Vol. 917. – Р. 68-83.
13. Cottler-Fox M.H., Lapidot T., Petit I. Stem сell mobilization // Hematology. – 2003. – Р. 419-437.
14. Forlenza M.J., Latimer J.J., Baum A. The effects of stress on DNA repair // Psychol. Health: An Int. J. – 2000. – Vol. 15. – P. 881-981.
15. Gidron Y., Russ K., Tissarchondou H. The relation between psychological factors and DNA - damage: a critical review // Biol. Psychol. – 2006. – Vol. 72, N 3. – Р. 291-304.
16. Gruzelier J.H. A review of the impact of hypnosis, relaxation, guided imagery and individual differences on aspects of immunity and health // Stress. – 2002. – Vol. 5, N 2. – P. 147-163.
17. Hall N.R., McGillis J.P., Spangelo B.L. Evidence that thymosins and other biological response modifiers can function as neuroactive immunotransmitters // J. Immunol. – 1985. – N 135. – Р. 806-811.
18. Halliwell B. Oxidative stress and cancer: have we moved forward? // Biochem. J. – 2007. – Vol. 401, N 1. – Р. 1-11.
19. Hidderley M., Holt M. A pilot randomized trial assessing the effects of autogenic training in early stage cancer patients in relation to psychological status and immune system responses // Eur. J. Oncol. Nurs. – 2004. – Vol. 8, N 1. – P. 61-65.
20. Hudacek K.D. A review of the effects of hypnosis on the immune system in breast cancer patients: a brief communication // Int. J. Clin. Exp. Hypn. – 2007. – Vol. 55, N 4. – Р. 411-425.
21. Keller M., Sommerfeldt S., Fischer C., Knight L., Riesbeck M., Löwe B., Herfarth C., Lehnert T. Recognition of distress and psychiatric morbidity in cancer patients: a multi-method approach // Ann. Onc. – 2004. – Vol. 15, N 8. – Р. 1243-1249.
22. Kiecolt-Glaser J.K., MaruchaPh.T., Atkinson C. Hypnosis as a modulator of cellular immune dysregulation during acute stress // J. Consul. Clin. Psychol. – 2001. – Vol. 69, N 4. – P. 674-682.
23. Kiecolt-Glaser J.K., Robles T.F., Heffner K.L. Psycho-oncology and cancer: psychoneuroimmunology and cancer // Ann. Oncol. – 2002. – Vol. 13, N 4. – Р. 165-169.
24. Lawsin C., DuHamel K., Itzkowitz S.H. Demographic, medical, and psychosocial correlates to CAM use among survivors of colorectal cancer // Support Care Cancer. – 2007. – Vol. 15, N 5. – Р. 557-564.
25. Lewis C., O’Brien R., Barraclough J. The psychoimmunology of сancer. – N.Y.: Oxford Univ. Press, 2002. – 272 p.
26. Lutgendorf S.K., Sood A.K. , Anderson B. Social support, psychological distress, and natural killer cell activity in ovarian cancer // J. Clin. Oncol. – 2005. – Vol. 23, N 28. – Р. 7105-7113.
27. McGuire T.R., Kessinger A., Hock L. Elevated transforming growth factor beta levels in the plasma of cytokine-treated cancer patients and normal allogeneic stem cell donors // Cytotherapy. – 2001. – Vol. 3, N 5. – Р. 361-364.
28. Miller G.E., Cohen S. Psychological interventions and the immune system: a meta-analytic review and critique // Health Psychol. – 2001. – Vol. 20, N 1. – P. 47-63.
29. Montes C.L., Chapoval A.I., Nelson J. Tumor-induced senescent T cells with suppressor function: a potential form of tumor immune evasion // Cancer Res. – 2008. – Vol. 68. – P. 870-879.
30. Monti D.A., Sufian M., Peterson C. Potential role of mind-body therapies in cancer survivorship // Cancer. – 2008. – Vol. 112, N 11. – Р. 2607-2616.
31. Norman S.B., Means-Christensen A.J., Craske M.G. Associations between psychological trauma and physical illness in primary care // J. Trauma Stress. – 2006. – Vol. 19, N 4. – Р. 461 - 470.
32. Ott M.J., Norris R.L., Bauer-Wu S.M. Mindfulness meditation for oncology patients: a discussion and critical review integrative cancer therapies // Integr. Cancer. Ther. – 2006. – Vol. 5, N 2. – Р. 98-108.
33. Ouyang Q., Baerlocher G., Vulto I. Telomere length in human natural killer cell subsets // Hematopoietic Stem Cells. – 2007. – Vol. 1106. – Р. 240-252.
34. Reiche E.M., Morimoto H.K., Nunes S.M. Stress and depression-induced immune dysfunction: implications for the development and progression of cancer // Int. Rev. Psychiatry. – 2005. – Vol. 17, N 6. – Р. 515-527.
35. Rusé-Riol F., Legros M., Bernard D. Variations in committed stem cells (CFU-GM and CFU-TL) in the peripheral blood of cancer patients treated by sequential combination chemotherapy for breast cancer // Cancer Res. – 1984. – Vol. 44. – Р. 2219-2224.
36. Segerstrom S.C., Miller G.E. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry // Psychol. Bull. – 2004. – Vol. 130, N 4. – Р. 601-630.
37. Son N.H., Murray Sh., Yanovski J. Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age // J. Immunol. – 2000. – Vol. 165. – Р. 1191 - 1196.
38. Thaker P.H., Han L.Y., Kamat A.A. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma // Nat. Med. – 2006. – Vol. 12. – P. 939-944.
39. Thompson H.J. Oxidative DNA damage and cancer risk assessment // J. Nutr. – 2006. – Vol. 136, N 10. – Р. 2693S-2694S.
40. Vedhara K., Irwin М. Human psychoneuroimmunology. – N.Y.: Oxford Univ. Press, 2005. – 368 р.
41. Walker L.G. The psychoimmunology of cancer // Cancer Topics. – 2000. – N 11. – Р. 17-19.
42. Walker L.G., Ratcliffe M.A., Dawson A.A. Relaxation and hypnotherapy: long term effects on the survival of patients with lymphoma // Psycho-Oncology. – 2000. – Vol. 9. – Р. 355-356.
43. Wood G.J., Bughi S., Morrison J. Hypnosis, differential expression of cytokines by T-cell subsets, and the hypothalamo-pituitary-adrenal axis // Am. J. Clin. Hypn. – 2003. – Vol. 45, N 3. – P. 179 - 196.
44. Yan B., Wang H., Rabbani Z.N. Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation // Cancer Res. – 2006. – Vol. 66, N 24. – Р. 11565-11570.
45. Zhou J., Shen X., Huang J. Telomere length of transferred lymphocytes correlates with In vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy // J. Immunol. – 2005. – Vol. 175. – Р. 7046-7052.
Review
For citations:
Bukhtoyarov O.V., Samarin D.M., Borisov V.I., Senyukov V.V., Kozhevnikov V.S., Kozlov V.A. IMMUNE SYSTEM RE-INTEGRATION INDUCED BY HYPNOSUGGESTION IN ONCOLOGICAL PATIENTS. Medical Immunology (Russia). 2008;10(6):527-534. (In Russ.) https://doi.org/10.15789/1563-0625-2008-6-527-534
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