HLA DRB1* ASSOCIATION WITH REPRODUCTIVE DISORDERS IN WOMEN
https://doi.org/10.15789/1563-0625-2007-6-643-648
Abstract
Abstract. HLA DRB1* gene associations with idiopathic fetal losses and infertility were studied in women. It was shown that idiopathic fetal losses are associated with HLA DRB1*04 specificity, whereas infertility correlated with HLA DRB1*04/07 genotype. The associations revealed may indicate to a special role of autoimmune events in women during pregnancy. The authors suggest a hypothesis on existence of several immune modes of reproductive losses. HLA genotyping may be applied as a basic technique for their determination.
About the Authors
L. A. Gordeeva
Институт экологии человека СО РАН, г. Кемерово
Russian Federation
Russian Federation
A. V. Shabaldin
Институт экологии человека СО РАН, г. Кемерово
Russian Federation
Russian Federation
A. N. Glushkov
Институт экологии человека СО РАН, г. Кемерово
Russian Federation
Russian Federation
O. A. Glushkova
Институт экологии человека СО РАН, г. Кемерово
Russian Federation
Russian Federation
O. S. Makarchenko
Институт экологии человека СО РАН, г. Кемерово
Russian Federation
Russian Federation
T. A. Simonova
Кемеровский областной перинатальный центр
Russian Federation
Russian Federation
I. V. Vetrova
Институт экологии человека СО РАН, г. Кемерово
Russian Federation
Russian Federation
E. A. Sherina
Институт экологии человека СО РАН, г. Кемерово
Russian Federation
Russian Federation
N. K. Zhilinskaya
Кемеровский областной перинатальный центр
Russian Federation
Russian Federation
V. I. Minina
Институт экологии человека СО РАН, г. Кемерово
Russian Federation
Russian Federation
References
1. Болдырева М.Н., Хаитов Р.М., Барцева О.Б., Гузов И.И., Барков И.Ю., Померанцева Е.И., Богатова О.В., Гуськова И.А., Янкевич Т.Э., Хромова Н.А., Сергеев И.В., Филиппова Е.В., Алексеев Л.П. Исследование роли HLA-DRB1-генов при невынашивании беременности неясного генеза // Иммунология. – 2004. – № 1. – С. 4-8.
2. Говалло В.И. Иммунология репродукции. – М.: Медицина, 1987. – 304 с.
3. Гордеева Л.А., Шабалдин А.В., Глушков А.Н., Казакова Л.М., Симонова Т.А., Жилинская Н.К., Филипенко М.Л. Иммуногенетические методы в прогнозировании иммунопатологии раннего онтогенеза (методические рекомендации) // Медицина в Кузбассе. – 2004. – № 3. – 28 с.
4. Исхаков А.Т., Асатова М.М., Расулова М.И. HLA-профили при невынашивании беременности // Иммунология. – 1996. – № 1. – С. 27-28.
5. Моджил Р.Д. Иммуногенетика взаимодействий «мать-плод». Иммуногенетика человека. – М.: Мир, 1994. – Т. 1. – С. 81-103.
6. Певницкий Л.А. Статистическая оценка ассоциаций HLA-антигенов с заболеваниями // Вестник АМН СССР. – 1988. – № 7. – С. 48-51.
7. Реброва, О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICА / О.Ю. Реброва. – М.: «Медиа Сфера», 2002. – 304 с.
8. Шабалдин А.В., Глушков А.Н., Логинова Л.А. Генетические основы иммунопатологии раннего онтогенеза // Вестник РАЕН Западно-Сибирского отделения. – 2001. – № 4. – С. 37-44.
9. Шабалдин А.В., Глушков А.Н., Симонова Т.А., Логинова Л.А., Штейн М.А. Влияние иммунных взаимодействий в системе мать-плод на развитие беременности // Мать и Дитя в Кузбассе. – 2001. – № 2(3). – С. 21-22.
10. Camps M.T., Cuadrado M.J., Ocon P., Alonso A., Gutierrez A., Guil M., Grana M.I., de Ramon E. Association between HLA class II antigens and primary antiphospholipid syndrome from the south of Spain // Lupus. – 1995. – Vol. 4. – P. 51-55.
11. Carreiras M., Montagnani S., Layrisse Z. Preeclampsia: a multifactorial disease resulting from the interaction of the feto-maternal HLA genotype and HCMV infection // Am. J. Reprod. Immunol. – 2002. – Vol. 48. – P. 176-183.
12. Choudhury S.R., Knapp L.A. Human reproductive failure II: immunogenetic and interacting factors // Hum. Reprod. Update. – 2001. – Vol. 7, N 2. – P. 135-160.
13. Christiansen O.B., Ulkova-Gallova Z., Mohapeloa H., Krauz V. Studies on associations between human leukocyte antigen (HLA) class II alleles and antiphospholipid antibodies in Danish and Czech women with recurrent miscarriages // Hum. Reprod. – 1998. – Vol. 13, N 12. – P. 3326-3331.
14. Donner H., Seidl C., van der Auwera B., Braun J., Siegmund T., Herwig J., Weets I., Usadel K.H., Badenhoop K. HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry // Tissue Antigens. – 2000. – Vol. 55, N 3. – P. 271-274.
15. Dorac M.T., Mills K.I., Gaffney D., Wilson D.W., Galbraith I., Henderson N., Burnett A.K. Homozygous MHC genotypes and longevity // Hum. Hered. – 1994. – Vol. 44, N 5. – P. 271-278.
16. Goldstein R., Moulds J.M., Smith C.D., Sengar D.P. MHC studies of the primary antiphospholipid antibody syndrome and of antiphospholipid antibodies in systemic lupus erythematosus // J. Rheumatol. – 1996. – Vol. 23. – P. 1173-1179.
17. Hataya I., Takakuwa K., Tanaka K. Human leukocyte antigen class II genotype in patients with recurrent fetal miscarriage who are positive for anticardiolipin antibody. // Fertil. Steril. – 1998. – Vol. 70, N 5. – P. 919-923.
18. Kilpatrick D.C., Liston W.A. Influence of histocompatibility antigens in recurrent spontaneous abortion and its relevance to leukocyte immunotherapy. // Hum. Reprod. – 1993. – Vol. 8, N 10. – P. 1645-9.
19. Kruse C., Steffensen R., Varming K., Christiansen O.B. A study of HLA-DR and –DQ alleles in 588 patients and 562 controls confirms that HLA-DRB1*03 is associated with recurrent miscarriage // Hum. Reprod. – 2004. – Vol. 19, N 5. – P. 1215-1221.
20. Kurpisz M, Fernandes N. MHC and reproduction // Polish J. of Immunol. – 1993. – Vol. 13, N 1. – P. 81-93.
21. Laitinen, T. A set of MHC haplotypes found among Finnich couples suffering from recurrent spontaneous abortions //Am J Reprod Immunol. – 1993. – Vol. 29. – P. 148-154.
22. Moreau F., Lefebvre S., Gourdand L. Specific binding of nuclear factors to the HLA-G gene promoter correlated with a lack of HLA-G transcripts in first trimester human fetal liver // Hum Immunol. – 1998. – Vol. 59. – P. 751-757.
23. Ober C. Studies of HLA, fertility and mate choice in a human isolate // Hum. Reproduct. Update. – 1999. – Vol. 5, N 2. – P. 103-107.
24. Ober C., Weitkamp L.R., Cox N., Dytch H., Kostyu D., Elias S. HLA and mate choice in Humans // Am. J. Hum. Genet. – 1997. – Vol. 61. – P. 497-504.
25. Peterson R.D.A., Tuck-Muller C.M., Spinnato J.A. An HLA – haplotype associated with preeclampsia and intrauterine growth retardation // Am. J. Reprod. Immunol. – 1994. – Vol. 31. – P. 177-179.
26. Pociot F., Braint L., Jongeneel C.V., Molvig J., Worsaae H., Abbal M., Thonsen M., Nerup J., Cambon-Thomsen A. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNFalpha and TNFbeta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus // Eur. J. Immunol. – 1993. – Vol. 23. – P. 224-231.
27. Poland G.A., Jacobson R.M. The genetic basis for variation in antibody response to vaccines // Current Option in Pediatrics. – 1998. – Vol. 10. – P. 208-215.
28. Radhupathy R. Maternal anti-placental cellmediated reactivity and spontaneous abortions // Am. J. Reprod. Immunol. – 1997. – Vol. 37. – P. 478-484.
29. Sambrook, J. Molecular cloning: a laboratory manual, 2nd ed./ Sambrook J, Fritsch E., Maniatis T. // Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1989.
30. Sasaki T., Yamada H., Kato E.H., Sudo S., Kishida T., Nishigaki F., Fujimoto S. Increased frequency of HLA DR4 allele in women with unexplained recurrent spontaneous abortions, detected by the method of RCR-SSP. // J. Reprod. Immunol. – 1997. – Vol. 32. – P. 273-279.
31. Szekeres-Bartho J. Immunological relationship between the mother and the fetus // Int. Rev. Immunol. – 2002. – Vol. 21, N 6. – P. 471-495.
32. Vojvodic S., Belic B. The HLA antigen system in married couples with recurrent spontaneous abortions // Med. Pregl. – 2001. – Vol. 54, N 1-2. – P. 75-79.
33. Weitkamp L.R. Ancestral and recombinant 16-locus HLA-gaplotypes in the Hutterites // Immunogenetics. – 1999. – Vol. 49. – P. 491-497.
34. Wilson A.G., de Vries N., Pociot F. An allelic polymorphism within the human tumour necrosis factor promoter region is strongly associated with HLA A1, B8 and DR3 alleles. // J. Exp. Med. – 1993. – Vol. 177. – P. 557-560.
Review
For citations:
Gordeeva L.A., Shabaldin A.V., Glushkov A.N., Glushkova O.A., Makarchenko O.S., Simonova T.A., Vetrova I.V., Sherina E.A., Zhilinskaya N.K., Minina V.I. HLA DRB1* ASSOCIATION WITH REPRODUCTIVE DISORDERS IN WOMEN. Medical Immunology (Russia). 2007;9(6):643-648. (In Russ.) https://doi.org/10.15789/1563-0625-2007-6-643-648
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