INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL
https://doi.org/10.15789/1563-0625-2008-6-507-512
Abstract
Abstract. Mediators of inflammation may play a sufficient role in destabilization of atherosclerotic plaque, disturbing the balance between collagen formation and its degradation in fibrotic capsule. Using a transgenic murine model, the effects of induced inflammation upon expression of factors determining posttranslational modification and degradation of collagen, i.e., prolyl-4-hydroxylase, matrix metalloproteinases-2, -9 (MMP-2, -9), and tissue inhibitor of metalloproteinases (TIMP-1) were evaluated. It has been shown that, under significant increase of interferon-γ and interleukin-1β, the synthesis of prolyl-4-hydroxylase and MMP - 9 is decreased, whereas expression of collagen, MMP-2 and TIMP-1 genes was not changed. (Med. Immunol., vol. 10, N 6, pp 507-512).
About the Authors
E. V. Shlyakhto
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-Петербург
Russian Federation
Russian Federation
N. A. Gavrisheva
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-Петербург
Russian Federation
Russian Federation
O. A. Ovchinnikova
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, Санкт-Петербург
Russian Federation
Russian Federation
G. K. Hansson
Каролинский институт, Стокгольм
Sweden
Sweden
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Review
For citations:
Shlyakhto E.V., Gavrisheva N.A., Ovchinnikova O.A., Hansson G.K. INFLUENCE OF INDUCED INFLAMMATION UPON COLLAGEN METABOLISM OF UNSTABLE ATHEROSCLEROTIC PLAQUE IN MURINE MODEL. Medical Immunology (Russia). 2008;10(6):507-512. (In Russ.) https://doi.org/10.15789/1563-0625-2008-6-507-512
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